ISSN 2146-8389
 

Review Article 


Oxidative stress in cigarette smokers and patients with chronic obstructive pulmonary disease

Shunsuke Taito, Hironobu Hamada, Kiyokazu Sekikawa, Norimichi Kamikawa, Makoto Takahashi.

Abstract
Cigarette smoking is the most important exogenous risk factor for chronic obstructive pulmonary disease (COPD). Oxidative stress induced by smoking is considered to play major roles in the pathogenesis of COPD. In this review, we describe the theory of oxidant/antioxidant imbalance and the cellular and molecular reactions induced by oxidative stress. In addition, we discuss the effects of cigarette smoking on oxidative stress in smokers and patients with COPD.
Smoking leads to increased acute pulmonary and systemic oxidative stress in cigarette smokers. As chronic effects of smoking, both pulmonary and systemic oxidative stress are increased in cigarette smokers and patients with COPD compared to non-smokers, the level of oxidative stress increases in association with duration of smoking history. Furthermore, pulmonary and systemic oxidative stress has been reported to be increased in response to exercise in cigarette smokers with a short smoking history, compared to non-smokers, although no difference was seen in baseline oxidative stress levels.
Cigarette smoking affects the pulmonary and systemic oxidative stress response even in cigarette smokers with a short smoking history as well as smokers with a long smoking history and COPD patients.

Key words: Chronic obstructive pulmonary disease, oxidant/antioxidant imbalance, smokers, smoking cessation


 
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Pubmed Style

Taito S, Hamada H, Sekikawa K, Kamikawa N, Takahashi M. Oxidative stress in cigarette smokers and patients with chronic obstructive pulmonary disease. Oxid Antioxid Med Sci. 2017; 6(2): 19-24. doi:10.5455/oams.050417.rv.026


Web Style

Taito S, Hamada H, Sekikawa K, Kamikawa N, Takahashi M. Oxidative stress in cigarette smokers and patients with chronic obstructive pulmonary disease. http://www.ejmoams.com/?mno=255190 [Access: October 16, 2018]. doi:10.5455/oams.050417.rv.026


AMA (American Medical Association) Style

Taito S, Hamada H, Sekikawa K, Kamikawa N, Takahashi M. Oxidative stress in cigarette smokers and patients with chronic obstructive pulmonary disease. Oxid Antioxid Med Sci. 2017; 6(2): 19-24. doi:10.5455/oams.050417.rv.026



Vancouver/ICMJE Style

Taito S, Hamada H, Sekikawa K, Kamikawa N, Takahashi M. Oxidative stress in cigarette smokers and patients with chronic obstructive pulmonary disease. Oxid Antioxid Med Sci. (2017), [cited October 16, 2018]; 6(2): 19-24. doi:10.5455/oams.050417.rv.026



Harvard Style

Taito, S., Hamada, H., Sekikawa, K., Kamikawa, N. & Takahashi, M. (2017) Oxidative stress in cigarette smokers and patients with chronic obstructive pulmonary disease. Oxid Antioxid Med Sci, 6 (2), 19-24. doi:10.5455/oams.050417.rv.026



Turabian Style

Taito, Shunsuke, Hironobu Hamada, Kiyokazu Sekikawa, Norimichi Kamikawa, and Makoto Takahashi. 2017. Oxidative stress in cigarette smokers and patients with chronic obstructive pulmonary disease. Oxidants and Antioxidants in Medical Science, 6 (2), 19-24. doi:10.5455/oams.050417.rv.026



Chicago Style

Taito, Shunsuke, Hironobu Hamada, Kiyokazu Sekikawa, Norimichi Kamikawa, and Makoto Takahashi. "Oxidative stress in cigarette smokers and patients with chronic obstructive pulmonary disease." Oxidants and Antioxidants in Medical Science 6 (2017), 19-24. doi:10.5455/oams.050417.rv.026



MLA (The Modern Language Association) Style

Taito, Shunsuke, Hironobu Hamada, Kiyokazu Sekikawa, Norimichi Kamikawa, and Makoto Takahashi. "Oxidative stress in cigarette smokers and patients with chronic obstructive pulmonary disease." Oxidants and Antioxidants in Medical Science 6.2 (2017), 19-24. Print. doi:10.5455/oams.050417.rv.026



APA (American Psychological Association) Style

Taito, S., Hamada, H., Sekikawa, K., Kamikawa, N. & Takahashi, M. (2017) Oxidative stress in cigarette smokers and patients with chronic obstructive pulmonary disease. Oxidants and Antioxidants in Medical Science, 6 (2), 19-24. doi:10.5455/oams.050417.rv.026





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