ISSN 2146-8389
 

Invited Review Open Access


Oxidative damage and brain atrophy in alcoholics

Emilio Gonzalez-Reimers, Geraldine Quintero-Platt, Camino Fernandez-Rodriguez, Emilio Gonzalez-Arnay, Candelaria Martin-Gonzalez, Onan Perez-Hernandez.

Abstract
Generalized brain atrophy, especially affecting frontal lobes, hippocampus and cerebellum, is frequently observed in alcoholics. This alteration leads to cognitive dysfunction (that may affect 50-80% of alcoholics, even young people) and altered gait and movement disorders.
Although several factors may contribute, oxidative damage, mainly due to increased production of reactive oxygen species plays an outstanding role in its pathogenesis, and will be reviewed in this manuscript. Among them, we can consider mechanisms directly dependent on ethanol metabolism; mechanisms related to increased cytokine secretion, partly dependent on ethanol-induced increased intestinal permeability, endotoxemia and micro RNA induction; mechanisms related to ethanol-mediated iron overload; mechanisms related to ethanol-derived toxic lipid synthesis; and mechanisms related to altered trace element and vitamin concentrations that can affect antioxidant systems.
Despite the role of pro-oxidants, and in contrast with experimental data, no clear-cut benefit has been observed in clinical trials with antioxidants. Alcohol abstinence, together with adequate nutrition, still constitute the most effective therapeutic approach in these patients.

Key words: Encephalopathy, ethanol brain atrophy, cytokines, liver-brain axis, Wernicke´s gut-brain axis


 
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How to Cite this Article
Pubmed Style

Gonzalez-Reimers E, Quintero-Platt G, Fernandez-Rodriguez C, Gonzalez-Arnay E, Martin-Gonzalez C, Perez-Hernandez O. Oxidative damage and brain atrophy in alcoholics. Oxid Antioxid Med Sci. 2015; 4(2): 61-72. doi:10.5455/oams.020615.rv.017


Web Style

Gonzalez-Reimers E, Quintero-Platt G, Fernandez-Rodriguez C, Gonzalez-Arnay E, Martin-Gonzalez C, Perez-Hernandez O. Oxidative damage and brain atrophy in alcoholics. http://www.ejmoams.com/?mno=188535 [Access: February 19, 2018]. doi:10.5455/oams.020615.rv.017


AMA (American Medical Association) Style

Gonzalez-Reimers E, Quintero-Platt G, Fernandez-Rodriguez C, Gonzalez-Arnay E, Martin-Gonzalez C, Perez-Hernandez O. Oxidative damage and brain atrophy in alcoholics. Oxid Antioxid Med Sci. 2015; 4(2): 61-72. doi:10.5455/oams.020615.rv.017



Vancouver/ICMJE Style

Gonzalez-Reimers E, Quintero-Platt G, Fernandez-Rodriguez C, Gonzalez-Arnay E, Martin-Gonzalez C, Perez-Hernandez O. Oxidative damage and brain atrophy in alcoholics. Oxid Antioxid Med Sci. (2015), [cited February 19, 2018]; 4(2): 61-72. doi:10.5455/oams.020615.rv.017



Harvard Style

Gonzalez-Reimers, E., Quintero-Platt, G., Fernandez-Rodriguez, C., Gonzalez-Arnay, E., Martin-Gonzalez, C. & Perez-Hernandez, O. (2015) Oxidative damage and brain atrophy in alcoholics. Oxid Antioxid Med Sci, 4 (2), 61-72. doi:10.5455/oams.020615.rv.017



Turabian Style

Gonzalez-Reimers, Emilio, Geraldine Quintero-Platt, Camino Fernandez-Rodriguez, Emilio Gonzalez-Arnay, Candelaria Martin-Gonzalez, and Onan Perez-Hernandez. 2015. Oxidative damage and brain atrophy in alcoholics. Oxidants and Antioxidants in Medical Science, 4 (2), 61-72. doi:10.5455/oams.020615.rv.017



Chicago Style

Gonzalez-Reimers, Emilio, Geraldine Quintero-Platt, Camino Fernandez-Rodriguez, Emilio Gonzalez-Arnay, Candelaria Martin-Gonzalez, and Onan Perez-Hernandez. "Oxidative damage and brain atrophy in alcoholics." Oxidants and Antioxidants in Medical Science 4 (2015), 61-72. doi:10.5455/oams.020615.rv.017



MLA (The Modern Language Association) Style

Gonzalez-Reimers, Emilio, Geraldine Quintero-Platt, Camino Fernandez-Rodriguez, Emilio Gonzalez-Arnay, Candelaria Martin-Gonzalez, and Onan Perez-Hernandez. "Oxidative damage and brain atrophy in alcoholics." Oxidants and Antioxidants in Medical Science 4.2 (2015), 61-72. Print. doi:10.5455/oams.020615.rv.017



APA (American Psychological Association) Style

Gonzalez-Reimers, E., Quintero-Platt, G., Fernandez-Rodriguez, C., Gonzalez-Arnay, E., Martin-Gonzalez, C. & Perez-Hernandez, O. (2015) Oxidative damage and brain atrophy in alcoholics. Oxidants and Antioxidants in Medical Science, 4 (2), 61-72. doi:10.5455/oams.020615.rv.017





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