ISSN 2146-8389
 

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Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines

Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty.

Cited by (11)

Abstract
This research was conducted to identify the anticancer and antioxidant activity of Catharanthus roseus [L] G.Don, Dendrophtoe petandra L, Piper betle L and Curcuma mangga Val aqueous extracts in T47D human ductal breast epithelial tumor cell line. The anticancer potency was determined via the MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay while the apoptotic activity was determined with Sub-G1 flow cytometric analysis. The antioxidant activity was determined by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. C.roseus was able to reduce T47D cell proliferation with a median inhibition concentration (IC50) of 2.8%; D.petandra 1.2%; P.betle 2.8%; and C.mangga 74.8%. The apoptotic analysis result showed that C.roseus induced apoptosis for 37.67%; D.petandra 24.03%; P.betle 9.45%; and C.mangga 0.41%. Meanwhile doxorubicin at 10 Ī¼g/ml induced apoptosis for 36.06%. The highest DPPH scavenging activity was recorded for P.betle extract as to be 83%; D.petandra 75.11%; C.roseus 71.87%; and the lowest for C.mangga as 38.45%. C.moseus and D.petandra aqueous extracts presented the highest anticancer activity by means of cell proliferation inhibition and inducing apoptosis. P.betle extract represented the strongest antioxidant activity. C.mangga extract exhibited no anticancer and only low antioxidant activity.

Key words: Anticancer; Apoptosis; Catharanthus roseus; Curcuma mangga; Dendrophtoe petandra; Piper betle; T47D cell line


 
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How to Cite this Article
Pubmed Style

Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty. Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines. Oxid Antioxid Med Sci. 2013; 2(2): 137-142. doi:10.5455/oams.100413.or.038


Web Style

Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty. Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines. http://www.ejmoams.com/?mno=34421 [Access: December 19, 2018]. doi:10.5455/oams.100413.or.038


AMA (American Medical Association) Style

Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty. Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines. Oxid Antioxid Med Sci. 2013; 2(2): 137-142. doi:10.5455/oams.100413.or.038



Vancouver/ICMJE Style

Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty. Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines. Oxid Antioxid Med Sci. (2013), [cited December 19, 2018]; 2(2): 137-142. doi:10.5455/oams.100413.or.038



Harvard Style

Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty (2013) Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines. Oxid Antioxid Med Sci, 2 (2), 137-142. doi:10.5455/oams.100413.or.038



Turabian Style

Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty. 2013. Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines. Oxidants and Antioxidants in Medical Science, 2 (2), 137-142. doi:10.5455/oams.100413.or.038



Chicago Style

Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty. "Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines." Oxidants and Antioxidants in Medical Science 2 (2013), 137-142. doi:10.5455/oams.100413.or.038



MLA (The Modern Language Association) Style

Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty. "Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines." Oxidants and Antioxidants in Medical Science 2.2 (2013), 137-142. Print. doi:10.5455/oams.100413.or.038



APA (American Psychological Association) Style

Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty (2013) Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines. Oxidants and Antioxidants in Medical Science, 2 (2), 137-142. doi:10.5455/oams.100413.or.038





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