ISSN 2146-8389
 

Invited Review 


The potential role of S-allylcysteine as antioxidant against various disorders in animal models

V. V. Sathibabu Uddandrao, Parim Brahmanaidu, Balaji Meriga, Ganapathy Saravanan.

Cited by (3)

Abstract
Successful regulation of cellular equilibrium among oxidation and anti-oxidation is significant for cellular function and DNA integrity as well as gene expression for signal transduction. Numerous pathological processes, such as cancer, diabetes, heart and/or kidney diseases, Parkinson’s and Alzheimer’s diseases, have been revealed to be associated to the redox state of cells.
In a challenge to curtail the onset of oxidative stress, administration with diverse recognized antioxidants has been recommended. Glutathione (GSH) is accepted for its capability to reduce oxidative stress and downstream the harmful effects such as lipid peroxidation. Antioxidants thus play a significant part in protecting the human body against the damage caused by reactive oxygen species. S-Allylcysteine (SAC), a sulfur containing amino acid derived from garlic, has been experimentally demonstrated to possess antioxidant and other beneficial activities.
In the present review, we addressed the therapeutic effects of SAC as a potential antioxidant on various disorders by increasing GSH and other antioxidants. Authenticated with a number of in vivo, in vitro, animal experiments and some human clinical trials, beneficial effects of SAC were reported in cancer, neurodegeneration, nephrotoxicity, ischemic stroke, myocardial infarction and other heart diseases, Alzheimer’s disease, Parkinson’s disease, preeclampsia and diabetes mellitus. On the other hand, there is no scientific evidence against SAC for having adverse effects.

Key words: Glutathione, glutathione reductase, lipid peroxidation, S-allylcysteine


 
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This Article Cited By the following articles

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Obesity-alleviating potential of asiatic acid and its effects on ACC1, UCP2, and CPT1 mRNA expression in high fat diet-induced obese Sprague–Dawley rats
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How to Cite this Article
Pubmed Style

Uddandrao VVS, Brahmanaidu P, Meriga B, Saravanan G. The potential role of S-allylcysteine as antioxidant against various disorders in animal models. Oxid Antioxid Med Sci. 2016; 5(3): 79-86. doi:10.5455/oams.240716.rv.025


Web Style

Uddandrao VVS, Brahmanaidu P, Meriga B, Saravanan G. The potential role of S-allylcysteine as antioxidant against various disorders in animal models. http://www.ejmoams.com/?mno=232307 [Access: August 20, 2018]. doi:10.5455/oams.240716.rv.025


AMA (American Medical Association) Style

Uddandrao VVS, Brahmanaidu P, Meriga B, Saravanan G. The potential role of S-allylcysteine as antioxidant against various disorders in animal models. Oxid Antioxid Med Sci. 2016; 5(3): 79-86. doi:10.5455/oams.240716.rv.025



Vancouver/ICMJE Style

Uddandrao VVS, Brahmanaidu P, Meriga B, Saravanan G. The potential role of S-allylcysteine as antioxidant against various disorders in animal models. Oxid Antioxid Med Sci. (2016), [cited August 20, 2018]; 5(3): 79-86. doi:10.5455/oams.240716.rv.025



Harvard Style

Uddandrao, V. V. S., Brahmanaidu, P., Meriga, B. & Saravanan, G. (2016) The potential role of S-allylcysteine as antioxidant against various disorders in animal models. Oxid Antioxid Med Sci, 5 (3), 79-86. doi:10.5455/oams.240716.rv.025



Turabian Style

Uddandrao, V. V. Sathibabu, Parim Brahmanaidu, Balaji Meriga, and Ganapathy Saravanan. 2016. The potential role of S-allylcysteine as antioxidant against various disorders in animal models. Oxidants and Antioxidants in Medical Science, 5 (3), 79-86. doi:10.5455/oams.240716.rv.025



Chicago Style

Uddandrao, V. V. Sathibabu, Parim Brahmanaidu, Balaji Meriga, and Ganapathy Saravanan. "The potential role of S-allylcysteine as antioxidant against various disorders in animal models." Oxidants and Antioxidants in Medical Science 5 (2016), 79-86. doi:10.5455/oams.240716.rv.025



MLA (The Modern Language Association) Style

Uddandrao, V. V. Sathibabu, Parim Brahmanaidu, Balaji Meriga, and Ganapathy Saravanan. "The potential role of S-allylcysteine as antioxidant against various disorders in animal models." Oxidants and Antioxidants in Medical Science 5.3 (2016), 79-86. Print. doi:10.5455/oams.240716.rv.025



APA (American Psychological Association) Style

Uddandrao, V. V. S., Brahmanaidu, P., Meriga, B. & Saravanan, G. (2016) The potential role of S-allylcysteine as antioxidant against various disorders in animal models. Oxidants and Antioxidants in Medical Science, 5 (3), 79-86. doi:10.5455/oams.240716.rv.025





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