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Study of Mentha piperita against gamma radiation in mice

Pallavi Kaushik, Megha Mathur, Neha Rawat, Tanushree Saxena, Sanjoli Mobar, Punar Dutt Meena.

Cited by (1)

Abstract
The aim of this study is to analyze the potential hepatoprotective efficacy of alcoholic extract of Mentha piperita (Linn) against radiation-induced liver injury in Swiss albino mice after whole body irradiation in terms of histopathological lesions and levels of lipid peroxidation and reduced glutathione in liver tissue. M.piperita leaves were extracted in 50% ethanol and administered at the dose of 100 mg/kg b.wt/day for three consecutive days before whole body irradiation (6, 8 and 10 Gy). The extract provided significant hepatoprotection against different doses of radiation in terms of higher number of normal hepatocyte count, lower abnormal hepatocyte count and lower binucleated cell population along with other radiolesions as compared to irradiation alone group. The optimum dose of 100 mg/kg b.wt/day for three consecutive days also arrested decline in the level of reduced glutathione and elevation in lipid peroxidation significantly at autopsy intervals of 1, 3, 7, 14 and 30 days post-irradiation (6 and 8 Gy). The results of this study confirmed the hepatoprotective potential of M.piperita leaves alcoholic extract in controlling the development of radiolesions and number of abnormal hepatocytes in liver. This protection can be attributed to the antioxidant and antiperoxidant properties of Mentha piperita.

Key words: Hepatoprotective; Lipid Peroxidation; Mentha piperita; Radiolesions; Reduced Glutathione


 
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How to Cite this Article
Pubmed Style

Pallavi Kaushik, Megha Mathur, Neha Rawat, Tanushree Saxena, Sanjoli Mobar, Punar Dutt Meena. Study of Mentha piperita against gamma radiation in mice. Oxid Antioxid Med Sci. 2013; 2(4): 285-295. doi:10.5455/oams.190713.or.050


Web Style

Pallavi Kaushik, Megha Mathur, Neha Rawat, Tanushree Saxena, Sanjoli Mobar, Punar Dutt Meena. Study of Mentha piperita against gamma radiation in mice. http://www.ejmoams.com/?mno=38251 [Access: November 16, 2018]. doi:10.5455/oams.190713.or.050


AMA (American Medical Association) Style

Pallavi Kaushik, Megha Mathur, Neha Rawat, Tanushree Saxena, Sanjoli Mobar, Punar Dutt Meena. Study of Mentha piperita against gamma radiation in mice. Oxid Antioxid Med Sci. 2013; 2(4): 285-295. doi:10.5455/oams.190713.or.050



Vancouver/ICMJE Style

Pallavi Kaushik, Megha Mathur, Neha Rawat, Tanushree Saxena, Sanjoli Mobar, Punar Dutt Meena. Study of Mentha piperita against gamma radiation in mice. Oxid Antioxid Med Sci. (2013), [cited November 16, 2018]; 2(4): 285-295. doi:10.5455/oams.190713.or.050



Harvard Style

Pallavi Kaushik, Megha Mathur, Neha Rawat, Tanushree Saxena, Sanjoli Mobar, Punar Dutt Meena (2013) Study of Mentha piperita against gamma radiation in mice. Oxid Antioxid Med Sci, 2 (4), 285-295. doi:10.5455/oams.190713.or.050



Turabian Style

Pallavi Kaushik, Megha Mathur, Neha Rawat, Tanushree Saxena, Sanjoli Mobar, Punar Dutt Meena. 2013. Study of Mentha piperita against gamma radiation in mice. Oxidants and Antioxidants in Medical Science, 2 (4), 285-295. doi:10.5455/oams.190713.or.050



Chicago Style

Pallavi Kaushik, Megha Mathur, Neha Rawat, Tanushree Saxena, Sanjoli Mobar, Punar Dutt Meena. "Study of Mentha piperita against gamma radiation in mice." Oxidants and Antioxidants in Medical Science 2 (2013), 285-295. doi:10.5455/oams.190713.or.050



MLA (The Modern Language Association) Style

Pallavi Kaushik, Megha Mathur, Neha Rawat, Tanushree Saxena, Sanjoli Mobar, Punar Dutt Meena. "Study of Mentha piperita against gamma radiation in mice." Oxidants and Antioxidants in Medical Science 2.4 (2013), 285-295. Print. doi:10.5455/oams.190713.or.050



APA (American Psychological Association) Style

Pallavi Kaushik, Megha Mathur, Neha Rawat, Tanushree Saxena, Sanjoli Mobar, Punar Dutt Meena (2013) Study of Mentha piperita against gamma radiation in mice. Oxidants and Antioxidants in Medical Science, 2 (4), 285-295. doi:10.5455/oams.190713.or.050





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