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Development of a neuroprotective antioxidant by a mix-and-match strategy

Vijaya B. Kenche, Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, Simon C. Drew.

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Abstract
The compound 4-{[(4-hydroxyphenyl)amino]methyl}-2,6-di-tert-butylphenol (TRS1) was developed using a "mix-and-match" drug design approach for antioxidant-based neuroprotection and therapy. The commonly-used antipyretic drug, paracetamol, which is also found to act as a mild anti-inflammatory, was further modified by attaching a radical scavenger moiety to design a bifunctional bioactive molecule. Using a cell-free 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical reduction assay, and a 2',7'-dichlorofluorescein (DCFH) oxidation assay in cultured N2a mouse neuroblastoma and SH-SY5Y human neuroblastoma cells exposed to oxidative insult (serum deprivation), the radical scavenging ability of TRS1 was found to be comparable with other well-studied antioxidants such as Trolox. The maintenance of antioxidant action of this compound in cells suggests this avenue and other multi-targeted drug discovery paradigms may provide potential therapeutic strategies for targeting complicated neurodegenerative conditions.

Key words: Mix-and-match; Multi-target drug discovery; Neuroprotection; Radical scavenger; Prostaglandin


 
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This Article Cited By the following articles

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1
 
How to Cite this Article
Pubmed Style

Vijaya B. Kenche, Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, Simon C. Drew. Development of a neuroprotective antioxidant by a mix-and-match strategy. Oxid Antioxid Med Sci. 2013; 2(4): 255-264. doi:10.5455/oams.011113.or.055


Web Style

Vijaya B. Kenche, Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, Simon C. Drew. Development of a neuroprotective antioxidant by a mix-and-match strategy. http://www.ejmoams.com/?mno=41704 [Access: November 16, 2018]. doi:10.5455/oams.011113.or.055


AMA (American Medical Association) Style

Vijaya B. Kenche, Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, Simon C. Drew. Development of a neuroprotective antioxidant by a mix-and-match strategy. Oxid Antioxid Med Sci. 2013; 2(4): 255-264. doi:10.5455/oams.011113.or.055



Vancouver/ICMJE Style

Vijaya B. Kenche, Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, Simon C. Drew. Development of a neuroprotective antioxidant by a mix-and-match strategy. Oxid Antioxid Med Sci. (2013), [cited November 16, 2018]; 2(4): 255-264. doi:10.5455/oams.011113.or.055



Harvard Style

Vijaya B. Kenche, Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, Simon C. Drew (2013) Development of a neuroprotective antioxidant by a mix-and-match strategy. Oxid Antioxid Med Sci, 2 (4), 255-264. doi:10.5455/oams.011113.or.055



Turabian Style

Vijaya B. Kenche, Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, Simon C. Drew. 2013. Development of a neuroprotective antioxidant by a mix-and-match strategy. Oxidants and Antioxidants in Medical Science, 2 (4), 255-264. doi:10.5455/oams.011113.or.055



Chicago Style

Vijaya B. Kenche, Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, Simon C. Drew. "Development of a neuroprotective antioxidant by a mix-and-match strategy." Oxidants and Antioxidants in Medical Science 2 (2013), 255-264. doi:10.5455/oams.011113.or.055



MLA (The Modern Language Association) Style

Vijaya B. Kenche, Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, Simon C. Drew. "Development of a neuroprotective antioxidant by a mix-and-match strategy." Oxidants and Antioxidants in Medical Science 2.4 (2013), 255-264. Print. doi:10.5455/oams.011113.or.055



APA (American Psychological Association) Style

Vijaya B. Kenche, Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, Simon C. Drew (2013) Development of a neuroprotective antioxidant by a mix-and-match strategy. Oxidants and Antioxidants in Medical Science, 2 (4), 255-264. doi:10.5455/oams.011113.or.055





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