ISSN 2146-8389
 

Original Research (Original Article) 


Assessment of the in vitro anti-lipid peroxidative activity of Costus afer stem extract

Solomon Ndoni, Diepreye Ere, Tebekeme Okoko.

Abstract
Objective: Costus afer is a perennial monocot consumed as a remedy for various ailments. The present study investigates the effect of Costus afer stem extract on ferrous/ascorbate-induced lipid peroxidation in rat brain, liver and kidney homogenates. The inherent antioxidant and free radical scavenging potentials of the extract were also assessed using various in-vitro models.
Methods: Homogenates of isolated tissues were prepared and lipid peroxidation was induced using the ferrous/ascorbate system and subsequently incubated with various concentrations of the extract. The ability of the methanolic extract to scavenge hydroxyl radicals, hydrogen peroxide and its ability to reduce ferric ions were investigated. The total antioxidant potential via the phosphomolybdate method was also measured.
Results: The results revealed that Costus afer stem extract reduced tissue lipid peroxidation induced by ferrous/ascorbate. The extract also possessed significant antioxidant/free radical scavenging activity via the other in vitro models. In all cases, the effects were concentration-dependent.
Conclusion: The methanolic extract of Costus afer stem possessed significant antioxidant potential ascribable to important phytochemicals and could protect cells/tissues from reactive oxygen species-induced damage. Thus the plant has high pharmacological and ethnobotanical prospects.

Key words: Costus afer, hydroxyl radical, lipid peroxidation, phytochemicals


 
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Pubmed Style

Ndoni S, Ere D, Okoko T. Assessment of the in vitro anti-lipid peroxidative activity of Costus afer stem extract. Oxid Antioxid Med Sci. 2017; 6(2): 30-34. doi:10.5455/oams.130417.or.105


Web Style

Ndoni S, Ere D, Okoko T. Assessment of the in vitro anti-lipid peroxidative activity of Costus afer stem extract. http://www.ejmoams.com/?mno=254805 [Access: August 18, 2018]. doi:10.5455/oams.130417.or.105


AMA (American Medical Association) Style

Ndoni S, Ere D, Okoko T. Assessment of the in vitro anti-lipid peroxidative activity of Costus afer stem extract. Oxid Antioxid Med Sci. 2017; 6(2): 30-34. doi:10.5455/oams.130417.or.105



Vancouver/ICMJE Style

Ndoni S, Ere D, Okoko T. Assessment of the in vitro anti-lipid peroxidative activity of Costus afer stem extract. Oxid Antioxid Med Sci. (2017), [cited August 18, 2018]; 6(2): 30-34. doi:10.5455/oams.130417.or.105



Harvard Style

Ndoni, S., Ere, D. & Okoko, T. (2017) Assessment of the in vitro anti-lipid peroxidative activity of Costus afer stem extract. Oxid Antioxid Med Sci, 6 (2), 30-34. doi:10.5455/oams.130417.or.105



Turabian Style

Ndoni, Solomon, Diepreye Ere, and Tebekeme Okoko. 2017. Assessment of the in vitro anti-lipid peroxidative activity of Costus afer stem extract. Oxidants and Antioxidants in Medical Science, 6 (2), 30-34. doi:10.5455/oams.130417.or.105



Chicago Style

Ndoni, Solomon, Diepreye Ere, and Tebekeme Okoko. "Assessment of the in vitro anti-lipid peroxidative activity of Costus afer stem extract." Oxidants and Antioxidants in Medical Science 6 (2017), 30-34. doi:10.5455/oams.130417.or.105



MLA (The Modern Language Association) Style

Ndoni, Solomon, Diepreye Ere, and Tebekeme Okoko. "Assessment of the in vitro anti-lipid peroxidative activity of Costus afer stem extract." Oxidants and Antioxidants in Medical Science 6.2 (2017), 30-34. Print. doi:10.5455/oams.130417.or.105



APA (American Psychological Association) Style

Ndoni, S., Ere, D. & Okoko, T. (2017) Assessment of the in vitro anti-lipid peroxidative activity of Costus afer stem extract. Oxidants and Antioxidants in Medical Science, 6 (2), 30-34. doi:10.5455/oams.130417.or.105





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