ISSN 2146-8389
 

Original Research (Original Article) 


Correlation of cobalt binding activity of albumin with the common markers of oxidative stress in thalassemia syndrome patients

Angshuman De, Neepa Chowdhury, Pradyot Kumar Sen, Indranil Chakraborty, Prantar Chakraborty, Kaushik Bhowmick.

Cited by (1)

Abstract
Scanty evidence exists for change in cobalt binding activity of albumin in Thalassemia. The aim of the present study was to observe whether cobalt binding activity of albumin would be altered in thalassemia patients receiving chronic transfusion and also whether the same would be correlated with oxidative stress markers. The present hospital-based, non-interventional, cross-sectional case control study was undertaken in Medical College and Hospital, Kolkata, India. Sixty patients with thalassemia syndrome requiring blood or erythrocyte transfusion for more than five years were randomly selected as cases. Age and sex matched controls were selected from apparently healthy individuals who were neither thalassemic trait nor carrier. Cobalt binding activity of albumin (ACB), thiobarbituric acid reactive substances (TBARS), protein carbonyls, protein bound sialic acid/sialoprotein ratio were measured in serum samples. There was no significant difference in cobalt binding activity between case and control. Serum protein carbonyls and TBARS were significantly higher in case population compared to control group. Ratio of serum protein bound sialic acid to serum mucoprotein was significantly lower in thalassemia cases. The study demonstrated that ACB was not correlated with serum TBARS, serum protein carbonyls as well as protein bound sialic acid/sialoprotein ratio in thalassemia. In conclusion, ACB is not superior to other markers of oxidative stress in identifying oxidative stress in thalassemia patients receiving repeated transfusions.

Key words: Albumin; Cobalt binding; Protein carbonylation; Thalassemia syndrome; Sialic acid; Sialoprotein


 
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This Article Cited By the following articles

Ischemia-modified albumin as a marker of vascular dysfunction and subclinical atherosclerosis in β-thalassemia major
Redox Report 2017; (): 1.

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How to Cite this Article
Pubmed Style

De A, Chowdhury N, Sen PK, Chakraborty I, Chakraborty P, Bhowmick K. Correlation of cobalt binding activity of albumin with the common markers of oxidative stress in thalassemia syndrome patients. Oxid Antioxid Med Sci. 2013; 2(4): 297-301. doi:10.5455/oams.151013.or.054


Web Style

De A, Chowdhury N, Sen PK, Chakraborty I, Chakraborty P, Bhowmick K. Correlation of cobalt binding activity of albumin with the common markers of oxidative stress in thalassemia syndrome patients. http://www.ejmoams.com/?mno=40918 [Access: August 18, 2018]. doi:10.5455/oams.151013.or.054


AMA (American Medical Association) Style

De A, Chowdhury N, Sen PK, Chakraborty I, Chakraborty P, Bhowmick K. Correlation of cobalt binding activity of albumin with the common markers of oxidative stress in thalassemia syndrome patients. Oxid Antioxid Med Sci. 2013; 2(4): 297-301. doi:10.5455/oams.151013.or.054



Vancouver/ICMJE Style

De A, Chowdhury N, Sen PK, Chakraborty I, Chakraborty P, Bhowmick K. Correlation of cobalt binding activity of albumin with the common markers of oxidative stress in thalassemia syndrome patients. Oxid Antioxid Med Sci. (2013), [cited August 18, 2018]; 2(4): 297-301. doi:10.5455/oams.151013.or.054



Harvard Style

De, A., Chowdhury, N., Sen, P. K., Chakraborty, I., Chakraborty, P. & Bhowmick, K. (2013) Correlation of cobalt binding activity of albumin with the common markers of oxidative stress in thalassemia syndrome patients. Oxid Antioxid Med Sci, 2 (4), 297-301. doi:10.5455/oams.151013.or.054



Turabian Style

De, Angshuman, Neepa Chowdhury, Pradyot Kumar Sen, Indranil Chakraborty, Prantar Chakraborty, and Kaushik Bhowmick. 2013. Correlation of cobalt binding activity of albumin with the common markers of oxidative stress in thalassemia syndrome patients. Oxidants and Antioxidants in Medical Science, 2 (4), 297-301. doi:10.5455/oams.151013.or.054



Chicago Style

De, Angshuman, Neepa Chowdhury, Pradyot Kumar Sen, Indranil Chakraborty, Prantar Chakraborty, and Kaushik Bhowmick. "Correlation of cobalt binding activity of albumin with the common markers of oxidative stress in thalassemia syndrome patients." Oxidants and Antioxidants in Medical Science 2 (2013), 297-301. doi:10.5455/oams.151013.or.054



MLA (The Modern Language Association) Style

De, Angshuman, Neepa Chowdhury, Pradyot Kumar Sen, Indranil Chakraborty, Prantar Chakraborty, and Kaushik Bhowmick. "Correlation of cobalt binding activity of albumin with the common markers of oxidative stress in thalassemia syndrome patients." Oxidants and Antioxidants in Medical Science 2.4 (2013), 297-301. Print. doi:10.5455/oams.151013.or.054



APA (American Psychological Association) Style

De, A., Chowdhury, N., Sen, P. K., Chakraborty, I., Chakraborty, P. & Bhowmick, K. (2013) Correlation of cobalt binding activity of albumin with the common markers of oxidative stress in thalassemia syndrome patients. Oxidants and Antioxidants in Medical Science, 2 (4), 297-301. doi:10.5455/oams.151013.or.054





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