ISSN 2146-8389
 

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Multivariate discriminant analysis of redox and progression indexes in Cuban AIDS patients with Kaposi's sarcoma

Lizette Gil del Valle, Milena Duque-Vizcaino, Vianka Calas-Hechavarria, Rosario Gravier-Hernandez, Narciso Jimenez-Perez, Yusimit Bermudez-Alfonso, Dayme Hernandez-Requejo, Daniel Gonzalez-Rubio.

Abstract
Objectives: Infection by human immunodeficiency virus (HIV) generates sustained reactive oxygen species production. An increasing number of studies underline the pathogenic impact of high-grade local and systemic oxidative stress in the activation of Herpes virus 8 producing Kaposi's sarcoma (KS) co-infection in acquired immunodeficiency syndrome (AIDS) patients. The present study aimed to determine the redox status in AIDS-KS Cuban individuals and to explore the relation between redox and progression variables.
Methods: Blood samples were drawn from 99 individuals divided into three groups (33 each one; age range 30-50 years): AIDS, AIDS-KS and presumable healthy subjects. Total peroxide, malondialdehyde and advanced oxidation protein products as damage indexes and antioxidant responses (glutathione, peroxidation potential, superoxide dismutase and catalase) were determined from the blood samples. Also hematological and hemochemical indexes, progression indexes (viral load, CD4+ T lymphocyte absolute count) and tumoral progression indexes were assessed. Different statistical analyses were done.
Results: Compared to healthy subjects, both groups of AIDS patients had significant differences in global indices of damage and antioxidant status. The comparison between the groups revealed that AIDS-KS group had a significantly higher damage and lower antioxidant status compared to the healthy control and AIDS groupís. Multivariate statistical analysis clearly separated groups according progression indexes and redox profile, obtaining two canonical functions.
Conclusions: These results corroborate that substantial oxidative stress occurs in AIDS condition and also during KS-HIV co-infection with different molecular extension and interdependence to progression indexes. Redox indexes diagnosis should be considered in early diagnostics, prevention and treatment of KS-HIV co-infection, which would be worthwhile to conduct a more comprehensive study and manage of infection.

Key words: AIDS, early diagnosis, HIV, Kaposi's sarcoma


 
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Pubmed Style

Lizette Gil del Valle, Milena Duque-Vizcaino, Vianka Calas-Hechavarria, Rosario Gravier-Hernandez, Narciso Jimenez-Perez, Yusimit Bermudez-Alfonso, Dayme Hernandez-Requejo, Daniel Gonzalez-Rubio. Multivariate discriminant analysis of redox and progression indexes in Cuban AIDS patients with Kaposi's sarcoma. Oxid Antioxid Med Sci. 2017; 6(1): 1-8. doi:10.5455/oams.210317.or.102


Web Style

Lizette Gil del Valle, Milena Duque-Vizcaino, Vianka Calas-Hechavarria, Rosario Gravier-Hernandez, Narciso Jimenez-Perez, Yusimit Bermudez-Alfonso, Dayme Hernandez-Requejo, Daniel Gonzalez-Rubio. Multivariate discriminant analysis of redox and progression indexes in Cuban AIDS patients with Kaposi's sarcoma. http://www.ejmoams.com/?mno=246162 [Access: December 19, 2018]. doi:10.5455/oams.210317.or.102


AMA (American Medical Association) Style

Lizette Gil del Valle, Milena Duque-Vizcaino, Vianka Calas-Hechavarria, Rosario Gravier-Hernandez, Narciso Jimenez-Perez, Yusimit Bermudez-Alfonso, Dayme Hernandez-Requejo, Daniel Gonzalez-Rubio. Multivariate discriminant analysis of redox and progression indexes in Cuban AIDS patients with Kaposi's sarcoma. Oxid Antioxid Med Sci. 2017; 6(1): 1-8. doi:10.5455/oams.210317.or.102



Vancouver/ICMJE Style

Lizette Gil del Valle, Milena Duque-Vizcaino, Vianka Calas-Hechavarria, Rosario Gravier-Hernandez, Narciso Jimenez-Perez, Yusimit Bermudez-Alfonso, Dayme Hernandez-Requejo, Daniel Gonzalez-Rubio. Multivariate discriminant analysis of redox and progression indexes in Cuban AIDS patients with Kaposi's sarcoma. Oxid Antioxid Med Sci. (2017), [cited December 19, 2018]; 6(1): 1-8. doi:10.5455/oams.210317.or.102



Harvard Style

Lizette Gil del Valle, Milena Duque-Vizcaino, Vianka Calas-Hechavarria, Rosario Gravier-Hernandez, Narciso Jimenez-Perez, Yusimit Bermudez-Alfonso, Dayme Hernandez-Requejo, Daniel Gonzalez-Rubio (2017) Multivariate discriminant analysis of redox and progression indexes in Cuban AIDS patients with Kaposi's sarcoma. Oxid Antioxid Med Sci, 6 (1), 1-8. doi:10.5455/oams.210317.or.102



Turabian Style

Lizette Gil del Valle, Milena Duque-Vizcaino, Vianka Calas-Hechavarria, Rosario Gravier-Hernandez, Narciso Jimenez-Perez, Yusimit Bermudez-Alfonso, Dayme Hernandez-Requejo, Daniel Gonzalez-Rubio. 2017. Multivariate discriminant analysis of redox and progression indexes in Cuban AIDS patients with Kaposi's sarcoma. Oxidants and Antioxidants in Medical Science, 6 (1), 1-8. doi:10.5455/oams.210317.or.102



Chicago Style

Lizette Gil del Valle, Milena Duque-Vizcaino, Vianka Calas-Hechavarria, Rosario Gravier-Hernandez, Narciso Jimenez-Perez, Yusimit Bermudez-Alfonso, Dayme Hernandez-Requejo, Daniel Gonzalez-Rubio. "Multivariate discriminant analysis of redox and progression indexes in Cuban AIDS patients with Kaposi's sarcoma." Oxidants and Antioxidants in Medical Science 6 (2017), 1-8. doi:10.5455/oams.210317.or.102



MLA (The Modern Language Association) Style

Lizette Gil del Valle, Milena Duque-Vizcaino, Vianka Calas-Hechavarria, Rosario Gravier-Hernandez, Narciso Jimenez-Perez, Yusimit Bermudez-Alfonso, Dayme Hernandez-Requejo, Daniel Gonzalez-Rubio. "Multivariate discriminant analysis of redox and progression indexes in Cuban AIDS patients with Kaposi's sarcoma." Oxidants and Antioxidants in Medical Science 6.1 (2017), 1-8. Print. doi:10.5455/oams.210317.or.102



APA (American Psychological Association) Style

Lizette Gil del Valle, Milena Duque-Vizcaino, Vianka Calas-Hechavarria, Rosario Gravier-Hernandez, Narciso Jimenez-Perez, Yusimit Bermudez-Alfonso, Dayme Hernandez-Requejo, Daniel Gonzalez-Rubio (2017) Multivariate discriminant analysis of redox and progression indexes in Cuban AIDS patients with Kaposi's sarcoma. Oxidants and Antioxidants in Medical Science, 6 (1), 1-8. doi:10.5455/oams.210317.or.102





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