ISSN 2146-8389
 

Original Research (Original Article) 


Caspase-3 expression and cell morphology of early endothelial progenitor cells exposed to N-epsilon-carboxymethyl lysine

Agus Yuwono, Nur Permatasari, Dian Nugrahenny, Djanggan Sargowo, Achmad Rudijanto, Djoko Wahono Soeatmadji.

Abstract
The role of endothelial progenitor cells (EPCs) on vascular repair and neovasculogenesis is impaired in diabetes. This study aimed to investigate the effect of N-epsilon-carboxymethyl lysine (CML) on caspase-3 expression and morphology of early EPCs. After 7 days of culturing, primary cultures of early EPCs were randomly divided into four groups. One group is a normal group. Three groups were exposed to low (50 µg/ml), medium (100 µg/ml), and high (200 µg/ml) doses of CML for an hour. The caspase-3 expression and morphology of early EPCs were evaluated by laser scanning confocal microscope. The caspase-3 expression of early EPCs increased in groups exposed to low and medium dose of CML, and decreased in group exposed to high dose of CML compared to normal. Exposure of CML changed the morphology of early EPCs including cells shrinkage, unclear margin between cytoplasm and nucleus, also oval-shape cells. Given that CML may contribute to the functional defects of the endothelium in diabetes by causing early EPCs apoptosis via increased caspase-3 expression.

Key words: Endothelial progenitor cells; Caspase-3; Morphology; N-epsilon-carboxymethyl lysine


 
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PMid:16723122

How to Cite this Article
Pubmed Style

Yuwono A, Permatasari N, Nugrahenny D, Sargowo D, Rudijanto A, Soeatmadji DW. Caspase-3 expression and cell morphology of early endothelial progenitor cells exposed to N-epsilon-carboxymethyl lysine. Oxid Antioxid Med Sci. 2013; 2(2): 119-124. doi:10.5455/oams.080413.or.036


Web Style

Yuwono A, Permatasari N, Nugrahenny D, Sargowo D, Rudijanto A, Soeatmadji DW. Caspase-3 expression and cell morphology of early endothelial progenitor cells exposed to N-epsilon-carboxymethyl lysine. http://www.ejmoams.com/?mno=33923 [Access: August 18, 2018]. doi:10.5455/oams.080413.or.036


AMA (American Medical Association) Style

Yuwono A, Permatasari N, Nugrahenny D, Sargowo D, Rudijanto A, Soeatmadji DW. Caspase-3 expression and cell morphology of early endothelial progenitor cells exposed to N-epsilon-carboxymethyl lysine. Oxid Antioxid Med Sci. 2013; 2(2): 119-124. doi:10.5455/oams.080413.or.036



Vancouver/ICMJE Style

Yuwono A, Permatasari N, Nugrahenny D, Sargowo D, Rudijanto A, Soeatmadji DW. Caspase-3 expression and cell morphology of early endothelial progenitor cells exposed to N-epsilon-carboxymethyl lysine. Oxid Antioxid Med Sci. (2013), [cited August 18, 2018]; 2(2): 119-124. doi:10.5455/oams.080413.or.036



Harvard Style

Yuwono, A., Permatasari, N., Nugrahenny, D., Sargowo, D., Rudijanto, A. & Soeatmadji, D. W. (2013) Caspase-3 expression and cell morphology of early endothelial progenitor cells exposed to N-epsilon-carboxymethyl lysine. Oxid Antioxid Med Sci, 2 (2), 119-124. doi:10.5455/oams.080413.or.036



Turabian Style

Yuwono, Agus, Nur Permatasari, Dian Nugrahenny, Djanggan Sargowo, Achmad Rudijanto, and Djoko Wahono Soeatmadji. 2013. Caspase-3 expression and cell morphology of early endothelial progenitor cells exposed to N-epsilon-carboxymethyl lysine. Oxidants and Antioxidants in Medical Science, 2 (2), 119-124. doi:10.5455/oams.080413.or.036



Chicago Style

Yuwono, Agus, Nur Permatasari, Dian Nugrahenny, Djanggan Sargowo, Achmad Rudijanto, and Djoko Wahono Soeatmadji. "Caspase-3 expression and cell morphology of early endothelial progenitor cells exposed to N-epsilon-carboxymethyl lysine." Oxidants and Antioxidants in Medical Science 2 (2013), 119-124. doi:10.5455/oams.080413.or.036



MLA (The Modern Language Association) Style

Yuwono, Agus, Nur Permatasari, Dian Nugrahenny, Djanggan Sargowo, Achmad Rudijanto, and Djoko Wahono Soeatmadji. "Caspase-3 expression and cell morphology of early endothelial progenitor cells exposed to N-epsilon-carboxymethyl lysine." Oxidants and Antioxidants in Medical Science 2.2 (2013), 119-124. Print. doi:10.5455/oams.080413.or.036



APA (American Psychological Association) Style

Yuwono, A., Permatasari, N., Nugrahenny, D., Sargowo, D., Rudijanto, A. & Soeatmadji, D. W. (2013) Caspase-3 expression and cell morphology of early endothelial progenitor cells exposed to N-epsilon-carboxymethyl lysine. Oxidants and Antioxidants in Medical Science, 2 (2), 119-124. doi:10.5455/oams.080413.or.036





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