ISSN 2146-8389
 

Review Article 


Significance of the nitrosative-oxidative stress disequilibrium on endothelial dysfunction during cardiac development

Maqsood M. Elahi, Bashir M. Matata.

Abstract
Endothelial dysfunction as a consequence of a variety of common cardiovascular disease risk factors is thought to be associated with increased reactive oxygen species (ROS) and the subsequent decrease in vascular bioavailability of nitric oxide (NO). In this article we give a detailed discussion of evidence of the impact of oxidative-nitrosative stress during maternal pregnancy on fetal development in animal models and also the association with the onset of cardiovascular conditions in adult humans. We highlighted specifically the presence of ROS in circulating blood as the key intermediary related to vascular injury and organ dysfunction, the evidence that red blood cells regulate the arteriolar microcirculation, coupling oxygen delivery with blood flow, and highlighting their role in NO bioavailability. The unique nature of relationship between cell-signalling, transcriptional mechanisms and oxidative-nitrosative stress in the progression of coronary heart disease has also been discussed in greater detail. We have also discussed the emerging concepts that pharmacological prevention of cardiovascular events in the future might consists of the control of classical risk factors with specific interventions targeting oxidative stress while simultaneously improving NO production.

Key words: Cardiac development; Developmental programming; Oxidative stress


 
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PMid:8800132

How to Cite this Article
Pubmed Style

Elahi MM, Matata BM. Significance of the nitrosative-oxidative stress disequilibrium on endothelial dysfunction during cardiac development. Oxid Antioxid Med Sci. 2013; 2(2): 73-82. doi:10.5455/oams.070413.rv.006


Web Style

Elahi MM, Matata BM. Significance of the nitrosative-oxidative stress disequilibrium on endothelial dysfunction during cardiac development. http://www.ejmoams.com/?mno=34775 [Access: May 22, 2018]. doi:10.5455/oams.070413.rv.006


AMA (American Medical Association) Style

Elahi MM, Matata BM. Significance of the nitrosative-oxidative stress disequilibrium on endothelial dysfunction during cardiac development. Oxid Antioxid Med Sci. 2013; 2(2): 73-82. doi:10.5455/oams.070413.rv.006



Vancouver/ICMJE Style

Elahi MM, Matata BM. Significance of the nitrosative-oxidative stress disequilibrium on endothelial dysfunction during cardiac development. Oxid Antioxid Med Sci. (2013), [cited May 22, 2018]; 2(2): 73-82. doi:10.5455/oams.070413.rv.006



Harvard Style

Elahi, M. M. & Matata, B. M. (2013) Significance of the nitrosative-oxidative stress disequilibrium on endothelial dysfunction during cardiac development. Oxid Antioxid Med Sci, 2 (2), 73-82. doi:10.5455/oams.070413.rv.006



Turabian Style

Elahi, Maqsood M., and Bashir M. Matata. 2013. Significance of the nitrosative-oxidative stress disequilibrium on endothelial dysfunction during cardiac development. Oxidants and Antioxidants in Medical Science, 2 (2), 73-82. doi:10.5455/oams.070413.rv.006



Chicago Style

Elahi, Maqsood M., and Bashir M. Matata. "Significance of the nitrosative-oxidative stress disequilibrium on endothelial dysfunction during cardiac development." Oxidants and Antioxidants in Medical Science 2 (2013), 73-82. doi:10.5455/oams.070413.rv.006



MLA (The Modern Language Association) Style

Elahi, Maqsood M., and Bashir M. Matata. "Significance of the nitrosative-oxidative stress disequilibrium on endothelial dysfunction during cardiac development." Oxidants and Antioxidants in Medical Science 2.2 (2013), 73-82. Print. doi:10.5455/oams.070413.rv.006



APA (American Psychological Association) Style

Elahi, M. M. & Matata, B. M. (2013) Significance of the nitrosative-oxidative stress disequilibrium on endothelial dysfunction during cardiac development. Oxidants and Antioxidants in Medical Science, 2 (2), 73-82. doi:10.5455/oams.070413.rv.006





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