ISSN 2146-8389
 

Original Research (Original Article) 


Effects of D-004, antioxidant and antiflammatory substances on testosterone-induced prostate hyperplasia in rats

Ambar O. Yera, Yohani P. Guerra, Sonia J. Despaigne, Rosa M. Ferreiro, Vivian M. Cuevas.

Abstract
The aim of this study was to investigate the possible contribution of the anti-inflammatory and antioxidant effects of D-004, the lipid extract of the royal palm (Roystonea regia) fruits, on testosterone-induced prostate hyperplasia (PH) in rats. Rats were randomized into seven groups: a negative control and six groups were injected subcutaneously with testosterone; one of the testosterone-injected groups served as positive control and five were treated with D-004 (400 mg/kg), grape seed extract (GSE) (250 mg/kg), vitamin E (VE) (250 mg/kg), ibuprofen (200 mg/kg) or celecoxib (50 mg/kg) for 14 days. Effects on prostate weight (PW), on rat prostate malondialdehyde (MDA) concentrations and myeloperoxidase (MPO) activity were assessed. The injection of testosterone increased significantly the PW, PW/bodyweight (BW) ratio, MDA concentration and MPO activity in the positive controls as compared to the negative controls. Oral administration of D-004, not of any other treatment, significantly reduced PW and PW/BW ratio as compared to the positive control. D-004, GSE and VE, not ibuprofen or celecoxib, lowered significantly MDA values (82.9, 86 and 98.8%, respectively). In contrast, significant inhibitions of MPO activity were achieved with D-004 (58.5%), GSE (56.1%), ibuprofen (73.8%) and celecoxib (61.5%), not with VE. In conclusion, oral treatment with D-004 (400 mg/kg), but not with the antioxidant and anti-inflammatory substances tested, prevented testosterone-induced PH in rats, so that the preventive effect of D-004 on this model does not seem to be associated to its antioxidant or anti-inflammatory effects.

Key words: Anti-inflammatory; D-004; Prostate hyperplasia; Rat


 
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How to Cite this Article
Pubmed Style

Yera AO, Guerra YP, Despaigne SJ, Ferreiro RM, Cuevas VM. Effects of D-004, antioxidant and antiflammatory substances on testosterone-induced prostate hyperplasia in rats. Oxid Antioxid Med Sci. 2013; 2(3): 189-193. doi:10.5455/oams.070513.or.042


Web Style

Yera AO, Guerra YP, Despaigne SJ, Ferreiro RM, Cuevas VM. Effects of D-004, antioxidant and antiflammatory substances on testosterone-induced prostate hyperplasia in rats. http://www.ejmoams.com/?mno=33229 [Access: May 22, 2018]. doi:10.5455/oams.070513.or.042


AMA (American Medical Association) Style

Yera AO, Guerra YP, Despaigne SJ, Ferreiro RM, Cuevas VM. Effects of D-004, antioxidant and antiflammatory substances on testosterone-induced prostate hyperplasia in rats. Oxid Antioxid Med Sci. 2013; 2(3): 189-193. doi:10.5455/oams.070513.or.042



Vancouver/ICMJE Style

Yera AO, Guerra YP, Despaigne SJ, Ferreiro RM, Cuevas VM. Effects of D-004, antioxidant and antiflammatory substances on testosterone-induced prostate hyperplasia in rats. Oxid Antioxid Med Sci. (2013), [cited May 22, 2018]; 2(3): 189-193. doi:10.5455/oams.070513.or.042



Harvard Style

Yera, A. O., Guerra, Y. P., Despaigne, S. J., Ferreiro, R. M. & Cuevas, V. M. (2013) Effects of D-004, antioxidant and antiflammatory substances on testosterone-induced prostate hyperplasia in rats. Oxid Antioxid Med Sci, 2 (3), 189-193. doi:10.5455/oams.070513.or.042



Turabian Style

Yera, Ambar O., Yohani P. Guerra, Sonia J. Despaigne, Rosa M. Ferreiro, and Vivian M. Cuevas. 2013. Effects of D-004, antioxidant and antiflammatory substances on testosterone-induced prostate hyperplasia in rats. Oxidants and Antioxidants in Medical Science, 2 (3), 189-193. doi:10.5455/oams.070513.or.042



Chicago Style

Yera, Ambar O., Yohani P. Guerra, Sonia J. Despaigne, Rosa M. Ferreiro, and Vivian M. Cuevas. "Effects of D-004, antioxidant and antiflammatory substances on testosterone-induced prostate hyperplasia in rats." Oxidants and Antioxidants in Medical Science 2 (2013), 189-193. doi:10.5455/oams.070513.or.042



MLA (The Modern Language Association) Style

Yera, Ambar O., Yohani P. Guerra, Sonia J. Despaigne, Rosa M. Ferreiro, and Vivian M. Cuevas. "Effects of D-004, antioxidant and antiflammatory substances on testosterone-induced prostate hyperplasia in rats." Oxidants and Antioxidants in Medical Science 2.3 (2013), 189-193. Print. doi:10.5455/oams.070513.or.042



APA (American Psychological Association) Style

Yera, A. O., Guerra, Y. P., Despaigne, S. J., Ferreiro, R. M. & Cuevas, V. M. (2013) Effects of D-004, antioxidant and antiflammatory substances on testosterone-induced prostate hyperplasia in rats. Oxidants and Antioxidants in Medical Science, 2 (3), 189-193. doi:10.5455/oams.070513.or.042





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