ISSN 2146-8389
 

Original Research (Original Article) 


Research of antioxidant properties of theophyllinyl-7-acetic acid derivatives

Katherine Aleksandrova, Igor Belenichev, Alexander Shkoda, Sergey Levich, Darja Yurchenko, Nina Buchtiyarova.

Cited by (2)

Abstract
Objective: Accumulation of reactive oxygen species and nitric oxide (NO) derivatives in the cell exerts damaging effects on its constituents, such as carbohydrates, proteins, lipids, and nucleic acids. These processes has been determined to play a significant role as a nonspecific pathogenetic mechanism in development of multiple disease states, such as atherosclerosis, ischemic stroke, diabetes, etc. The search for antioxidant compounds capable of interrupting the pathological biochemical processes at various steps of oxidative and nitrosative stress development, and thus exerting prophylactic and therapeutic effects, is a priority for medical and pharmaceutical sciences. In this article we investigated the effects of newly synthesized esters, hydrazides and hydrazones of theophyllinyl-7-acetic acid on late markers of oxidative and nitrosative stresses.
Methods: Investigation of antioxidant properties of xanthine derivatives was carried out using following in vitro methods: inhibition of the NO• radical, inhibition of oxidative modification of proteins, and initiation of lipid peroxidation
Results: Hydrazides and benzylidene-hydrazides of theophyllinyl-7-acetic acid showed more pronounced antioxidant properties than esters. The most active compounds among tested theophyllinyl-7-acetic acid derivatives were hydrazide and (1-phenylethyliden)hydrazide of (8-N-benzylaminotheophyllinyl-7)acetic acid.
Conclusions: In vitro studies of 23 derivatives of theophyllinyl-7-acetic acid have been shown that almost all compounds exhibit antioxidant properties. The obtained results also helped us to establish some patterns of structure-activity relationship.

Key words: Esters; Hydrazides; Theophyllinyl-7-acetic acid; Spectroscopy


 
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How to Cite this Article
Pubmed Style

Aleksandrova K, Belenichev I, Shkoda A, Levich S, Yurchenko D, Buchtiyarova N. Research of antioxidant properties of theophyllinyl-7-acetic acid derivatives. Oxid Antioxid Med Sci. 2014; 3(3): 187-194. doi:10.5455/oams.191214.or.078


Web Style

Aleksandrova K, Belenichev I, Shkoda A, Levich S, Yurchenko D, Buchtiyarova N. Research of antioxidant properties of theophyllinyl-7-acetic acid derivatives. http://www.ejmoams.com/?mno=173151 [Access: May 22, 2018]. doi:10.5455/oams.191214.or.078


AMA (American Medical Association) Style

Aleksandrova K, Belenichev I, Shkoda A, Levich S, Yurchenko D, Buchtiyarova N. Research of antioxidant properties of theophyllinyl-7-acetic acid derivatives. Oxid Antioxid Med Sci. 2014; 3(3): 187-194. doi:10.5455/oams.191214.or.078



Vancouver/ICMJE Style

Aleksandrova K, Belenichev I, Shkoda A, Levich S, Yurchenko D, Buchtiyarova N. Research of antioxidant properties of theophyllinyl-7-acetic acid derivatives. Oxid Antioxid Med Sci. (2014), [cited May 22, 2018]; 3(3): 187-194. doi:10.5455/oams.191214.or.078



Harvard Style

Aleksandrova, K., Belenichev, I., Shkoda, A., Levich, S., Yurchenko, D. & Buchtiyarova, N. (2014) Research of antioxidant properties of theophyllinyl-7-acetic acid derivatives. Oxid Antioxid Med Sci, 3 (3), 187-194. doi:10.5455/oams.191214.or.078



Turabian Style

Aleksandrova, Katherine, Igor Belenichev, Alexander Shkoda, Sergey Levich, Darja Yurchenko, and Nina Buchtiyarova. 2014. Research of antioxidant properties of theophyllinyl-7-acetic acid derivatives. Oxidants and Antioxidants in Medical Science, 3 (3), 187-194. doi:10.5455/oams.191214.or.078



Chicago Style

Aleksandrova, Katherine, Igor Belenichev, Alexander Shkoda, Sergey Levich, Darja Yurchenko, and Nina Buchtiyarova. "Research of antioxidant properties of theophyllinyl-7-acetic acid derivatives." Oxidants and Antioxidants in Medical Science 3 (2014), 187-194. doi:10.5455/oams.191214.or.078



MLA (The Modern Language Association) Style

Aleksandrova, Katherine, Igor Belenichev, Alexander Shkoda, Sergey Levich, Darja Yurchenko, and Nina Buchtiyarova. "Research of antioxidant properties of theophyllinyl-7-acetic acid derivatives." Oxidants and Antioxidants in Medical Science 3.3 (2014), 187-194. Print. doi:10.5455/oams.191214.or.078



APA (American Psychological Association) Style

Aleksandrova, K., Belenichev, I., Shkoda, A., Levich, S., Yurchenko, D. & Buchtiyarova, N. (2014) Research of antioxidant properties of theophyllinyl-7-acetic acid derivatives. Oxidants and Antioxidants in Medical Science, 3 (3), 187-194. doi:10.5455/oams.191214.or.078





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