Oxidants and Antioxidants in Medical Science

2018, Vol: 7, Issue: 2

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Original Research (Original Article)

Oxid Antioxid Med Sci. 2012; 1(3): 161-167

doi: 10.5455/oams.031212.or.024

Association of oxidative stress with mortality: the Beaver Dam Eye Study

Ayleen Godreau, Kristine E. Lee, Barbara E. K. Klein, Anoop Shankar, Michael Y. Tsai, Ronald Klein.

Cited by (3)

Abstract
Epidemiological studies have shown that oxidative stress is associated with cardiovascular disease (CVD) and diabetes. However, the association of oxidative stress marker with non-CVD and CVD mortality has not been extensively evaluated. The association of baseline serum 8-isoprostane (8-ISO) with all-cause, non-CVD, and CVD mortality was examined in a random subset (n = 1,753) of a population-based study of 4,926 adults (99% non-Hispanic whites; 56% women) aged 43-86 years from the Beaver Dam Eye Study. Cause of death was ascertained by death certificate between 1987 and 2002. 8-ISO was measured by immunoassay. Cox proportional hazards regression analysis was used to estimate mortality hazard ratios (HRs) and 95% confidence intervals (CIs) by one 8-ISO standard deviation. During a median follow-up of 13.1 years, 590 (33.7%) participants died (290 CVD deaths). After adjusting for socio-demographics and CVD risk factors, 8-ISO was significantly associated with all-cause (HR = 1.1, 95% CI 1.01-1.2) and non-CVD (HR = 1.14, 95% CI 1.01-1.28) mortality but not with CVD mortality (HR = 1.06, 95% CI 0.93-1.2). When limited to participants with BMI < 25 kg/m�, individuals in the highest 8-ISO quartile had approximately 34 to 36% increased risk of all-cause, non-CVD, and CVD death compared to those at the lowest quartile. In contrast, 8-ISO was not significantly associated with mortality among those with BMI ≥ 25 kg/m�. These findings suggest that baseline serum 8-ISO, a marker of oxidative stress, is an independent risk factor of all-cause, non-CVD, and CVD mortality among a cohort of middle-aged adults with normal BMI.

Key words: Cardiovascular disease; Isoprostane; Mortality; Oxidative stress

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REFERENCES

This Article Cited By the following articles

Prediction of myocardial infarction, stroke and cardiovascular mortality with urinary biomarkers of oxidative stress: Results from a large cohort study International Journal of Cardiology 2018; (): .	1

Residual thromboxane activity and oxidative stress Coronary Artery Disease 2017; 28(4): 287.	2

Sleep duration, nightshift work, and the timing of meals and urinary levels of 8-isoprostane and 6-sulfatoxymelatonin in Japanese women Chronobiology International 2017; (): 1.	3

How to Cite this Article

Pubmed Style

Ayleen Godreau, Kristine E. Lee, Barbara E. K. Klein, Anoop Shankar, Michael Y. Tsai, Ronald Klein. Association of oxidative stress with mortality: the Beaver Dam Eye Study. Oxid Antioxid Med Sci. 2012; 1(3): 161-167. doi:10.5455/oams.031212.or.024

Web Style

Ayleen Godreau, Kristine E. Lee, Barbara E. K. Klein, Anoop Shankar, Michael Y. Tsai, Ronald Klein. Association of oxidative stress with mortality: the Beaver Dam Eye Study. http://www.ejmoams.com/?mno=24364 [Access: November 16, 2018]. doi:10.5455/oams.031212.or.024

AMA (American Medical Association) Style

Ayleen Godreau, Kristine E. Lee, Barbara E. K. Klein, Anoop Shankar, Michael Y. Tsai, Ronald Klein. Association of oxidative stress with mortality: the Beaver Dam Eye Study. Oxid Antioxid Med Sci. 2012; 1(3): 161-167. doi:10.5455/oams.031212.or.024

Vancouver/ICMJE Style

Ayleen Godreau, Kristine E. Lee, Barbara E. K. Klein, Anoop Shankar, Michael Y. Tsai, Ronald Klein. Association of oxidative stress with mortality: the Beaver Dam Eye Study. Oxid Antioxid Med Sci. (2012), [cited November 16, 2018]; 1(3): 161-167. doi:10.5455/oams.031212.or.024

Harvard Style

Ayleen Godreau, Kristine E. Lee, Barbara E. K. Klein, Anoop Shankar, Michael Y. Tsai, Ronald Klein (2012) Association of oxidative stress with mortality: the Beaver Dam Eye Study. Oxid Antioxid Med Sci, 1 (3), 161-167. doi:10.5455/oams.031212.or.024

Turabian Style

Ayleen Godreau, Kristine E. Lee, Barbara E. K. Klein, Anoop Shankar, Michael Y. Tsai, Ronald Klein. 2012. Association of oxidative stress with mortality: the Beaver Dam Eye Study. Oxidants and Antioxidants in Medical Science, 1 (3), 161-167. doi:10.5455/oams.031212.or.024

Chicago Style

Ayleen Godreau, Kristine E. Lee, Barbara E. K. Klein, Anoop Shankar, Michael Y. Tsai, Ronald Klein. "Association of oxidative stress with mortality: the Beaver Dam Eye Study." Oxidants and Antioxidants in Medical Science 1 (2012), 161-167. doi:10.5455/oams.031212.or.024

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Ayleen Godreau, Kristine E. Lee, Barbara E. K. Klein, Anoop Shankar, Michael Y. Tsai, Ronald Klein (2012) Association of oxidative stress with mortality: the Beaver Dam Eye Study. Oxidants and Antioxidants in Medical Science, 1 (3), 161-167. doi:10.5455/oams.031212.or.024

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