ISSN 2146-8389
 

Original Research (Original Article) Open Access


Antioxidant and anti-inflammatory potential of some dietary cucurbits

Indu Rawat, Dhara Sharma, Harish Chandra Goel.

Cited by (1)

Abstract
Objective: The inflammatory problems and associated diseases in the gastrointestinal tract are known to exist in a sizable fraction of the population. It results due to complex interaction between food, enteric microbes and the host. Therefore, the cucurbits as an easily digestible diet were evaluated for their antioxidant and anti-inflammatory activities.
Methods: Antioxidant properties of cucurbits (Lagenaria siceraria, Ls; Cucurbita pepo, Cp; Luffa cylindrical, Lc) were evaluated in vitro following xylenol orange or Amplex« Red dye method. Anti-inflammatory properties of cucurbits with respect to cyclooxygenase (COX)-1 and 2 were studied and interleukin (IL)-1╬▓ and tumor necrosis factor (TNF)-╬▒ in serum samples of lipopolysaccharide (LPS)-inflamed mice.
Results: The inhibition rate of superoxide radicals by Ls, Cp and Lc was 40, 36 and 31%, respectively, at a concentration of 0.08 mg/ml. The perhydroxyl radical scavenging activity was in a declining order and maximum effect was exhibited by Ls. With respect to COX-1 inhibition, IC50 for indomethacin, Cp, Lc and Ls were estimated to be 0.0154, 0.026, 0.0337 and 0.0335 mg/Ál; and IC50 against COX-2 were 0.0427, 0.023, 0.0183 and 0.0150 mg/Ál, respectively. In vivo study revealed that Ls, Lc, indomethacin and Cp correspondingly down-regulated the expression of IL-1╬▓ by 52, 68, 75 and 126 pg/100 Ál, significantly less than control (260 pg/100 Ál). TNF-╬▒ was also reduced significantly more by Ls, Lc, indomethacin and Cp by 12, 16, 20 and 26 pg/100 Ál, respectively, than control (46 pg/100 Ál).
Conclusion: The dietary cucurbits seem to have potential for developing a non-toxic therapeutic product.

Key words: Cucurbita pepo; Cyclooxygenases; Free radicals; Lagenaria siceraria; Luffa cylindrica


 
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This Article Cited By the following articles

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Appl. Physiol. Nutr. Metab. 2016; 41(12): 1248.

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How to Cite this Article
Pubmed Style

Rawat I, Sharma D, Goel HC. Antioxidant and anti-inflammatory potential of some dietary cucurbits. Oxid Antioxid Med Sci. 2014; 3(1): 65-72. doi:10.5455/oams.050314.or.059


Web Style

Rawat I, Sharma D, Goel HC. Antioxidant and anti-inflammatory potential of some dietary cucurbits. http://www.ejmoams.com/?mno=47797 [Access: February 20, 2018]. doi:10.5455/oams.050314.or.059


AMA (American Medical Association) Style

Rawat I, Sharma D, Goel HC. Antioxidant and anti-inflammatory potential of some dietary cucurbits. Oxid Antioxid Med Sci. 2014; 3(1): 65-72. doi:10.5455/oams.050314.or.059



Vancouver/ICMJE Style

Rawat I, Sharma D, Goel HC. Antioxidant and anti-inflammatory potential of some dietary cucurbits. Oxid Antioxid Med Sci. (2014), [cited February 20, 2018]; 3(1): 65-72. doi:10.5455/oams.050314.or.059



Harvard Style

Rawat, I., Sharma, D. & Goel, H. C. (2014) Antioxidant and anti-inflammatory potential of some dietary cucurbits. Oxid Antioxid Med Sci, 3 (1), 65-72. doi:10.5455/oams.050314.or.059



Turabian Style

Rawat, Indu, Dhara Sharma, and Harish Chandra Goel. 2014. Antioxidant and anti-inflammatory potential of some dietary cucurbits. Oxidants and Antioxidants in Medical Science, 3 (1), 65-72. doi:10.5455/oams.050314.or.059



Chicago Style

Rawat, Indu, Dhara Sharma, and Harish Chandra Goel. "Antioxidant and anti-inflammatory potential of some dietary cucurbits." Oxidants and Antioxidants in Medical Science 3 (2014), 65-72. doi:10.5455/oams.050314.or.059



MLA (The Modern Language Association) Style

Rawat, Indu, Dhara Sharma, and Harish Chandra Goel. "Antioxidant and anti-inflammatory potential of some dietary cucurbits." Oxidants and Antioxidants in Medical Science 3.1 (2014), 65-72. Print. doi:10.5455/oams.050314.or.059



APA (American Psychological Association) Style

Rawat, I., Sharma, D. & Goel, H. C. (2014) Antioxidant and anti-inflammatory potential of some dietary cucurbits. Oxidants and Antioxidants in Medical Science, 3 (1), 65-72. doi:10.5455/oams.050314.or.059





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