ISSN 2146-8389
 

Original Research (Original Article) 


Cadmium exposure-induced oxidative stress; delay in sexual maturation and impaired hormones in developing rat ovary

Dailiah P. Roopha, Padma C. Latha.

Cited by (4)

Abstract
Cadmium (Cd) is a common environmental pollutant by discharge from industrial processes. Cd one of the elements found to damage antioxidant systems in mammals. The major route of Cd exposure for the general population is oral intake. However, excess Cd exposure is associated with various pathological conditions including reproductive dysfunction. Cd can traverse the placental barrier and cause wide range of abnormalities in fetal development. Therefore, the present study was carried out to determine the toxic effects of lactational Cd exposure on ovary in developing female Wistar rats. Two different doses of cadmium (50 and 200 ppm) were given to Wistar rats aged 45 and 65 days. Specific activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) were estimated. Hydrogen peroxide (H2O2), lipid peroxidation (LPO) and serum gonadotropins viz luteinizing hormone (LH) and follicle stimulating hormone (FSH) were also assayed. Specific activities of SOD, CAT, GPx, GR and GST were decreased while H2O2 and LPO increased. These results suggest that lactational Cd exposure induces oxidative stress in rat ovary by decreasing antioxidant enzymes, which were associated with delayed puberty and altered steroids and gonadotropin levels.

Key words: Cadmium; Ovary; Sexual maturation


 
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REFERENCES
1.Elekofehinti OO, Omotuyi IO, Olaremu AG, Abayomi TG. Heavy metals distribution and lipid profile in the stomach of cow grazed in Akungba-Akoko, Ondo State, Nigeria. Afr J Biochem Res 2012; 6:146-9.


2.Morrow H. Cadmium and cadmium alloys. Kirk-Othmer Encyclopedia of Chemical Technology, 2001.

http://dx.doi.org/10.1002/0471238961.0301041303011818.a01.pub2


3.U.S. Geological Survey, Mineral Commodity Summaries, Reston, VA, USA, January 2013.


4.Herron N. Cadmium compounds. Kirk-Othmer Encyclopedia of Chemical Technology, 2003.

http://dx.doi.org/10.1002/0471238961.0301041308051818.a01.pub2


5.Hendy GA, Baker AJ, Evart CF. Cadmium tolerance and toxicity, oxygen radical processes and molecular damage in cadmium tolerant and cadmium-sensitive clones of Holcus lanata. Acta Bot Neerl 1992; 41:271-81.


6.Balakhnina T, Kosobryukhov A, Ivanov A, Kreslavskii V. The effect of cadmium on CO2 exchange, variable fluorescence of chlorophyll and the level of antioxidant enzymes in pea leaves. Rus J Plant Physiol 2005; 52:15-20.

http://dx.doi.org/10.1007/s11183-005-0003-z


7.Darbre PD. Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast. J Appl Toxicol 2006; 26:191-7.

http://dx.doi.org/10.1002/jat.1135

[
Pubmed]   


8.Agarwal A, Gupta S, Sikka S. The role of free radicals and antioxidants in reproduction. Curr Opin Obstet Gynecol 2006; 18:325-32.

http://dx.doi.org/10.1097/01.gco.0000193003.58158.4e

[
Pubmed]   


9.Piasek M, Schonwald N, Blanusa M, Kostial K, Laskey JW. Biomarkers of heavy metal reproductive effects and interaction with essential elements in experimental studies on female rats. Arh Hig Rada Toxicol 1996; 47:245-59.

[
Pubmed]   


10.Thompson J, Bannigan J. Cadmium: toxic effects on the reproductive system and the embryo. Reprod Toxicol 2008; 25:304-15.

http://dx.doi.org/10.1016/j.reprotox.2008.02.001

[
Pubmed]   


11.Henson MC, Chedrese PJ. Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp Biol Med (Maywood) 2004; 229:383-92.

[
Pubmed]   


12.Anane R, Creppy EE. Lipid peroxidation as pathway of aluminum cytotoxicity in human skin fibroblast cultures: prevention by superoxide dismutase and catalase and vitamins E and C. Hum Exp Toxicol 2001; 20:477-81.

http://dx.doi.org/10.1191/096032701682693053

[
Pubmed]   


13.El-Demerdash FM, Youself MI, Kedwany FS, Baghidadi HH. Cadmium induced changes in lipid peroxidation blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and beta-carotene. Food Chem Toxicol 2004; 42:1563-71.

http://dx.doi.org/10.1016/j.fct.2004.05.001

[
Pubmed]   


14.O'Brien P, Salaçinski HJ. Evidence that the reactions of cadmium in the presence of metallothionein can produce hydroxyl radicals. Arch Toxicol 1998; 72:690-700.

http://dx.doi.org/10.1007/s002040050562

[
Pubmed]   


15.Guerin P, El Mouatassim S, Menezo Y. Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings. Hum Reprod Update 2001; 7:175-89.

http://dx.doi.org/10.1093/humupd/7.2.175

[
Pubmed]   


16.Samuel BJ. Reproductive toxicity of chromium on ovarian development in female Wistar rats - an endocrine and a biochemical approach. Ph.D. Thesis, 2001.


17.Marklund S, Marklund G. Involvement of superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Chem 1974; 47:469-74.

http://dx.doi.org/10.1111/j.1432-1033.1974.tb03714.x

[
Pubmed]   


18.Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972; 47:389-94.

http://dx.doi.org/10.1016/0003-2697(72)90132-7

[
Pubmed]   


19.Rotruck JT, Pope AC, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidases. Science 1973; 179:588-90.

http://dx.doi.org/10.1126/science.179.4073.588

[
Pubmed]   


20.Habig WH, Pabst MJ, Jakoby WB. Glutathione-S-transferase. The first enzymatic step in mercapturic formation. J Biol Chem 1974; 249:7130-9.

[
Pubmed]   


21.Banu SK, Samuel JB, Arosh JA, Burghardt RC, Aruldhas MM. Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats. Toxicol Appl Pharmacol 2008; 232:180-9.

http://dx.doi.org/10.1016/j.taap.2008.06.002

[
Pubmed]   


22.Samuel JB, Stanley JA, Princess RA, Shanthi P, Sebastian MS. Gestational cadmium exposure induced ovotoxicity delays puberty through oxidative stress and impaired steroid hormone levels. J Med Toxicol; 2011; 7:195-204.

http://dx.doi.org/10.1007/s13181-011-0143-9

[
Pubmed]    [PMC Free Fulltext]   


23.Samuel JB, Stanley JA, Roopha DP, Vengatesh G, Anbalagan J, Banu SK. Lactational hexavalent chromium exposure-induced oxidative stress in rat uterus is associated with delayed puberty and impaired gonadotropin levels. Hum Exp Toxicol 2011; 30:91-101.

http://dx.doi.org/10.1177/0960327110364638

[
Pubmed]   


24.Devasagayam TP, Tarachand V. Decreased lipid peroxidation in the rat kidney during gestation. Biochem Biophys Res Commun 1987; 145:134-8.

http://dx.doi.org/10.1016/0006-291X(87)91297-6

[
Pubmed]   


25.Holland MK, Storey BT. Oxygen metabolism of mammalian spermatozoa. Generation of hydrogen peroxide by rabbit spermatozoa. Biochem J 1981; 198:273-80.

[
Pubmed]    [PMC Free Fulltext]   


26.Fischer RA, Yates F. Statistical Tables for Biological, Agricultural and Medical Research. Oliver and Boyd, London, UK, 1948.

[
PMC Free Fulltext]   


27.Massanyi P, Uhrin V. Histological changes in the ovaries of rabbits after an administration of cadmium. Reprod Dom Anim 1996; 311:629-32.


28.Sorell TL, Graziano JH. Effect of oral cadmium exposure during pregnancy on maternal and fetal zinc metabolism in the rat. Toxicol Appl Pharmacol 1990; 102:537-45.

http://dx.doi.org/10.1016/0041-008X(90)90048-Y

[
Pubmed]   


29.Sutou S, Yamamoto K, Sendota H, Tomomatsu K, Shimizu Y, Sugiyama M. Toxicity, fertility, tetragenicity and dominant lethal tests in rats administered cadmium sub chronically. I. Toxicity Studies. Ecotox Environ Safety 1980; 4:39-50.

http://dx.doi.org/10.1016/0147-6513(80)90006-8


30.Ronis MJ, Badger TM, Shema SJ, Roberson PK, Shaikh F. Reproductive toxicity and growth defects in rats exposed to lead different periods during development. Toxicol Appl Pharmacol 1996; 136:361-71.

http://dx.doi.org/10.1006/taap.1996.0044

[
Pubmed]   


31.Dunnick JK. NTP Technical Report on Toxicity Studies of Cadmium Oxide (CAS No. 1306-19-0) Administered by Inhalation to F344/N Rats and B6C3F Mice. NIH Publication 95-3388, March 1995.


32.Ognjanovic B, Pavlovic SZ, Maletic SD, Zikic RV, Stajn A, Radojicic RM, Saicic ZS, Petrovic VM. Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium. Physiol Res 2003; 52:563-70.

[
Pubmed]   


33.Aruoma OI. Free radicals, oxidative stress and antioxidants in human health and disease. J Am Oil Chem Soc 1998; 75:199-212.

http://dx.doi.org/10.1007/s11746-998-0032-9


34.El-Tohamy MM. Combined therapy with antioxidants against cadmium induced testicular dysfunction in rabbits. XIIth International Congress on Animal Hygiene (ISAH 2005), Warsaw, Poland 4-8 September 2005.


35.Muthusami S, Ramachandran I, Muthusamy B, Vasudevan G, Prabhu V, Subramaniam V. Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats. Clin Chim Acta 2005; 360:81-6.

http://dx.doi.org/10.1016/j.cccn.2005.04.014

[
Pubmed]   


36.Patra RC, Swarup D, Senapati SK. Effects of cadmium on lipid peroxides and superoxide dismutase in hepatic, renal and testicular tissue in rats. Vet Hum Toxicol 1999; 41:65-7.

[
Pubmed]   


37.Sen CK. Nutritional biochemistry of cellular glutathione. J Nutr Biochem 1997; 8:660-72.

http://dx.doi.org/10.1016/S0955-2863(97)00113-7


38.Samanta L, Roy A, Chainy GB. Changes in rat testicular antioxidant defense profile as a function of age and its impairment by hexachlorocyclohexane during critical stages of maturation. Andrologia 1999; 31:83-90.

http://dx.doi.org/10.1111/j.1439-0272.1999.tb02850.x

[
Pubmed]   


39.Djukic-Cosic D, Curcic Jovanovic M, Plamenac Bulat Z, Ninkovic M, Malicevic Z, Matovic V. Relation between lipid peroxidation and iron concentration in mouse liver after acute and subacute cadmium intoxication. J Trace Elem Med Biol. 2008; 22:66-72.

http://dx.doi.org/10.1016/j.jtemb.2007.09.024

[
Pubmed]   


40.Mates M. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 2000; 153:83-104.

http://dx.doi.org/10.1016/S0300-483X(00)00306-1

[
Pubmed]   


41.Caslino E, Sblano C, Landriscina V, Calzaretti G, Landriscina C. Rat liver glutathione-tranferase activity stimulation following acute cadmium or manganese intoxication. Toxicology 2004; 200:29-38.

http://dx.doi.org/10.1016/j.tox.2004.03.004

[
Pubmed]   


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How to Cite this Article
Pubmed Style

Roopha DP, Latha PC. Cadmium exposure-induced oxidative stress; delay in sexual maturation and impaired hormones in developing rat ovary. Oxid Antioxid Med Sci. 2013; 2(3): 181-187. doi:10.5455/oams.1007613.or.048


Web Style

Roopha DP, Latha PC. Cadmium exposure-induced oxidative stress; delay in sexual maturation and impaired hormones in developing rat ovary. http://www.ejmoams.com/?mno=38538 [Access: May 22, 2018]. doi:10.5455/oams.1007613.or.048


AMA (American Medical Association) Style

Roopha DP, Latha PC. Cadmium exposure-induced oxidative stress; delay in sexual maturation and impaired hormones in developing rat ovary. Oxid Antioxid Med Sci. 2013; 2(3): 181-187. doi:10.5455/oams.1007613.or.048



Vancouver/ICMJE Style

Roopha DP, Latha PC. Cadmium exposure-induced oxidative stress; delay in sexual maturation and impaired hormones in developing rat ovary. Oxid Antioxid Med Sci. (2013), [cited May 22, 2018]; 2(3): 181-187. doi:10.5455/oams.1007613.or.048



Harvard Style

Roopha, D. P. & Latha, P. C. (2013) Cadmium exposure-induced oxidative stress; delay in sexual maturation and impaired hormones in developing rat ovary. Oxid Antioxid Med Sci, 2 (3), 181-187. doi:10.5455/oams.1007613.or.048



Turabian Style

Roopha, Dailiah P., and Padma C. Latha. 2013. Cadmium exposure-induced oxidative stress; delay in sexual maturation and impaired hormones in developing rat ovary. Oxidants and Antioxidants in Medical Science, 2 (3), 181-187. doi:10.5455/oams.1007613.or.048



Chicago Style

Roopha, Dailiah P., and Padma C. Latha. "Cadmium exposure-induced oxidative stress; delay in sexual maturation and impaired hormones in developing rat ovary." Oxidants and Antioxidants in Medical Science 2 (2013), 181-187. doi:10.5455/oams.1007613.or.048



MLA (The Modern Language Association) Style

Roopha, Dailiah P., and Padma C. Latha. "Cadmium exposure-induced oxidative stress; delay in sexual maturation and impaired hormones in developing rat ovary." Oxidants and Antioxidants in Medical Science 2.3 (2013), 181-187. Print. doi:10.5455/oams.1007613.or.048



APA (American Psychological Association) Style

Roopha, D. P. & Latha, P. C. (2013) Cadmium exposure-induced oxidative stress; delay in sexual maturation and impaired hormones in developing rat ovary. Oxidants and Antioxidants in Medical Science, 2 (3), 181-187. doi:10.5455/oams.1007613.or.048





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