ISSN 2146-8389
 

Hypothesis 


A new method for the activation of the cellular antioxidant system

Velio A. Bocci.

Cited by (2)

Abstract
The result that pharmacological ascorbic acid concentration in blood releases hydrogen peroxide and ascorbyl radicals when ascorbic acid is transferred into interstitial fluids is reviewed. The hydrogen peroxide concentration in some interstitial fluids (liver, gut, pancreas, kidneys) may be responsible for some killing activity of neoplastic cells deprived of antioxidant defences. However a real anti-tumour effect limited to some neoplasms remains an open problem not explored here. On the other hand reactive oxygen species (ROS) may induce peroxidation of lipids and, in this case, peroxidation compounds and alkenals returning into the general circulation may represent a moderate oxidative stress able to activate and free nuclear related factor 2 (Nrf2), which, after binding to antioxidant response elements (ARE), switch on the upregulation of the innate antioxidant system. This situation can be achieved by repeated intravenous infusion of ascorbic acid at the dose of 0.36-0.64 g/kg in patients with chronic cardiovascular diseases, macular degeneration (dry form), type 2 diabetes and chronic infectious diseases where, in spite of effective orthodox drugs, the diseases are complicated by a chronic oxidative stress. Consequently a prolonged orthodox therapy integrated by repeated ascorbic acid infusions may lead to a real improvement due to the combined approach proposed in this paper.

Key words: Alkenals; Antioxidant response elements; Ascorbic acid; Hydrogen peroxide; Integrative medicine; Reactive oxygen species


 
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How to Cite this Article
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Velio A. Bocci. A new method for the activation of the cellular antioxidant system. Oxid Antioxid Med Sci. 2013; 2(3): 149-154. doi:10.5455/oams.130513.hp.001


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Velio A. Bocci. A new method for the activation of the cellular antioxidant system. http://www.ejmoams.com/?mno=36333 [Access: November 16, 2018]. doi:10.5455/oams.130513.hp.001


AMA (American Medical Association) Style

Velio A. Bocci. A new method for the activation of the cellular antioxidant system. Oxid Antioxid Med Sci. 2013; 2(3): 149-154. doi:10.5455/oams.130513.hp.001



Vancouver/ICMJE Style

Velio A. Bocci. A new method for the activation of the cellular antioxidant system. Oxid Antioxid Med Sci. (2013), [cited November 16, 2018]; 2(3): 149-154. doi:10.5455/oams.130513.hp.001



Harvard Style

Velio A. Bocci (2013) A new method for the activation of the cellular antioxidant system. Oxid Antioxid Med Sci, 2 (3), 149-154. doi:10.5455/oams.130513.hp.001



Turabian Style

Velio A. Bocci. 2013. A new method for the activation of the cellular antioxidant system. Oxidants and Antioxidants in Medical Science, 2 (3), 149-154. doi:10.5455/oams.130513.hp.001



Chicago Style

Velio A. Bocci. "A new method for the activation of the cellular antioxidant system." Oxidants and Antioxidants in Medical Science 2 (2013), 149-154. doi:10.5455/oams.130513.hp.001



MLA (The Modern Language Association) Style

Velio A. Bocci. "A new method for the activation of the cellular antioxidant system." Oxidants and Antioxidants in Medical Science 2.3 (2013), 149-154. Print. doi:10.5455/oams.130513.hp.001



APA (American Psychological Association) Style

Velio A. Bocci (2013) A new method for the activation of the cellular antioxidant system. Oxidants and Antioxidants in Medical Science, 2 (3), 149-154. doi:10.5455/oams.130513.hp.001





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