ISSN 2146-8389
 

Original Research (Original Article) 


Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro

Jacob K. Akintunde, Daniel G. Akintunde, Emmanuel A. Irondi, Kehinde Babaita, Ramat Labaika, Ojo Sunday.

Abstract
Objective: Bioactive ingredients of plants have been used as a central source of medicine and chemo-therapies for centuries. Nevertheless, the quantification and characterization of phytochemicals in methanol extract stem bark of Kigelia africana (MESBKA) will be highly advantageous if found affirmative.
Methods: MESBKA was taken for gas chromatography-mass spectrometry (GC-MS) analysis. Thereafter, its effect on pro-oxidant induced hydroxyl radical and lipid peroxidation in rat’s testes was evaluated.
Results: The GC-MS analysis provided four peaks of eighteen different active compounds. Also, MESBKA contains antioxidants (polyunsaturated fatty acids, esters and poly alcohols) which are prophylactics of hydroxyl radicals and inhibitors of cyclooxygenase-2 (COX-2) in the testes. Furthermore, MESBKA inhibited pro-oxidants induced hydroxyl radicals and lipid peroxidation in rat’s testes in a dose-dependent manner.
Conclusion: The antioxidant content of Kigelia africana could have prevented inflammatory responses to enhance male fertility in rat. Isolation and translation of individual components of the plant would help to find new drugs to cure and/or prevent male infertility.

Key words: Bioactive compounds, GC-MS, Kigelia africana, male infertility, pro-oxidant


 
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REFERENCES
1. WHO Traditional Medicine Strategy 2014-2023. World Health Organization, Geneva, 2014.
2. Baker JT, Borris RP, Carte B, Cordell GA, Soejarto DD, Cragg GM, Gupta MP, Iwu MM, Madulid DR, Tyler VE. Natural product drug discovery and development: new perspective on international collaboration. J Nat Prod 1995; 58:1325-57. [DOI via Crossref]    [Pubmed]   
3. Kubmarawa D, Ajoku GA, Enwerem NM, Okorie DA. Preliminary phytochemical and antimicrobial screening of 50 medicinal plants from Nigeria. Afri J Biotechnol 2007; 6:1690-6.
4. Geissman TA. Flavonoid compounds, tannins, lignins and related compounds. In: Florkin M, Stotz EH (eds) Pyrrole Pigments, Isoprenoid Compounds and Phenolic Plant Constituents, volume 9. Elsevier, New York, NY, p 265, 1963.
5. Taylor JLS, Rabe T, McGaw LJ, Jager AK, van Staden J. Towards the scientific validation of traditional medicinal plants. Plant Growth Regul 2001; 34:23-37. [DOI via Crossref]   
6. Helen PAM, Aswathy MR, Deepthi KG, Mol RR, Joseph JJ, Sree SJ. Phytochemical analysis and anticancer activity of leaf extract of Mangifera indica (Kottukonam varika). IJPRS 2013; 4:823-8.
7. Severi JA, Lima ZP, Kushima H, Brito AR, Santos LC, Vilegas W, Hiruma-Lima CA. Polyphenols with antiulcerogenic action from aqueous decoction of mango leaves (Mangifera indica L.). Molecules 2009; 14:1098-1110. [DOI via Crossref]    [Pubmed]   
8. Cvetkovic D, Markovic D. Beta-carotene suppression of benzophenone-sensitized lipid peroxidation in hexane through additional chain-breaking activities. Radiat Phys Chem 2011; 80:76-84. [DOI via Crossref]   
9. Juranek I, Bezek, S. Controversy of free radical hypothesis: reactive oxygen species--cause or consequence of tissue injury? Gen Physiol Biophys 2005; 24:263-78.
10. Abioye AIR, Duru FIO, Noronha CC, Okanlawon AO. Aqueous extract of the bark of Kigelia africana reverses early testicular damage induced by methanol extract of Carica papaya. Nigeria J Health Biomed Sci 2003; 2:87-9.
11. Owolabi OJ, Omogbai EKI. Analgesic and anti-inflammatory activities of the ethanolic stem bark extract of Kigelia africana (Bignoniaceae). Afr J Biotechnol 2007; 6:582-5.
12. Grace OM, Light ME, Lindsey KL, Mulholland DA, van Staden J, Jager AK. Antibacterial activity and isolation of active compounds from fruit of the traditional African medicinal tree Kigelia africana. South Afr J Botany 2002; 68:220-2. [DOI via Crossref]   
13. Oyelami OA, Yusuf KO, Oyelami AO. The use of Kigelia africana in the management of polycystic ovary syndrome (PCOS). Chin Med 2013; 3:1-3 [DOI via Crossref]   
14. Chan EWC, Lim YY, Chew YL. Antioxidant activity of Camellia sinensis leaves and tea from a lowland plantation in Malaysia. Food Chem 2006; 102:1214-22. [DOI via Crossref]   
15. Kale A, Gaikwad S, Mundhe K, Deshpande N, Salvekar J. Quantification of phenolics and flavonoids by spectrophotometer from Juglans regia. IJPBS 2010; 1:1-4.
16. Padmaja G. Evaluation of techniques to reduce assayable tannin and cyanide in Cassava leaves. J Agric Food Chem 1989; 37:712-6. [DOI via Crossref]   
17. Hiai S, Oura H, Nakajima T. Color reaction of some sapogenins and saponins with vanillin and sulphuric acid. Plant Med 1976; 29:116-22. [DOI via Crossref]    [Pubmed]   
18. Makkar HP, Siddhuraju SP, Becker K. Plant Secondary Metabolites. Humana Press, Totowa, NJ, 2007.
19. Benderitter M, Maupoil V, Vergely C, Dalloz F, Briot F, Rochette L. Studies by electron paramagnetic resonance of the importance of iron in the hydroxyl scavenging properties of ascorbic acid in plasma: effects of iron chelators. Fundam Clin Pharmacol 1998; 12:510-6. [DOI via Crossref]    [Pubmed]   
20. Halliwell B, Gutteridge JMC, Arouma OI. The deoxyribose method: simple �test-tube� assay for determination of rate constants for reactions of hydroxyl radicals. Anal Biochem 1987; 165:215-9. [DOI via Crossref]   
21. Ursini F, Maiorino M, Morazzoni P, Roveri A, Pifferi G. A novel antioxidant flavonoid (IdB 1031) affecting molecular mechanisms of cellular activation. Free Radic Biol Med 1994; 16:547-53. [DOI via Crossref]   
22. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95:351-8. [DOI via Crossref]   
23. Zar JH. Biostatistical Analysis. Pearson, 5th international edition, 2009.
24. Saroja K, Elizabeth JD, Gopalakrishnan S. Wound healing activity of the leaves of Dipteracantus patulus (Jacq.) Nees. Pharmacologyonline 2009; 2:462-9.
25. Hemamalini K, Om Prasad Naik K, Ashok P. Anti-inflammatory and analgesic effect of methanolic extract of Anogeissus acuminata leaf. Int J Pharm Biomed Res. 2010; 1:98-101
26. Ahmad F, Khan RA, Rasheed S. Study of analgesic and antiinflammatory activity from plant extracts of Lactuca scariola and Artemisia absinthium. Med J Islamic World Acad Sci 1992: 5:111‐4.
27. Gopalakrishnan S, Saroja K, Elizabeth JD. GC-MS analysis of the methanolic extract of the leaves of Dipteracanthus patulus (Jacq.) Nees. J Chem Pharm Res 2011:3:477-80.
28. Manikandan A, Doss DVA. Antiulcer activity of 50% hydroethanolic leaf extract of Ruellia tuberosa l. and Dipteracanthus patulus (Jaca) on pylorus ligated gastric ulcer model. Res J Pharmacog Phytochem 2009; 1:198-201.
29. Manjamalai A, Narala Y, Haridas A, Grace VMB. Antifungal, antiinflammatory and GC-MS analysis of methanolic extract of Plectranthus amboinicus leaf. Int J Curr Pharm Res 2011; 3:12936.
30. Toraskar MP, Kadam VJ, Kulkarni VM. Synthesis and antimicrobial activity of functional analogues of fluconazole. Int J Pharm Pharm Sci 2010; 2:132-3.
31. Ajay KK. Brief review on cyclopropane analogs: synthesis and their pharmacological applications. Int J Pharm Pharm Sci 2013; 5:467- 72.
32. Ajay KK, Lokanatha RKM, Vasanth KG, Mylarappa BN. A facile route for the synthesis of ethyl N-aryl-2,6-dioxopiperid-3-ene-4- carboxylates and their biological activity. Int J Pharm Pharm Sci 2012; 4:564-8.
33. Cao W, Zhang H, Chen J, Deng H, Shao M, Lei L, Qian J, Zhu Y. A facile preparation of trans-1,2-cyclopropanes containing ptrifluoromethylphenyl group and its application to the construction of pyrazole and cyclopropane ring fused pyridazinone derivatives. Tetrahedron 2008; 64:6670-4. [DOI via Crossref]   
34. Komissarova NG, Belenkova NG, Shitikova OV, Spirikhin LV, Yunusov MS. Cyclopropanation of betulonic acid and its methyl ester with dichlorocarbene generated under phase transfer catalysis conditions. ChemInform 2006; 37:200637154. [DOI via Crossref]    [DOI via Crossref]   
35. Yu XH, Rawat R, Shanklin J. Characterization and analysis of the cotton cyclopropane fatty acid synthase family and their contribution to cyclopropane fatty acid synthesis. BMC Plant Biology 2011; 11:97. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
36. Akintunde JK, Oboh G. Exposure to leachate from municipal battery recycling site: implication as key inhibitor of steroidogenic enzymes and risk factor of prostate damage in rats. Rev Environ Health 2013; 28:203-13.
37. Oboh G, Rocha JBT. Water extractable phytochemicals from Capsicum pubescens (tree pepper) inhibit lipid peroxidation induced by different pro-oxidant agents in brain: in vitro. Eur ood Res Technol 2008; 226:707. [DOI via Crossref]   
38. Siemuri EO, Akintunde JK, Salemcity AJ. Effects of sub-acute methanol extract treatment of Calliandra portoricensis root bark on antioxidant defence capacity in an experimental rat model. J Basic Clin Physiol Pharmacol 2015; 26:375-82. [DOI via Crossref]    [Pubmed]   
39. Oboh G, Ademiluyi AO, Akinyemi AJ. Inhibition of acetylcholinesterase activities and some pro-oxidant induced lipid peroxidation in rat brain by two varieties of ginger (Zingiber officinale). Exp Toxicol Pathol 2012; 64:315-9. [DOI via Crossref]    [Pubmed]   
40. Akintunde JK, Oboh G, Akindahunsi AA. Testicular membrane lipid damage by complex mixture of leachate from municipal battery recycling site as indication of idiophatic male infertility in rat. Interdiscipl Toxicol 2013; 6:192-7. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
41. Akintunde JK, Oboh G. In vitro oxidative damage induced in livers, hearts and kidneys of rats treated with leachate from battery recycling site: evidence for environmental contamination and tissue damage. J Clin Exp Pathol 2012; 2:129.
42. Akintunde JK, Oboh G, Akindahunsi AA. Inhibition of key markers linked with spermatogenesis and cellular ATP by subchronic exposure to leachate in a rat model. Arch Environ Contam Toxicol 2015; 68:159-68. [DOI via Crossref]    [Pubmed]   
43. Muanya CA, Odukoya OA. Lipid peroxidation as index of activity in aphrodisiac herbs. J Plant Sci 2008; 3:92-8. [DOI via Crossref]   
44. Farombi EO, Ugwuezunmba MC, Ezenwadua TT, Oyeyemi MO, Ekor M. Tetracycline-induced reproductive toxicity in male rats: effects of vitamin C and N-acetylcysteine. Exp Toxicol Pathol 2008; 60:77-85. [DOI via Crossref]    [Pubmed]   

How to Cite this Article
Pubmed Style

Akintunde JK, Akintunde DG, Irondi EA, Babaita K, Labaika R, Sunday O. Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro. Oxid Antioxid Med Sci. 2016; 5(2): 63-69. doi:10.5455/oams.240516.or.097


Web Style

Akintunde JK, Akintunde DG, Irondi EA, Babaita K, Labaika R, Sunday O. Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro. http://www.ejmoams.com/?mno=219163 [Access: May 22, 2018]. doi:10.5455/oams.240516.or.097


AMA (American Medical Association) Style

Akintunde JK, Akintunde DG, Irondi EA, Babaita K, Labaika R, Sunday O. Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro. Oxid Antioxid Med Sci. 2016; 5(2): 63-69. doi:10.5455/oams.240516.or.097



Vancouver/ICMJE Style

Akintunde JK, Akintunde DG, Irondi EA, Babaita K, Labaika R, Sunday O. Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro. Oxid Antioxid Med Sci. (2016), [cited May 22, 2018]; 5(2): 63-69. doi:10.5455/oams.240516.or.097



Harvard Style

Akintunde, J. K., Akintunde, D. G., Irondi, E. A., Babaita, K., Labaika, R. & Sunday, O. (2016) Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro. Oxid Antioxid Med Sci, 5 (2), 63-69. doi:10.5455/oams.240516.or.097



Turabian Style

Akintunde, Jacob K., Daniel G. Akintunde, Emmanuel A. Irondi, Kehinde Babaita, Ramat Labaika, and Ojo Sunday. 2016. Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro. Oxidants and Antioxidants in Medical Science, 5 (2), 63-69. doi:10.5455/oams.240516.or.097



Chicago Style

Akintunde, Jacob K., Daniel G. Akintunde, Emmanuel A. Irondi, Kehinde Babaita, Ramat Labaika, and Ojo Sunday. "Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro." Oxidants and Antioxidants in Medical Science 5 (2016), 63-69. doi:10.5455/oams.240516.or.097



MLA (The Modern Language Association) Style

Akintunde, Jacob K., Daniel G. Akintunde, Emmanuel A. Irondi, Kehinde Babaita, Ramat Labaika, and Ojo Sunday. "Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro." Oxidants and Antioxidants in Medical Science 5.2 (2016), 63-69. Print. doi:10.5455/oams.240516.or.097



APA (American Psychological Association) Style

Akintunde, J. K., Akintunde, D. G., Irondi, E. A., Babaita, K., Labaika, R. & Sunday, O. (2016) Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro. Oxidants and Antioxidants in Medical Science, 5 (2), 63-69. doi:10.5455/oams.240516.or.097





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