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Effects of ethanolic extracts of Gaarcinia mangostana fruit pericap on oxidant-antioxidant status and foam cells in atherosclerotic rats

Dwi Laksono Adiputro, Husnul Khotimah, M. Aris Widodo, Rochmad Romdoni, Djanggan Sargowo.

Cited by (2)

Abstract
The present study was aimed to determine whether ethanolic extract of mangosteen pericarp (EEMP) changed oxidant-antioxidant status and foam cell formation in atherosclerotic rats. Thirty two male Wistar rats were divided into five groups (n = 6 for each), including standard diet (control) group, hypercholesterolemic diet (HD) group, HD + EEMP at doses of 200, 400 and 800 mg/kg body weight. Analyses of serum H2O2 level, glutathione peroxidase (GPx) and catalase (CAT) activity were done using colorimetric methods. Foam cells counts were measured histologically with Oil Red O staining. One Way Analysis of Variance test was used to analyze the differences in all parameters. Hypercholesterolemic diet significantly increased H2O2 compared with the control group, but significantly decreased in EEMP-receiving group starting at dose of 200 mg/kg than that in HD group. There is no difference in GPx activity among all groups. Hypercholesterolemic diet decreased CAT activity compared with control group (P = 0.052), but was significantly increased in EEMP-receiving group at doses of 400 and 800 mg/kg. The levels of foam cells counts were significantly decreased in EEMP-receiving group at doses of 400 and 800 mg/kg than that in HD group. In conclusion, EEMP at dose of 400 mg/kg BW decreased oxidant levels due to modulation of catalase activity and also inhibited foam cells formation.

Key words: Catalase; Foam cells; Glutathione peroxidase; Hydrogen peroxide; Mangosteen


 
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This Article Cited By the following articles

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How to Cite this Article
Pubmed Style

Adiputro DL, Khotimah H, Widodo MA, Romdoni R, Sargowo D. Effects of ethanolic extracts of Gaarcinia mangostana fruit pericap on oxidant-antioxidant status and foam cells in atherosclerotic rats. Oxid Antioxid Med Sci. 2013; 2(1): 61-64. doi:10.5455/oams.170313.br.007


Web Style

Adiputro DL, Khotimah H, Widodo MA, Romdoni R, Sargowo D. Effects of ethanolic extracts of Gaarcinia mangostana fruit pericap on oxidant-antioxidant status and foam cells in atherosclerotic rats. http://www.ejmoams.com/?mno=33285 [Access: August 20, 2018]. doi:10.5455/oams.170313.br.007


AMA (American Medical Association) Style

Adiputro DL, Khotimah H, Widodo MA, Romdoni R, Sargowo D. Effects of ethanolic extracts of Gaarcinia mangostana fruit pericap on oxidant-antioxidant status and foam cells in atherosclerotic rats. Oxid Antioxid Med Sci. 2013; 2(1): 61-64. doi:10.5455/oams.170313.br.007



Vancouver/ICMJE Style

Adiputro DL, Khotimah H, Widodo MA, Romdoni R, Sargowo D. Effects of ethanolic extracts of Gaarcinia mangostana fruit pericap on oxidant-antioxidant status and foam cells in atherosclerotic rats. Oxid Antioxid Med Sci. (2013), [cited August 20, 2018]; 2(1): 61-64. doi:10.5455/oams.170313.br.007



Harvard Style

Adiputro, D. L., Khotimah, H., Widodo, M. A., Romdoni, R. & Sargowo, D. (2013) Effects of ethanolic extracts of Gaarcinia mangostana fruit pericap on oxidant-antioxidant status and foam cells in atherosclerotic rats. Oxid Antioxid Med Sci, 2 (1), 61-64. doi:10.5455/oams.170313.br.007



Turabian Style

Adiputro, Dwi Laksono, Husnul Khotimah, M. Aris Widodo, Rochmad Romdoni, and Djanggan Sargowo. 2013. Effects of ethanolic extracts of Gaarcinia mangostana fruit pericap on oxidant-antioxidant status and foam cells in atherosclerotic rats. Oxidants and Antioxidants in Medical Science, 2 (1), 61-64. doi:10.5455/oams.170313.br.007



Chicago Style

Adiputro, Dwi Laksono, Husnul Khotimah, M. Aris Widodo, Rochmad Romdoni, and Djanggan Sargowo. "Effects of ethanolic extracts of Gaarcinia mangostana fruit pericap on oxidant-antioxidant status and foam cells in atherosclerotic rats." Oxidants and Antioxidants in Medical Science 2 (2013), 61-64. doi:10.5455/oams.170313.br.007



MLA (The Modern Language Association) Style

Adiputro, Dwi Laksono, Husnul Khotimah, M. Aris Widodo, Rochmad Romdoni, and Djanggan Sargowo. "Effects of ethanolic extracts of Gaarcinia mangostana fruit pericap on oxidant-antioxidant status and foam cells in atherosclerotic rats." Oxidants and Antioxidants in Medical Science 2.1 (2013), 61-64. Print. doi:10.5455/oams.170313.br.007



APA (American Psychological Association) Style

Adiputro, D. L., Khotimah, H., Widodo, M. A., Romdoni, R. & Sargowo, D. (2013) Effects of ethanolic extracts of Gaarcinia mangostana fruit pericap on oxidant-antioxidant status and foam cells in atherosclerotic rats. Oxidants and Antioxidants in Medical Science, 2 (1), 61-64. doi:10.5455/oams.170313.br.007





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