ISSN 2146-8389
 

Original Research (Original Article) 


Oxidative stress in chronic headaches: old and new markers

Andrea Bolner, Giovanni D'Andrea, Ottavio Bosello, Giampietro Nordera.

Abstract
Objective: To study the effects of free radicals’ overproduction in chronic primary headaches, we have evaluated two oxidative stress biomarkers, 3-nitrotyrosine (3-NT) and 8-hydroxy-deoxyguanosine expressed as ratio vs 2-deoxyguanosine (8-OHdG/2-dG).
Methods: Analyses were done in plasma of three groups of subjects: chronic migraine (CM), chronic tension-type headache (CTTH) and healthy controls (CNT). 3-NT was analyzed by ultraviolet high-performance liquid chromatography (HPLC-UV), and 8-OHdG and 2-dG by two similar HPLC methods with electrochemical and fluorimetric detection, respectively.
Results: In comparison to CNT group, 3-NT levels in plasma were significantly higher in CM patients whereas in CTTH were in the same range of healthy subjects. Instead, the mean 8-OHdG/2-dG ratios were higher in both chronic headache groups than CNT but without statistical significance (P values 0.46 and 0.1 for CTTH and CM, respectively).
Conclusion: The higher mean plasmatic levels of 3-NT in CM only, suggest that just in this type of migraine an anomalous production of reactive nitrogen species occurs.

Key words: 2-Deoxyguanosine, 3-nitrotyrosine, 8-hydroxy-deoxyguanosine, chronic migraine, chronic tension-type headache, headache


 
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How to Cite this Article
Pubmed Style

Bolner A, DAndrea G, Bosello O, Nordera G. Oxidative stress in chronic headaches: old and new markers. Oxid Antioxid Med Sci. 2015; 4(3): 119-124. doi:10.5455/oams.231115.or.091


Web Style

Bolner A, DAndrea G, Bosello O, Nordera G. Oxidative stress in chronic headaches: old and new markers. http://www.ejmoams.com/?mno=205323 [Access: August 20, 2018]. doi:10.5455/oams.231115.or.091


AMA (American Medical Association) Style

Bolner A, DAndrea G, Bosello O, Nordera G. Oxidative stress in chronic headaches: old and new markers. Oxid Antioxid Med Sci. 2015; 4(3): 119-124. doi:10.5455/oams.231115.or.091



Vancouver/ICMJE Style

Bolner A, DAndrea G, Bosello O, Nordera G. Oxidative stress in chronic headaches: old and new markers. Oxid Antioxid Med Sci. (2015), [cited August 20, 2018]; 4(3): 119-124. doi:10.5455/oams.231115.or.091



Harvard Style

Bolner, A., DAndrea, G., Bosello, O. & Nordera, G. (2015) Oxidative stress in chronic headaches: old and new markers. Oxid Antioxid Med Sci, 4 (3), 119-124. doi:10.5455/oams.231115.or.091



Turabian Style

Bolner, Andrea, Giovanni DAndrea, Ottavio Bosello, and Giampietro Nordera. 2015. Oxidative stress in chronic headaches: old and new markers. Oxidants and Antioxidants in Medical Science, 4 (3), 119-124. doi:10.5455/oams.231115.or.091



Chicago Style

Bolner, Andrea, Giovanni DAndrea, Ottavio Bosello, and Giampietro Nordera. "Oxidative stress in chronic headaches: old and new markers." Oxidants and Antioxidants in Medical Science 4 (2015), 119-124. doi:10.5455/oams.231115.or.091



MLA (The Modern Language Association) Style

Bolner, Andrea, Giovanni DAndrea, Ottavio Bosello, and Giampietro Nordera. "Oxidative stress in chronic headaches: old and new markers." Oxidants and Antioxidants in Medical Science 4.3 (2015), 119-124. Print. doi:10.5455/oams.231115.or.091



APA (American Psychological Association) Style

Bolner, A., DAndrea, G., Bosello, O. & Nordera, G. (2015) Oxidative stress in chronic headaches: old and new markers. Oxidants and Antioxidants in Medical Science, 4 (3), 119-124. doi:10.5455/oams.231115.or.091





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