ISSN 2146-8389
 

Original Research (Original Article) 


Peroxidative index as novel marker of hydrogen peroxide involvement in lipid peroxidation from coal dust exposure

Nia Kania, Bambang Setiawan, Edi Widjajanto, Nurdiana Nurdiana, M. Aris Widodo, H.M.S. Chandra Kusuma.

Cited by (8)

Abstract
This study aimed to elucidate whether inhalation of particulate matter 10 (PM10) coal dust change oxidative stress and peroxidative index in rats. A total of 42 Wistar male rats were randomly divided into seven groups including one control group, three groups exposed to coal dust for 14 days, and three groups exposed to coal dust for 28 days. The three groups at the 14 and 28 days exposures received a dose of coal dust equal to 6.25 mg/m3, 12.5 mg/m3, and 25 mg/m3, respectively. The exposure to coal dust exposure was conducted using equipment that was designed in Pharmacology Laboratory, Medical Faculty, Brawijaya University of Malang, Indonesia. ANOVA test was used to analyze the different level of lipid peroxidation, hydrogen peroxide, and peroxidative index. The number of macrophage was significantly higher in 14 and 28 days coal dust exposure groups compared with control group. The level of lung malondialdehyde, bronchoalveolar lavage malondialdehyde, and peroxidative index were significantly higher in 14 and 28 days coal dust exposure groups compared with control group. The level of bronchoalveolar lavage hydrogen peroxide was not significantly difference in all group. We concluded that inhalation of PM10 coal dust increase lung and bronchoalveolar lavage lipid peroxidation, and also peroxidative index of rats.

Key words: Bronchoalveoli; Coal dust; Lung; Particulatte matter 10


 
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How to Cite this Article
Pubmed Style

Kania N, Setiawan B, Widjajanto E, Nurdiana N, Widodo MA, Kusuma HC. Peroxidative index as novel marker of hydrogen peroxide involvement in lipid peroxidation from coal dust exposure. Oxid Antioxid Med Sci. 2012; 1(3): 209-215. doi:10.5455/oams.031012.or.020


Web Style

Kania N, Setiawan B, Widjajanto E, Nurdiana N, Widodo MA, Kusuma HC. Peroxidative index as novel marker of hydrogen peroxide involvement in lipid peroxidation from coal dust exposure. http://www.ejmoams.com/?mno=23018 [Access: June 18, 2018]. doi:10.5455/oams.031012.or.020


AMA (American Medical Association) Style

Kania N, Setiawan B, Widjajanto E, Nurdiana N, Widodo MA, Kusuma HC. Peroxidative index as novel marker of hydrogen peroxide involvement in lipid peroxidation from coal dust exposure. Oxid Antioxid Med Sci. 2012; 1(3): 209-215. doi:10.5455/oams.031012.or.020



Vancouver/ICMJE Style

Kania N, Setiawan B, Widjajanto E, Nurdiana N, Widodo MA, Kusuma HC. Peroxidative index as novel marker of hydrogen peroxide involvement in lipid peroxidation from coal dust exposure. Oxid Antioxid Med Sci. (2012), [cited June 18, 2018]; 1(3): 209-215. doi:10.5455/oams.031012.or.020



Harvard Style

Kania, N., Setiawan, B., Widjajanto, E., Nurdiana, N., Widodo, M. A. & Kusuma, H. C. (2012) Peroxidative index as novel marker of hydrogen peroxide involvement in lipid peroxidation from coal dust exposure. Oxid Antioxid Med Sci, 1 (3), 209-215. doi:10.5455/oams.031012.or.020



Turabian Style

Kania, Nia, Bambang Setiawan, Edi Widjajanto, Nurdiana Nurdiana, M. Aris Widodo, and H.M.S. Chandra Kusuma. 2012. Peroxidative index as novel marker of hydrogen peroxide involvement in lipid peroxidation from coal dust exposure. Oxidants and Antioxidants in Medical Science, 1 (3), 209-215. doi:10.5455/oams.031012.or.020



Chicago Style

Kania, Nia, Bambang Setiawan, Edi Widjajanto, Nurdiana Nurdiana, M. Aris Widodo, and H.M.S. Chandra Kusuma. "Peroxidative index as novel marker of hydrogen peroxide involvement in lipid peroxidation from coal dust exposure." Oxidants and Antioxidants in Medical Science 1 (2012), 209-215. doi:10.5455/oams.031012.or.020



MLA (The Modern Language Association) Style

Kania, Nia, Bambang Setiawan, Edi Widjajanto, Nurdiana Nurdiana, M. Aris Widodo, and H.M.S. Chandra Kusuma. "Peroxidative index as novel marker of hydrogen peroxide involvement in lipid peroxidation from coal dust exposure." Oxidants and Antioxidants in Medical Science 1.3 (2012), 209-215. Print. doi:10.5455/oams.031012.or.020



APA (American Psychological Association) Style

Kania, N., Setiawan, B., Widjajanto, E., Nurdiana, N., Widodo, M. A. & Kusuma, H. C. (2012) Peroxidative index as novel marker of hydrogen peroxide involvement in lipid peroxidation from coal dust exposure. Oxidants and Antioxidants in Medical Science, 1 (3), 209-215. doi:10.5455/oams.031012.or.020





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