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The role of iNOS in beta cell destruction in diabetes

Nurullah Keklikoglu, Sevtap Akinci.

Cited by (2)

Abstract
Nitric oxide (NO) is a signaling molecule which can play a role in pancreatic pathophysiology and is involved in regulation of beta cell mass. Nitric oxide is produced by the enzyme NO synthase (NOS). Nitric oxide synthase has three major isoforms; one of them, inducible NOS (iNOS) is expressed in almost every cell type. In healthy pancreatic tissues, iNOS immunoreactivity was demonstrated in islet of Langerhans cells, centroacinar cells and ductal cells. In addition, induction of islet iNOS was also demonstrated in acute pancreatitis, and type 1 and type 2 diabetes mellitus. When pancreatic beta cells come up against inflammatory cytokines, lipid stress or hyperglycemia, iNOS activation increases and the resulting high concentrations of NO produced causes cell dysfunction or death and therefore the insulin secretion is inhibited. However, the precise mechanism of iNOS expression and the occurrence of resulting beta-cell damage have not been truly clarified yet. Diabetogenesis cannot be completely prevented with iNOS inhibitors. Physiological and pathological limits of iNOS expression should be established and the mechanism of the damage on beta cells by over-expression should be defined and prevented.

Key words: Beta cells; Diabetes; IDDM; iNOS


 
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How to Cite this Article
Pubmed Style

Keklikoglu N, Akinci S. The role of iNOS in beta cell destruction in diabetes. Oxid Antioxid Med Sci. 2013; 2(4): 251-254. doi:10.5455/oams.081113.rv.010


Web Style

Keklikoglu N, Akinci S. The role of iNOS in beta cell destruction in diabetes. http://www.ejmoams.com/?mno=43096 [Access: August 20, 2018]. doi:10.5455/oams.081113.rv.010


AMA (American Medical Association) Style

Keklikoglu N, Akinci S. The role of iNOS in beta cell destruction in diabetes. Oxid Antioxid Med Sci. 2013; 2(4): 251-254. doi:10.5455/oams.081113.rv.010



Vancouver/ICMJE Style

Keklikoglu N, Akinci S. The role of iNOS in beta cell destruction in diabetes. Oxid Antioxid Med Sci. (2013), [cited August 20, 2018]; 2(4): 251-254. doi:10.5455/oams.081113.rv.010



Harvard Style

Keklikoglu, N. & Akinci, S. (2013) The role of iNOS in beta cell destruction in diabetes. Oxid Antioxid Med Sci, 2 (4), 251-254. doi:10.5455/oams.081113.rv.010



Turabian Style

Keklikoglu, Nurullah, and Sevtap Akinci. 2013. The role of iNOS in beta cell destruction in diabetes. Oxidants and Antioxidants in Medical Science, 2 (4), 251-254. doi:10.5455/oams.081113.rv.010



Chicago Style

Keklikoglu, Nurullah, and Sevtap Akinci. "The role of iNOS in beta cell destruction in diabetes." Oxidants and Antioxidants in Medical Science 2 (2013), 251-254. doi:10.5455/oams.081113.rv.010



MLA (The Modern Language Association) Style

Keklikoglu, Nurullah, and Sevtap Akinci. "The role of iNOS in beta cell destruction in diabetes." Oxidants and Antioxidants in Medical Science 2.4 (2013), 251-254. Print. doi:10.5455/oams.081113.rv.010



APA (American Psychological Association) Style

Keklikoglu, N. & Akinci, S. (2013) The role of iNOS in beta cell destruction in diabetes. Oxidants and Antioxidants in Medical Science, 2 (4), 251-254. doi:10.5455/oams.081113.rv.010





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