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Beneficial effect of lipoic acid on nicotine-induced vascular endothelial damage in rabbits

Marwa S. Zaghloul, Manar A. Nader, Hassan El-Kashef, Nariman M. Gamiel.

Cited by (2)

Abstract
This study has been designed to investigate the effect of alpha lipoic acid (ALA) in nicotine-induced vascular endothelial dysfunction (VED) in rabbits. Nicotine (7.5 mg/kg/day, sc, 6 weeks) was administered to produce VED in rabbits. The development of VED was assessed by employing aortic histopathology and estimating serum concentration of nitrite/nitrate (NOx). Further, serum lipid profile was assessed. Moreover, the oxidative stress was assessed by estimating serum thiobarbituric acid reactive substances (TBARS) reduced glutathione (GSH) and superoxide dismutase (SOD) generation. The administration of nicotine produced VED by impairing the integrity of vascular endothelium and subsequently decreasing serum concentration of NOx. Further, nicotine produced oxidative stress, which was assessed in terms of increase in serum TBARS and decreased GSH and SOD levels. However, treatment with ALA (20 mg/kg/day, orally) markedly prevented nicotine-induced VED and oxidative stress by improving the integrity of vascular endothelium, increasing the concentration of serum NOx, decreasing serum TBARS and normalizing SOD and GSH activities. Thus, it may be concluded that ALA reduces the oxidative stress and consequently improves the integrity of vascular endothelium and enhances the generation of nitric oxide to prevent nicotine-induced experimental VED.

Key words: Alpha lipoic acid; Endothelial damage; Nicotine; Nitric oxide; Vascular damage


 
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REFERENCES
1.Balakumar P, Kaur T, Singh M. Potential target sites to modulate vascular endothelial dysfunction: Current perspectives and future directions. Toxicology 2008; 245:49-64.

http://dx.doi.org/10.1016/j.tox.2007.12.011

[Pubmed]   


2.De Vriese AS, Verbeuren TJ, de Voorde JV, Lameire NH, Vanhoutte PM. Endothelial dysfunction in diabetes. Br J Pharmacol 2000; 130:963-74.

http://dx.doi.org/10.1038/sj.bjp.0703393

[
Pubmed]    [PMC Free Fulltext]   


3.Kawashima S, Yokoyama M. Dysfunction of endothelial nitric oxide synthase and atherosclerosis. Arterioscler Thromb Vasc Biol 2004; 24:998-1005.

http://dx.doi.org/10.1161/01.ATV.0000125114.88079.96

[
Pubmed]   


4.Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress. Circ Res 2000; 87:840-4.

http://dx.doi.org/10.1161/01.RES.87.10.840


5.Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004; 109:III27–32.

http://dx.doi.org/10.1161/01.CIR.0000131515.03336.f8

[
Pubmed]   


6.Savoia C, Schiffrin EL. Vascular inflammation in hypertension and diabetes: Molecular mechanisms and therapeutic interventions. Clin Sci 2007; 112:375-84.

http://dx.doi.org/10.1042/CS20060247

[
Pubmed]   


7.Desjardins F, Balligand JL. Nitric oxide-dependent endothelial function and cardiovascular disease. Acta Clinica Belgica 2006; 61:326-34.

[
Pubmed]   


8.Gullu H, Caliskan M, Ciftci O, Erdogan D, Topcu S, Yildirim E. Light cigarette smoking impairs coronarymicrovascular functions as severely as smoking regular cigarettes. Heart 2007; 93:1274-7.

http://dx.doi.org/10.1136/hrt.2006.100255

[
Pubmed]    [PMC Free Fulltext]   


9.Chakkarwar VA. Fenofibrate attenuates nicotine-induced vascular endothelial dysfunction in the rat. Vascul Pharmacol 2011; 55:163-8.

http://dx.doi.org/10.1016/j.vph.2011.08.215

[
Pubmed]   


10.Neunteufl T, Heher S, Kostner K, Mitulovic G, Lehr S, Khoschsorur. Contribution of nicotine to acute endothelial dysfunction in long-term smokers. J Am Coll Cardiol 2002; 39:251-6.

http://dx.doi.org/10.1016/S0735-1097(01)01732-6


11.Tanus-Santos JE, Toledo JC, Cittadino M, Sabha M, Rocha JC, Moreno H Jr. Cardiovascular effects of transdermal nicotine in mildly hypertensive smokers. Am J Hypertens 2001; 14:610-4.

http://dx.doi.org/10.1016/S0895-7061(01)01301-2

[
Pubmed]   


12.Ashakumary L, Vijayammal PL. Effect of nicotine on antioxidant defence mechanisms in rats fed a high-fat diet. Pharmacology 1996; 52:153-8.

http://dx.doi.org/10.1159/000139379

[
Pubmed]   


13.Cirillo P, DE Rosa S, Pacileo M, Gargiulo A, Leonardi A, Angri V, Formisano S, Chiariello M. Nicotine induces tissue factor expression in cultured endothelial and smooth muscle cells. J Thromb Haemost 2006; 4:453-8.

http://dx.doi.org/10.1111/j.1538-7836.2006.01741.x

[
Pubmed]   


14.Cirillo P, Pacileo M, De Rosa S, Calabro P, Gargiulo A, Angri V, Prevete N, Fiorentino I, Ucci G, Sasso L, Petrillo G, Musto D'Amore S, Chiariello M. HMG-CoA reductase inhibitors reduce nicotine-induced expression of cellular adhesion molecules in cultured human coronary endothelial cells. J Vasc Res 2007; 44:460-70.

http://dx.doi.org/10.1159/000106464

[
Pubmed]   


15.Arivazhagan P, Panneerselvam C. Effect of DL-α-lipoic acid on neural antioxidants in aged rats. Pharm Res 2002; 42:219-22.

http://dx.doi.org/10.1006/phrs.2000.0679

[
Pubmed]   


16.Pari L, Latha M: Antidiabetic effect of Scoparia dulcis: effect on lipid peroxidation in streptozotocin diabetes. Gen Physiol Biophys 2005; 24:13-26.

[
Pubmed]   


17.Erik JH. Exercise training and the antioxidant α-lipoic acid in the treatment of insulin resistance and type 2 diabetes. Free Radic Biol Med 2006; 40:3-12.

http://dx.doi.org/10.1016/j.freeradbiomed.2005.04.002

[
Pubmed]   


18.Marangon K, Devaraj S, Tirosh O, Packer L, Jialal I. Comparison of the effect of alpha-lipoic acid and alphatocopherol supplementation on measures of oxidative stress. Free Radic Biol Med 1999; 27:1114–21.

http://dx.doi.org/10.1016/S0891-5849(99)00155-0

[
Pubmed]   


19.Susan AM, Paul BL, Betty KP, Glenda CG, Jeff S, Coombes JS. Bcl-2 in endothelial cells is increased by vitamin E and α-lipoic acid supplementation but not exercise training. J Mol Cell Cardiol 2005; 38:445-51.

http://dx.doi.org/10.1016/j.yjmcc.2004.11.026

[
Pubmed]   


20.Perricone N, Nagy K, Horvath F, Dajko G, Uray I, Zs-Nagy I. Alpha lipoic acid (ALA) protects proteins against the hydroxyl free radical-induced alterations: rationale for its geriatric topical application. Arch Gerontol Geriatr 1999, 29:45-56.

http://dx.doi.org/10.1016/S0167-4943(99)00022-9

[
Pubmed]   


21.Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem 1974; 20:470-5.

[
Pubmed]   


22.Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifugation. Clin Chem 1972; 18:499-500.

[
Pubmed]   


23.Balakumar P, Sharma R, Singh M. Benfotiamine attenuates nicotine and uric acid-induced vascular endothelial dysfunction in rats. Pharmacol Res 2008; 58: 356-63.

http://dx.doi.org/10.1016/j.phrs.2008.09.012

[
Pubmed]   


24.Balakumar P, Chakkarwar VA, Singh M. Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat. Mol Cell Biochem 2009; 320:149-62.

http://dx.doi.org/10.1007/s11010-008-9917-z

[
Pubmed]   


25.Marklund SL. Superoxide dismutase isoenzymes in tissues and plasma from New Zealand black mice, nude mice and normal BALB/c mice. Mutat Res 1985; 148:129-34.

http://dx.doi.org/10.1016/0027-5107(85)90216-7

[
Pubmed]   


26.Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959; 82:70-7.

http://dx.doi.org/10.1016/0003-9861(59)90090-6

[
Pubmed]   


27.Benowitz NL, Gourlay SG. Cardiovascular toxicity of nicotine: Implications for nicotine replacement therapy. J Am Coll Cardiol 1997; 29:1422-31.

http://dx.doi.org/10.1016/S0735-1097(97)00079-X

[
Pubmed]   


28.Ambrose JA, Barua RS. The pathophysiology of cigarette smoking and cardiovascular disease an update. J Am Coll Cardiol 2004 ; 43: 1731-7.

http://dx.doi.org/10.1016/j.jacc.2003.12.047

[
Pubmed]   


29.Fang Q, Sun H, Arrick DM, Mayhan WG. Inhibition of NADPH oxidase improves impaired reactivity of pial arterioles during chronic exposure to nicotine. J Appl Physiol 2006; 100:631-6.

http://dx.doi.org/10.1152/japplphysiol.00975.2005

[
Pubmed]   


30.Wang Y, Wang Z, Zhou Y, Liu L, Zhao Y, Yao C, Wang L, Qiao Z. Nicotine stimulates adhesion molecular expression via calcium influx and mitogen-activated protein kinases in human endothelial cells. Int J Biochem Cell Biol 2006; 38:170-82.

[
Pubmed]   


31.Glantz SA, Parmley WW. Passive and active smoking. A problem for adults. Circulation 1996; 94:596-8.

http://dx.doi.org/10.1161/01.CIR.94.4.596

[
Pubmed]   


32.Giannattasio C, Zoppo A, Gentile G, Failla M, Capra A, Maggi FM. Acute effects of high fat meal on endothelial dysfunction in moderately dyslipidemic subjects. Arterioscler Thromb Vasc Biol 2005; 25:406-10.

http://dx.doi.org/10.1161/01.ATV.0000152231.93590.17

[
Pubmed]   


33.Shah DI, Singh M. Effect of bis (maltolato) oxovanadium on experimental vascular endothelial dysfunction. Naunyn Schmiedebergs Arch Pharmacol 2006; 373:221-9.

http://dx.doi.org/10.1007/s00210-006-0066-1

[
Pubmed]   


34.Chattopadhyay K, Chattopadhyay BD. Effect of nicotine on lipid profile, peroxidation & antioxidant enzymes in female rats with restricted dietary protein. Indian J Med Res 2008; 127:571-6.

[
Pubmed]   


35.Tomonaga I, Jingyan L, Shuji K, Tomonari K, Xiaofei W, Huijun S, Masatoshi M, Hisataka S, Teruo W, Nobuhiro Y, Jianglin F. Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits. Atherosclerosis 2005; 179:87-95.

http://dx.doi.org/10.1016/j.atherosclerosis.2004.10.044

[
Pubmed]   


36.Chiba T, Miura S, Sawamura F, Uetsuka R, Tomita I, Inoue Y, Tsutsumi K, Tomita T. Antiatherogenic effects of a novel lipoprotein lipase-enhancing agent in cholesterol-fed New Zealand white rabbits. Arterioscler Thromb Vasc Biol 1997; 7:2601-8.

http://dx.doi.org/10.1161/01.ATV.17.11.2601

[
Pubmed]   


37.Lee WJ, Lee IK, Kim HS, Kim YM, Koh EH, Won JC, Han SM, Kim MS, Jo I, Oh GT, Park IS, Youn JH, Park SW, Lee KU, Park JY. Alpha-Lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler Thromb Vasc Biol 2005; 25:2488-94.

http://dx.doi.org/10.1161/01.ATV.0000190667.33224.4c

[
Pubmed]   


38.Anter E, Thomas SR, Schulz E, Shapira OM, Vita JA, Keaney JF Jr. Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols. J Biol Chem 2004; 279:46637-43

http://dx.doi.org/10.1074/jbc.M405547200

[
Pubmed]   


39.Stalker TJ, Skvarka CB, Scalia R. A novel role for calpains in the endothelial dysfunction of hyperglycemia. FASEB J 2003; 17:1511-3.

[
Pubmed]   


40.Zhang WJ, Wei H, Hagen T, Frei B. Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Proc Natl Acad Sci USA 2007; 104:4077-82.

http://dx.doi.org/10.1073/pnas.0700305104

[
Pubmed]    [PMC Free Fulltext]   


41.Zhang WJ, Bird KE, McMillen TS, LeBoeuf RC, Hagen TM, Frei B. Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. Circulation 2008; 117:421-8

http://dx.doi.org/10.1161/CIRCULATIONAHA.107.725275

[
Pubmed]   


42.Packer L, Witt EH, Tritchler HJ. Alpha lipoic acid as a biological antioxidant. Free Radic Biol Med 1995; 19:227-50.

http://dx.doi.org/10.1016/0891-5849(95)00017-R

[
Pubmed]   


43.Packer L, Colman C. The Antioxidant Miracle. John Wiley & Sons, New York, NY, USA, pp 45-80, 1999.


44.Packer L, Tritchler HJ, Wessel L. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med 1996; 22:359-78.

http://dx.doi.org/10.1016/S0891-5849(96)00269-9

[
Pubmed]   


45.Kim MY, Kim EJ, Kim YN, Choi C, Lee BH. Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats. Nutr Res Pract 2011; 5:421-8.

http://dx.doi.org/10.4162/nrp.2011.5.5.421

[
Pubmed]    [PMC Free Fulltext]   


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How to Cite this Article
Pubmed Style

Zaghloul MS, Nader MA, El-Kashef H, Gamiel NM. Beneficial effect of lipoic acid on nicotine-induced vascular endothelial damage in rabbits. Oxid Antioxid Med Sci. 2013; 2(3): 175-180. doi:10.5455/oams.090613.or.045


Web Style

Zaghloul MS, Nader MA, El-Kashef H, Gamiel NM. Beneficial effect of lipoic acid on nicotine-induced vascular endothelial damage in rabbits. http://www.ejmoams.com/?mno=36296 [Access: May 22, 2018]. doi:10.5455/oams.090613.or.045


AMA (American Medical Association) Style

Zaghloul MS, Nader MA, El-Kashef H, Gamiel NM. Beneficial effect of lipoic acid on nicotine-induced vascular endothelial damage in rabbits. Oxid Antioxid Med Sci. 2013; 2(3): 175-180. doi:10.5455/oams.090613.or.045



Vancouver/ICMJE Style

Zaghloul MS, Nader MA, El-Kashef H, Gamiel NM. Beneficial effect of lipoic acid on nicotine-induced vascular endothelial damage in rabbits. Oxid Antioxid Med Sci. (2013), [cited May 22, 2018]; 2(3): 175-180. doi:10.5455/oams.090613.or.045



Harvard Style

Zaghloul, M. S., Nader, M. A., El-Kashef, H. & Gamiel, N. M. (2013) Beneficial effect of lipoic acid on nicotine-induced vascular endothelial damage in rabbits. Oxid Antioxid Med Sci, 2 (3), 175-180. doi:10.5455/oams.090613.or.045



Turabian Style

Zaghloul, Marwa S., Manar A. Nader, Hassan El-Kashef, and Nariman M. Gamiel. 2013. Beneficial effect of lipoic acid on nicotine-induced vascular endothelial damage in rabbits. Oxidants and Antioxidants in Medical Science, 2 (3), 175-180. doi:10.5455/oams.090613.or.045



Chicago Style

Zaghloul, Marwa S., Manar A. Nader, Hassan El-Kashef, and Nariman M. Gamiel. "Beneficial effect of lipoic acid on nicotine-induced vascular endothelial damage in rabbits." Oxidants and Antioxidants in Medical Science 2 (2013), 175-180. doi:10.5455/oams.090613.or.045



MLA (The Modern Language Association) Style

Zaghloul, Marwa S., Manar A. Nader, Hassan El-Kashef, and Nariman M. Gamiel. "Beneficial effect of lipoic acid on nicotine-induced vascular endothelial damage in rabbits." Oxidants and Antioxidants in Medical Science 2.3 (2013), 175-180. Print. doi:10.5455/oams.090613.or.045



APA (American Psychological Association) Style

Zaghloul, M. S., Nader, M. A., El-Kashef, H. & Gamiel, N. M. (2013) Beneficial effect of lipoic acid on nicotine-induced vascular endothelial damage in rabbits. Oxidants and Antioxidants in Medical Science, 2 (3), 175-180. doi:10.5455/oams.090613.or.045





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