Free Radicals: Functions, Types and its Source

Perspective - Oxidants and Antioxidants in Medical Science (2022)

Free Radicals: Functions, Types and its Source

Kunming Liu*
Department of Chemistry, Jiangxi University of Science and Technology, China
*Corresponding Author:
Kunming Liu, Department of Chemistry, Jiangxi University of Science and Technology, Ganzhou, China, Email: [email protected]

Received: 02-Feb-2022, Manuscript No. EJMOAMS-22-53734; Editor assigned: 04-Feb-2022, Pre QC No. EJMOAMS-22-53734 (PQ); Reviewed: 18-Feb-2022, QC No. EJMOAMS-22-53734; Revised: 23-Feb-2022, Manuscript No. EJMOAMS-22-53734 (R); Published: 02-Mar-2022


Free radicals are highly reactive and unstable molecules that are produced in the body naturally as a derivative of metabolism (oxidation), or by exposure to toxins in the environment such as tobacco smoke and ultraviolet light. Free radicals have a lifespan of only a fraction of a second, but during that time can damage DNA, sometimes resulting in the mutations that can lead to cancer. Antioxidants in the foods we eat can neutralize the unstable molecules, reducing the risk of damage.

Free radicals are associated with human disease, including cancer, atherosclerosis, Alzheimer’s disease, Parkinson’s disease and plenty of others. They also may have a link to aging, which has been defined as a gradual accumulation of free-radical damage.

Substances that generate free radicals can be found in the food we eat, the medicines we take, the air we breathe and the water we drink. These substances include fried foods, alcohol, tobacco smoke, pesticides and air pollutants.

When there are more free radicals present than can be kept in balance by antioxidants, the free radicals can begin doing harm to fatty tissue, DNA, and proteins in your body. Proteins, lipids, and DNA make up a large part of your body, so that damage can lead to a vast number of diseases over time. These include:

• Diabetes

• Atherosclerosis, or the hardening of the blood vessels

• Inflammatory conditions

• High blood pressure, which is also known as hypertension

• Heart disease

• Neurodegenerative diseases, such as Parkinson’s and Alzheimer’s

• Cancer

Functions of free radicals

Free radicals are constantly formed in your body. Without antioxidants, free radicals would cause serious harm very quickly, eventually resulting in death. However free radicals additionally serve essential features which might be important for health. For example, your immune cells use free radicals to fight infections.

As a result, your body needs to maintain a certain balance of free radicals and antioxidants. Several lifestyle, stress and environmental factors are known to promote excessie free radical formation including:

• Air pollutants

• Cigarette smoking

• Alcohol consumption

• Toxins

• High blood sugar levels

• High consumption of polyunsaturated fatty acids

• Radiation including excessive sunbathing

• Bacterial, viral or fungal infections

• Excessive consumption of iron, magnesium, copper or zinc

• Too much or too little oxygen in your body.

• Intense and prolonged exercise, which causes tissue damage

• Excessive consumption of antioxidants consisting of nutrition C and E

• Antioxidant deficiency

Types of free radicals

There are many types of free radicals, though, in humans, the most significant are oxygen free radicals (reactive oxygen species). Examples include singlet oxygen (when oxygen is “split” into single atoms with unpaired electrons), hydrogen peroxide, superoxide, and hydroxyl anions.

Causes/sources of free radicals

Free radicals can be produced in a few different ways. They may be generated from normal metabolic processes in the body, or by exposure to carcinogens (cancer causing substances) in the environment.

Free radicals due to normal metabolic processes:

Our body often produces free radicals in the process of breaking down nutrients to create the energy which allows our bodies to function. The production of free radicals in normal metabolic processes such as this is one of the reasons that the risk of cancer increases with age, even when people have few exposures to cancer-causing substances.

Free radicals due to exposure to carcinogens: Exposure to carcinogens in our environment can also produce free radicals. Examples of some carcinogens include:

• Tobacco smoke

• Ultraviolet radiation

• Radon in the home

• Environmental and occupational substances and chemicals such as asbestos and vinyl chloride

• Some viruses

• Medical radiation

• Air pollution

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