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Modulation of the antioxidant status of the hearts and brains of genetically modified hypercholesterolemic mice overproducing HDL cholesterol following acute bitter yam supplementation

Dewayne Stennett, Frederick Oladeinde, Andrew Wheatley, Lowell Dilworth, Joseph Bryant, Helen Asemota.

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Abstract
The bitter yam tuber is consumed as a staple in various regions of the world and is known to possess medicinal properties due to the presence of bioactive compounds such as saponins. These compounds may induce health complications resulting in tissue damage in cases of overconsumption. This study was geared towards determining the effects of Jamaican bitter yam (5%) on tissue damage parameters in mice hearts and brains. Mice were fed diets with or without bitter yam supplementation for a period of four weeks after which they were sacrificed. Lipid peroxidation and antioxidant parameters were determined in the heart and brain. Significant increases in lipid peroxidation were observed in the hearts of mice fed bitter yam supplemented diets and in the brains of hypercholesterolemic mice only. Bitter yam supplementation significantly reduced glutathione peroxidase activities in the hearts of hypercholesterolemic mice and the hearts and brains of normocholesterolemic mice. Significant increase in catalase activity was only seen in the hearts of hypercholesterolemic mice fed a supplemented diet when compared to mice fed an unsupplemented diet. The results indicate that dietary supplementation with the Jamaican bitter yam at a high concentration may induce oxidative stress in mice hearts and brains.

Key words: Bioactive compound; Dioscorea; Genetic modification; Hypercholesterolemic; Toxic


 
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PMid:10872549

This Article Cited By the following articles

Renal and Hepatic Function in Hypercholesterolemic Rats Fed Jamaican Bitter Yam(Dioscorea polygonoides)
Journal of Dietary Supplements 2015; 12(2): 173.

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How to Cite this Article
Pubmed Style

Stennett D, Oladeinde F, Wheatley A, Dilworth L, Bryant J, Asemota H. Modulation of the antioxidant status of the hearts and brains of genetically modified hypercholesterolemic mice overproducing HDL cholesterol following acute bitter yam supplementation. Oxid Antioxid Med Sci. 2013; 2(1): 11-19. doi:10.5455/oams.040313.or.029


Web Style

Stennett D, Oladeinde F, Wheatley A, Dilworth L, Bryant J, Asemota H. Modulation of the antioxidant status of the hearts and brains of genetically modified hypercholesterolemic mice overproducing HDL cholesterol following acute bitter yam supplementation. http://www.ejmoams.com/?mno=32853 [Access: May 22, 2018]. doi:10.5455/oams.040313.or.029


AMA (American Medical Association) Style

Stennett D, Oladeinde F, Wheatley A, Dilworth L, Bryant J, Asemota H. Modulation of the antioxidant status of the hearts and brains of genetically modified hypercholesterolemic mice overproducing HDL cholesterol following acute bitter yam supplementation. Oxid Antioxid Med Sci. 2013; 2(1): 11-19. doi:10.5455/oams.040313.or.029



Vancouver/ICMJE Style

Stennett D, Oladeinde F, Wheatley A, Dilworth L, Bryant J, Asemota H. Modulation of the antioxidant status of the hearts and brains of genetically modified hypercholesterolemic mice overproducing HDL cholesterol following acute bitter yam supplementation. Oxid Antioxid Med Sci. (2013), [cited May 22, 2018]; 2(1): 11-19. doi:10.5455/oams.040313.or.029



Harvard Style

Stennett, D., Oladeinde, F., Wheatley, A., Dilworth, L., Bryant, J. & Asemota, H. (2013) Modulation of the antioxidant status of the hearts and brains of genetically modified hypercholesterolemic mice overproducing HDL cholesterol following acute bitter yam supplementation. Oxid Antioxid Med Sci, 2 (1), 11-19. doi:10.5455/oams.040313.or.029



Turabian Style

Stennett, Dewayne, Frederick Oladeinde, Andrew Wheatley, Lowell Dilworth, Joseph Bryant, and Helen Asemota. 2013. Modulation of the antioxidant status of the hearts and brains of genetically modified hypercholesterolemic mice overproducing HDL cholesterol following acute bitter yam supplementation. Oxidants and Antioxidants in Medical Science, 2 (1), 11-19. doi:10.5455/oams.040313.or.029



Chicago Style

Stennett, Dewayne, Frederick Oladeinde, Andrew Wheatley, Lowell Dilworth, Joseph Bryant, and Helen Asemota. "Modulation of the antioxidant status of the hearts and brains of genetically modified hypercholesterolemic mice overproducing HDL cholesterol following acute bitter yam supplementation." Oxidants and Antioxidants in Medical Science 2 (2013), 11-19. doi:10.5455/oams.040313.or.029



MLA (The Modern Language Association) Style

Stennett, Dewayne, Frederick Oladeinde, Andrew Wheatley, Lowell Dilworth, Joseph Bryant, and Helen Asemota. "Modulation of the antioxidant status of the hearts and brains of genetically modified hypercholesterolemic mice overproducing HDL cholesterol following acute bitter yam supplementation." Oxidants and Antioxidants in Medical Science 2.1 (2013), 11-19. Print. doi:10.5455/oams.040313.or.029



APA (American Psychological Association) Style

Stennett, D., Oladeinde, F., Wheatley, A., Dilworth, L., Bryant, J. & Asemota, H. (2013) Modulation of the antioxidant status of the hearts and brains of genetically modified hypercholesterolemic mice overproducing HDL cholesterol following acute bitter yam supplementation. Oxidants and Antioxidants in Medical Science, 2 (1), 11-19. doi:10.5455/oams.040313.or.029





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