E-ISSN 2146-8389
 

Original Research (Original Article) 


Increased level of Urinary 8-oxo-Gsn in Patients with Heart Failure

Ke Chai, Tong Liu, Weimeng Tian, Wanrong Zhu, Jiefu Yang, Jianping Cai, Hua Wang.

Abstract
Background
The level of RNA oxidation in patients with heart failure (HF) and its effect have not been well established. The aim of our study was to investigate the relationship between urinary 8-oxo-7, 8-dihydroguanosine (8-oxo-Gsn), a marker for oxidative stress to RNA and HF.
Methods
A total of 191 heart failure patients from March 2014 to March 2018 and 155 healthy controls were included in this study and their morning urine was collected. The level of urinary 8-oxo-Gsn was measured by ultra high-performance liquid chromatography mass spectrometry/ mass spectrometry (UPLC-MS/MS) and adjusted by urinary creatinine. Heart failure with reduced ejection fraction (HFrEF) was defined as left ventricular ejection fraction (LVEF) <40%. Heart failure with preserved ejection fraction (HFpEF) was defined as LVEF 50% with diastolic dysfunction.
Results
8-oxo-Gsn in heart failure patients was significantly increased compared with age- and sex-matched healthy control subjects [4.20(3.09-5.77) versus 2.75(2.59-2.85), p<0.001]. The level of 8-oxo-Gsn was positively correlated with age (r=0.257, p=0.001) and N-terminal pro-BNP (NT-pro-BNP, r=0.257, p<0.001), and negatively correlated with diastolic blood pressure (r=-0.147, p=0.049), hemoglobin (r=-0.181, p=0.013) and creatinine clearance rate (r= -0.215, p=0.004). Patients with HFrEF and HFpEF exhibited both higher levels of 8-oxo-Gsn than control subjects (all p<0.001), while there was no difference between HFrEF and HFpEF [4.44(3.12-7.12) versus 4.02(3.10-5.67), p=0.406].
Conclusions
The level of urinary 8-oxo-Gsn is increased in patients with HF, indicating that HF may be associated with increased oxidative damage to RNA and urinary 8-oxo-Gsn be useful in the diagnosis and evaluation of HF.

Key words: Urinary 8-oxo-Gsn; Heart failure; RNA oxidation


 
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How to Cite this Article
Pubmed Style

KC, Liu T, Tian W, Zhu W, Yang J, Cai J, Wang H. Increased level of Urinary 8-oxo-Gsn in Patients with Heart Failure. Oxid Antioxid Med Sci. 2020; 9(1): 1-7. doi:10.5455/oams.20200105102508


Web Style

KC, Liu T, Tian W, Zhu W, Yang J, Cai J, Wang H. Increased level of Urinary 8-oxo-Gsn in Patients with Heart Failure. http://www.ejmoams.com/?mno=80667 [Access: May 07, 2020]. doi:10.5455/oams.20200105102508


AMA (American Medical Association) Style

KC, Liu T, Tian W, Zhu W, Yang J, Cai J, Wang H. Increased level of Urinary 8-oxo-Gsn in Patients with Heart Failure. Oxid Antioxid Med Sci. 2020; 9(1): 1-7. doi:10.5455/oams.20200105102508



Vancouver/ICMJE Style

KC, Liu T, Tian W, Zhu W, Yang J, Cai J, Wang H. Increased level of Urinary 8-oxo-Gsn in Patients with Heart Failure. Oxid Antioxid Med Sci. (2020), [cited May 07, 2020]; 9(1): 1-7. doi:10.5455/oams.20200105102508



Harvard Style

, K. C., Liu, . T., Tian, . W., Zhu, . W., Yang, . J., Cai, . J. & Wang, . H. (2020) Increased level of Urinary 8-oxo-Gsn in Patients with Heart Failure. Oxid Antioxid Med Sci, 9 (1), 1-7. doi:10.5455/oams.20200105102508



Turabian Style

, Ke Chai, Tong Liu, Weimeng Tian, Wanrong Zhu, Jiefu Yang, Jianping Cai, and Hua Wang. 2020. Increased level of Urinary 8-oxo-Gsn in Patients with Heart Failure. Oxidants and Antioxidants in Medical Science, 9 (1), 1-7. doi:10.5455/oams.20200105102508



Chicago Style

, Ke Chai, Tong Liu, Weimeng Tian, Wanrong Zhu, Jiefu Yang, Jianping Cai, and Hua Wang. "Increased level of Urinary 8-oxo-Gsn in Patients with Heart Failure." Oxidants and Antioxidants in Medical Science 9 (2020), 1-7. doi:10.5455/oams.20200105102508



MLA (The Modern Language Association) Style

, Ke Chai, Tong Liu, Weimeng Tian, Wanrong Zhu, Jiefu Yang, Jianping Cai, and Hua Wang. "Increased level of Urinary 8-oxo-Gsn in Patients with Heart Failure." Oxidants and Antioxidants in Medical Science 9.1 (2020), 1-7. Print. doi:10.5455/oams.20200105102508



APA (American Psychological Association) Style

, K. C., Liu, . T., Tian, . W., Zhu, . W., Yang, . J., Cai, . J. & Wang, . H. (2020) Increased level of Urinary 8-oxo-Gsn in Patients with Heart Failure. Oxidants and Antioxidants in Medical Science, 9 (1), 1-7. doi:10.5455/oams.20200105102508





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