ISSN 2146-8389
 

Original Research (Original Article) Open Access


Airway antioxidant capacity and pH in chronic obstructive pulmonary disease

Wei Lee, Hsien Loo, Paul S. Thomas.

Cited by (1)

Abstract
Oxidant-antioxidant imbalance is implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Exhaled breath condensate (EBC) is a novel and non-invasive method of assessing the redox status of the local airway in COPD subjects. It was hypothesized that COPD patients have less antioxidant capacity in their local airway as compared to the control subjects. The method involved collecting EBC from control and COPD patients (stable and during an exacerbation). Concentrations of EBC antioxidants, namely Trolox-equivalent antioxidant capacity (TEAC), bilirubin, urate and ascorbate, were analyzed using ELISA and high performance liquid chromatography. The mean TEAC level in the stable COPD group was significantly reduced compared to the ex-smokers & smokers. The COPD group during an exacerbation had a mean bilirubin level of 0.22 0.04 mg/dl, which was significantly lower than the stable COPD group (0.35 0.01 mg/dl), and the non-smoking group (0.35 0.02 mg/dl). Urate and ascorbic acid were undetectable. In conclusion, COPD patients are likely to have increased oxidative stress and reduced antioxidant capacity in their local airways.

Key words: Bilirubin; Exhaled breath condensate; pH; Trolox


 
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This Article Cited By the following articles

Biomarkers in Exhaled Breath Condensate and Serum of Chronic Obstructive Pulmonary Disease and Non-Small-Cell Lung Cancer
International Journal of Chronic Diseases 2013; 2013(): 1.

1
 

How to Cite this Article
Pubmed Style

Lee W, Loo H, Thomas PS. Airway antioxidant capacity and pH in chronic obstructive pulmonary disease. Oxid Antioxid Med Sci. 2012; 1(3): 153-160. doi:10.5455/oams.300812.or.016


Web Style

Lee W, Loo H, Thomas PS. Airway antioxidant capacity and pH in chronic obstructive pulmonary disease. http://www.ejmoams.com/?mno=21852 [Access: February 19, 2018]. doi:10.5455/oams.300812.or.016


AMA (American Medical Association) Style

Lee W, Loo H, Thomas PS. Airway antioxidant capacity and pH in chronic obstructive pulmonary disease. Oxid Antioxid Med Sci. 2012; 1(3): 153-160. doi:10.5455/oams.300812.or.016



Vancouver/ICMJE Style

Lee W, Loo H, Thomas PS. Airway antioxidant capacity and pH in chronic obstructive pulmonary disease. Oxid Antioxid Med Sci. (2012), [cited February 19, 2018]; 1(3): 153-160. doi:10.5455/oams.300812.or.016



Harvard Style

Lee, W., Loo, H. & Thomas, P. S. (2012) Airway antioxidant capacity and pH in chronic obstructive pulmonary disease. Oxid Antioxid Med Sci, 1 (3), 153-160. doi:10.5455/oams.300812.or.016



Turabian Style

Lee, Wei, Hsien Loo, and Paul S. Thomas. 2012. Airway antioxidant capacity and pH in chronic obstructive pulmonary disease. Oxidants and Antioxidants in Medical Science, 1 (3), 153-160. doi:10.5455/oams.300812.or.016



Chicago Style

Lee, Wei, Hsien Loo, and Paul S. Thomas. "Airway antioxidant capacity and pH in chronic obstructive pulmonary disease." Oxidants and Antioxidants in Medical Science 1 (2012), 153-160. doi:10.5455/oams.300812.or.016



MLA (The Modern Language Association) Style

Lee, Wei, Hsien Loo, and Paul S. Thomas. "Airway antioxidant capacity and pH in chronic obstructive pulmonary disease." Oxidants and Antioxidants in Medical Science 1.3 (2012), 153-160. Print. doi:10.5455/oams.300812.or.016



APA (American Psychological Association) Style

Lee, W., Loo, H. & Thomas, P. S. (2012) Airway antioxidant capacity and pH in chronic obstructive pulmonary disease. Oxidants and Antioxidants in Medical Science, 1 (3), 153-160. doi:10.5455/oams.300812.or.016





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