Oxidants and Antioxidants in Medical Science

2018, Vol: 7, Issue: 1

7/1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to uploaded

Author Statement

« Previous Article

Original Research (Original Article)

Oxid Antioxid Med Sci. 2013; 2(4): 255-264

doi: 10.5455/oams.011113.or.055

Development of a neuroprotective antioxidant by a mix-and-match strategy

Vijaya B. Kenche, Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, Simon C. Drew.

Cited by (1)

Abstract
The compound 4-{[(4-hydroxyphenyl)amino]methyl}-2,6-di-tert-butylphenol (TRS1) was developed using a "mix-and-match" drug design approach for antioxidant-based neuroprotection and therapy. The commonly-used antipyretic drug, paracetamol, which is also found to act as a mild anti-inflammatory, was further modified by attaching a radical scavenger moiety to design a bifunctional bioactive molecule. Using a cell-free 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical reduction assay, and a 2',7'-dichlorofluorescein (DCFH) oxidation assay in cultured N2a mouse neuroblastoma and SH-SY5Y human neuroblastoma cells exposed to oxidative insult (serum deprivation), the radical scavenging ability of TRS1 was found to be comparable with other well-studied antioxidants such as Trolox. The maintenance of antioxidant action of this compound in cells suggests this avenue and other multi-targeted drug discovery paradigms may provide potential therapeutic strategies for targeting complicated neurodegenerative conditions.

Key words: Mix-and-match; Multi-target drug discovery; Neuroprotection; Radical scavenger; Prostaglandin

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	Print this Article
	How to cite this article
	Export to
	Export to
	Related Records
	Articles by Vijaya B. Kenche Articles by Carolin Tumpach Articles by Kevin J. Barnham Articles by Steven J. Collins Articles by Cathryn L. Haigh Articles by Simon C. Drew
	on Google
	on Google Scholar
	Article Statistics
	Viewed: 2172 Downloaded: 605 Cited: 1

REFERENCES

This Article Cited By the following articles

Stable Radical Content and Anti-Radical Activity of Roasted Arabica Coffee: From In-Tact Bean to Coffee Brew PLOS ONE 2015; 10(4): e0122834.	1

How to Cite this Article

Pubmed Style

Kenche VB, Tumpach C, Barnham KJ, Collins SJ, Haigh CL, Drew SC. Development of a neuroprotective antioxidant by a mix-and-match strategy. Oxid Antioxid Med Sci. 2013; 2(4): 255-264. doi:10.5455/oams.011113.or.055

Web Style

Kenche VB, Tumpach C, Barnham KJ, Collins SJ, Haigh CL, Drew SC. Development of a neuroprotective antioxidant by a mix-and-match strategy. http://www.ejmoams.com/?mno=41704 [Access: August 20, 2018]. doi:10.5455/oams.011113.or.055

AMA (American Medical Association) Style

Kenche VB, Tumpach C, Barnham KJ, Collins SJ, Haigh CL, Drew SC. Development of a neuroprotective antioxidant by a mix-and-match strategy. Oxid Antioxid Med Sci. 2013; 2(4): 255-264. doi:10.5455/oams.011113.or.055

Vancouver/ICMJE Style

Kenche VB, Tumpach C, Barnham KJ, Collins SJ, Haigh CL, Drew SC. Development of a neuroprotective antioxidant by a mix-and-match strategy. Oxid Antioxid Med Sci. (2013), [cited August 20, 2018]; 2(4): 255-264. doi:10.5455/oams.011113.or.055

Harvard Style

Kenche, V. B., Tumpach, C., Barnham, K. J., Collins, S. J., Haigh, C. L. & Drew, S. C. (2013) Development of a neuroprotective antioxidant by a mix-and-match strategy. Oxid Antioxid Med Sci, 2 (4), 255-264. doi:10.5455/oams.011113.or.055

Turabian Style

Kenche, Vijaya B., Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, and Simon C. Drew. 2013. Development of a neuroprotective antioxidant by a mix-and-match strategy. Oxidants and Antioxidants in Medical Science, 2 (4), 255-264. doi:10.5455/oams.011113.or.055

Chicago Style

Kenche, Vijaya B., Carolin Tumpach, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, and Simon C. Drew. "Development of a neuroprotective antioxidant by a mix-and-match strategy." Oxidants and Antioxidants in Medical Science 2 (2013), 255-264. doi:10.5455/oams.011113.or.055

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Kenche, V. B., Tumpach, C., Barnham, K. J., Collins, S. J., Haigh, C. L. & Drew, S. C. (2013) Development of a neuroprotective antioxidant by a mix-and-match strategy. Oxidants and Antioxidants in Medical Science, 2 (4), 255-264. doi:10.5455/oams.011113.or.055

Contact Information

Your comments are very important to us

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access. The articles in Oxidants and Antioxidants in Medical Science are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

Copyright � 2018 Oxidants and Antioxidants in Medical Science All Rights Reserved. Subject to change without notice from or liability to Oxidants and Antioxidants in Medical Science. For best results, please use Internet Explorer or Google Chrome	Contact Information Your comments are very important to us We welcome your ideas, suggestions, comments, or questions. To reach Editorial Board please use one of the methods provided below. Call us at (302) 355 0333. Our office hours are Monday - Friday, 8 AM to 5 PM EST. Or e-mail us at info@ejmanager.com We will respond within 48 to 72 hours. Change of address or personal information? Please visit your account at www.ejmanager.com to update your information.