ISSN 2146-8389
 

Original Research (Original Article) 


The water extract of Angelica Sinensis Radix protects cultured PC12 cells against oxidative stress: suppression of reactive oxygen species and activation of anti-oxidant response elements

Pinky Sum-Chi Lee, Artemis Lu Yan, Amy Guo-Wei Gong, Roy Chi-Yan Choi, Huang-Quan Lin, Karl Wah-Keung Tsim.

Cited by (1)

Abstract
Objective: Angelica Sinensis Radix (ASR; Dang Gui; the root of Angelica sinensis) is a herbal supplement that has been used in invigorating blood circulation. Here, we provided different lines of evidence to support the beneficial role of ASR against oxidative stress in cultured PC12 cell, a rat pheochromocytoma cell line.
Methods: The water extract of ASR inhibited the activity of xanthine oxidase in vitro. In cultures, the pre-treatment of ASR water extract reduced the cytotoxic effect of tert-butyl hydroperoxide (tBHP), an oxidative stress inducer.
Results: The protecting mechanisms of ASR were shown to be mediated by: (i) suppression of tBHP-induced reactive oxygen species (ROS) formation; (ii) induction of caspase-3 and PARP activities; and (iii) stimulation of mRNAs encoding antioxidative genes, glutathione S-transferase A2 (GSTA2) and NAD(P)H dehydrogenase quinone oxidoreductase 1 (NQO1), via the transcriptional activation of antioxidant response element (ARE). The outcome was the prevention of tBHP-induced cell apoptosis.
Conclusion: Interestingly, the protective effect of ASR extract in PC12 cells were insignificant when challenging by insults of -amlyoid (for Alzheimer’s disease) and MPP+ (for Parkinson’s disease). Taken together, we revealed a neurobeneficial role of ASR in protecting neuronal cells against oxidative damage, which might be useful in developing health food supplements for disease prevention in future.

Key words: Angelica Sinensis Radix, neuroprotection, oxidative stress, reactive oxygen species


 
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This Article Cited By the following articles

Effect of Fermented Herbal Mixture against Oxidative Stress in HepG2 and PC12 Cells
Journal of the Korean Society of Food Science and Nutrition 2016; 45(7): 1057.

1
 
How to Cite this Article
Pubmed Style

Lee PS, Yan AL, Gong AG, Choi RC, Lin H, Tsim KW. The water extract of Angelica Sinensis Radix protects cultured PC12 cells against oxidative stress: suppression of reactive oxygen species and activation of anti-oxidant response elements. Oxid Antioxid Med Sci. 2015; 4(1): 39-48. doi:10.5455/oams.040315.or.082


Web Style

Lee PS, Yan AL, Gong AG, Choi RC, Lin H, Tsim KW. The water extract of Angelica Sinensis Radix protects cultured PC12 cells against oxidative stress: suppression of reactive oxygen species and activation of anti-oxidant response elements. http://www.ejmoams.com/?mno=176449 [Access: October 16, 2018]. doi:10.5455/oams.040315.or.082


AMA (American Medical Association) Style

Lee PS, Yan AL, Gong AG, Choi RC, Lin H, Tsim KW. The water extract of Angelica Sinensis Radix protects cultured PC12 cells against oxidative stress: suppression of reactive oxygen species and activation of anti-oxidant response elements. Oxid Antioxid Med Sci. 2015; 4(1): 39-48. doi:10.5455/oams.040315.or.082



Vancouver/ICMJE Style

Lee PS, Yan AL, Gong AG, Choi RC, Lin H, Tsim KW. The water extract of Angelica Sinensis Radix protects cultured PC12 cells against oxidative stress: suppression of reactive oxygen species and activation of anti-oxidant response elements. Oxid Antioxid Med Sci. (2015), [cited October 16, 2018]; 4(1): 39-48. doi:10.5455/oams.040315.or.082



Harvard Style

Lee, P. S., Yan, A. L., Gong, A. G., Choi, R. C., Lin, H. & Tsim, K. W. (2015) The water extract of Angelica Sinensis Radix protects cultured PC12 cells against oxidative stress: suppression of reactive oxygen species and activation of anti-oxidant response elements. Oxid Antioxid Med Sci, 4 (1), 39-48. doi:10.5455/oams.040315.or.082



Turabian Style

Lee, Pinky Sum-Chi, Artemis Lu Yan, Amy Guo-Wei Gong, Roy Chi-Yan Choi, Huang-Quan Lin, and Karl Wah-Keung Tsim. 2015. The water extract of Angelica Sinensis Radix protects cultured PC12 cells against oxidative stress: suppression of reactive oxygen species and activation of anti-oxidant response elements. Oxidants and Antioxidants in Medical Science, 4 (1), 39-48. doi:10.5455/oams.040315.or.082



Chicago Style

Lee, Pinky Sum-Chi, Artemis Lu Yan, Amy Guo-Wei Gong, Roy Chi-Yan Choi, Huang-Quan Lin, and Karl Wah-Keung Tsim. "The water extract of Angelica Sinensis Radix protects cultured PC12 cells against oxidative stress: suppression of reactive oxygen species and activation of anti-oxidant response elements." Oxidants and Antioxidants in Medical Science 4 (2015), 39-48. doi:10.5455/oams.040315.or.082



MLA (The Modern Language Association) Style

Lee, Pinky Sum-Chi, Artemis Lu Yan, Amy Guo-Wei Gong, Roy Chi-Yan Choi, Huang-Quan Lin, and Karl Wah-Keung Tsim. "The water extract of Angelica Sinensis Radix protects cultured PC12 cells against oxidative stress: suppression of reactive oxygen species and activation of anti-oxidant response elements." Oxidants and Antioxidants in Medical Science 4.1 (2015), 39-48. Print. doi:10.5455/oams.040315.or.082



APA (American Psychological Association) Style

Lee, P. S., Yan, A. L., Gong, A. G., Choi, R. C., Lin, H. & Tsim, K. W. (2015) The water extract of Angelica Sinensis Radix protects cultured PC12 cells against oxidative stress: suppression of reactive oxygen species and activation of anti-oxidant response elements. Oxidants and Antioxidants in Medical Science, 4 (1), 39-48. doi:10.5455/oams.040315.or.082





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    » Abstract & References » doi: 10.5455/oams.270412.or.005
    Cited : 6 times [Click to see citing articles]