ISSN 2146-8389
 

Original Research (Original Article) 


Comparative studies on the antioxidant potential of vanillin-producing Saccharomyces boulardii extracts

Ajay Suryavanshi, Amit Agarwal, Abhishek Kaler, Umesh Bihade, Jasmine Kaur, Kulbhushan B. Tikoo, Uttam Chand Banerjee.

Cited by (2)

Abstract
Free radical-scavenging antioxidants have the potential as protective agents against various degenerative diseases caused by oxidative damage. Microorganisms are shown to be a promising new source of natural antioxidants. In the present study, supernatant (crude extract) and different solvent extracts (ethyl acetate, n-butanol, dichloromethane) of Saccharomyces boulardii’s growth were evaluated for the antioxidant activity using free radical scavenging (1,1-Diphenyl-2-picryl hydrazyl; DPPH) assay, superoxide radical scavenging (nitroblue tetrazolium; NBT) assay, and by estimating total phenolic and flavonoid contents (TPC and TFC). Antioxidative potential of S.boulardii extract was also tested in biological system, i.e. A549 lung cancer cell line using dichlorofluoroscein diacetate (DCF-DA) assay. Organic extracts were further explored by HPLC and mass spectrometry techniques to identify active principles responsible for antioxidant activity. Comparative studies on antiradical ability (DPPH, NBT) revealed that crude extract has the highest activity than its other solvent counterparts as evident by its lower IC50 values and higher TPC and TFC. In vitro studies also showed that S.boulardii extracts effectively quench intracellular reactive oxygen species. Vanillin was identified as one of the contributing antioxidant. It was found that S.boulardii extract is an efficient scavenger of free radicals and can be exploited as a potential new source of natural antioxidants.

Key words: 1,1-Diphenyl-2-picryl hydrazyl; Dichlorofluoroscein diacetate; Nitrobluetetrazolium; Total phenolic content; Total flavonoid content


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Ajay Suryavanshi
Articles by Amit Agarwal
Articles by Abhishek Kaler
Articles by Umesh Bihade
Articles by Jasmine Kaur
Articles by Kulbhushan B. Tikoo
Articles by Uttam Chand Banerjee
on Google
on Google Scholar
Article Statistics
 Viewed: 3578
Downloaded: 805
Cited: 2

REFERENCES
1.Halliwell B. Oxygen radicals: a commonsense look at their nature and medical importance. Med Biol 1984; 62:71-7.

[Pubmed]   


2.Aruoma OI. Oxidative stress and antioxidants in human health and disease. J Am Oil Chem Soc 1998; 75:199-212.

http://dx.doi.org/10.1007/s11746-998-0032-9


3.Proctor PH. Free radicals and human disease. In: Miquel J, Quintanilha A, Weber H (eds) Handbook of Free Radicals and Antioxidants, CRC Press, Boca Raton, FL, USA, pp 209-221, 1989.


4.Bagchi K, Puri S. Free radicals and antioxidants in health and disease. East Mediterr Health J 1998; 4:350-60.


5.Jain S, Yadav H, Sinha P. Antioxidant activities of selected lactobacilli and lactococci cultures. J Dairy Res 2009; 76:385-91.

http://dx.doi.org/10.1017/S0022029909990094

[
Pubmed]   


6.Uskova MA, Kravchenko L. Antioxidant properties of lactic acid bacteria-probiotic and yogurt strains. Vopr Pitan 2009; 78:18-23.

[
Pubmed]   


7.Yen GC, Chang YC, Sheu F, Chiang H. Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. J Agr Food Chem 2001; 49:1426-31.

http://dx.doi.org/10.1021/jf001109t

[
Pubmed]   


8.Chen CH, Shaw CY, Chen CC, Tsai Y. 2,3,4-Trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran, a Novel Antioxidant, from Penicillium citrinum F5. J Nat Prod 2002; 65:740-1.

http://dx.doi.org/10.1021/np010605o

[
Pubmed]   


9.Hatoum R, Labrie S, Fliss I. Antimicrobial and probiotic properties of yeasts: from fundamental to novel applications. Front Microbiol 2012; 3:421.

http://dx.doi.org/10.3389/fmicb.2012.00421

[
Pubmed]    [PMC Free Fulltext]   


10.Zanello G, Meurens F, Berri M, Salmon H. Saccharomyces boulardii effects on gastrointestinal diseases. Curr Issues Mol Biol. 2009; 11:47-58.

[
Pubmed]   


11.Geronikaki A, Gavala A. Antioxidants and inflammatory disease: synthetic and natural antioxidants with anti-inflammatory activity. Comb Chem High Throughput Screen 2006; 9:425-42.

http://dx.doi.org/10.2174/138620706777698481

[
Pubmed]   


12.Duman DG, Kumral ZN, Ercan F, Deniz M, Can G, Caglayan Yegen B. Saccharomyces boulardii ameliorates clarithromycin- and methotrexate-induced intestinal and hepatic injury in rats. Br J Nutr. 2013; 2:1-7.

http://dx.doi.org/10.1017/S000711451200517X

[
Pubmed]   


13.Sahin T, Aydin S, Yuksel O, Bostanci H, Akyurek N, Memis L, Basaran N. Effects of the probiotic agent Saccharomyces Boulardii on the DNA damage in acute necrotizing pancreatitis induced rats. Hum Exp Toxicol. 2007; 26:653–61.

http://dx.doi.org/10.1177/0960327107077596

[
Pubmed]   


14.Murray JI, Whitfield ML, Trinklein ND, Myers RM, Brown PO, Botstein D. Diverse and specific gene expression responses to stresses in cultured human cells. Mol Biol Cell 2004; 15:2361-74.

http://dx.doi.org/10.1091/mbc.E03-11-0799

[
Pubmed]    [PMC Free Fulltext]   


15.Razali N, Razab R, Junit SM, Aziz AA. Radical scavenging and reducing properties of extracts of cashew shoots (Anacardium occidentale). Food Chem 2008; 111:38-44.

http://dx.doi.org/10.1016/j.foodchem.2008.03.024


16.Arora DS, Chandra P. Assay of antioxidant potential of two Aspergillus isolates by different methods under various physic-chemical conditions. Braz J Microbiol 2010; 41:765-77.

http://dx.doi.org/10.1590/S1517-83822010000300029


17.Arora DS, Chandra P. Antioxidant Activity of Aspergillus fumigatus. ISRN Pharmacol 2011; 2011:619395.

[
Pubmed]    [PMC Free Fulltext]   


18.Gautam R, Srivastava A, Jachak SM, Saklani A. Anti-imflammatory and antioxidant effects of Dysophylla stellata. Fitoterapia 2010; 81: 45-49.

http://dx.doi.org/10.1016/j.fitote.2009.07.004

[
Pubmed]   


19.Kiran B, Raveesha KA. In vitro evaluation of antioxidant potentiality of seeds of Psoralea corylifolia L. World Appl Sci J 2010; 8:985-90.


20.Liu X, Chen R, Shang Y, Jiao B, Huang C. Superoxide radicals scavenging and xanthine oxidase inhibitory activity of magnesium lithospermate B from Salvia miltiorrhiza. J Enzyme Inhib Med Chem 2009; 24:663-8.

http://dx.doi.org/10.1080/14756360802323829

[
Pubmed]   


21.Lee BJ, Kim JS, Kang YM, Lim JH, Kim YM, Lee MS, Jeong MH. Antioxidant activity and γ- aminobutyric acid (GABA) content in sea tangle fermented by Lactobacillus brevis BJ20 isolated from traditional fermented foods. Food Chem 2010; 122:271-6.

http://dx.doi.org/10.1016/j.foodchem.2010.02.071


22.Sonboli A, Mojarrad M, Ebrahimi SN, Enayat S. Free radical scavenging activity and total phenolic content of methanolic extracts from male inflorescence of Salix aegyptiaca grown in Iran. Iran J Pharm Res 2010; 9:293-6.


23.Asami DK, Hong YJ, Barrett DM, Mitchell A. Comparison of the total phenolic and ascorbic acid content of freeze-dried and air-dried marionberry, strawberry, and corn grown using conventional, organic, and sustainable agricultural practices. J Agr Food Chem 2003; 51:1237-41.

http://dx.doi.org/10.1021/jf020635c

[
Pubmed]   


24.Meda A, Lamien CE, Romito M, Millogo J, Nacoulma O. Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity. Food Chem 2005; 91:571-7.

http://dx.doi.org/10.1016/j.foodchem.2004.10.006


25.Zongo C, Savadogo A, Ouattara L, Bassole I, Ouattara C, Ouattara A. Polyphenols content, antioxidant and antimicrobial activities of Ampelocissus grantii (Baker) Planch. (Vitaceae): A medicinal plant from Burkina Faso. Int J Pharmacol 2010; 6:880-7.

http://dx.doi.org/10.3923/ijp.2010.880.887


26.Kang KA, Chae S, Lee KH, Zhang R, Jung MS, You HJ. Antioxidant effect of Homogentisic acid on hydrogen peroxide induced oxidative stress in human lung fibroblast cells. Biotechnol Bioproc E 2005; 10:556-63.

http://dx.doi.org/10.1007/BF02932294


27.Li T, Rosazza JP. Biocatalytic Synthesis of Vanillin. Appl Environ Microbiol 2000; 66:684-7.

http://dx.doi.org/10.1128/AEM.66.2.684-687.2000

[
Pubmed]    [PMC Free Fulltext]   


28.Motta AS, Cladera-Olivera F, Brandelli A. Screening for antimicrobial activity among bacteria isolated from the Amazon basin. Braz J Microbiol 2004; 35:307-10.

http://dx.doi.org/10.1590/S1517-83822004000300007


29.Kogan G, Pajtinka M, Babincova M, Miadokova E, Rauko P, Slamenova D, Korolenko TA. Yeast cell wall polysaccharides as antioxidants and antimutagens: can they fight cancer? Neoplasma 2008; 55:387-93.

[
Pubmed]   


30.Butylina S, Shataeva LK, Nystrom M. Separation of nucleoprotein complexes with antioxidant activity from yeast Saccharomyces cerevisiae. Sep Purif Technol 2007; 53:64-70.

http://dx.doi.org/10.1016/j.seppur.2006.06.014


31.Czerucka D, Rampal P. Effect of Saccharomyces boulardii on cAMP- and Ca2+-dependent Cl- Secretion in T84 Cells. Dig Dis Sci 1999; 44:2359-68.

http://dx.doi.org/10.1023/A:1026689628136

[
Pubmed]   


32.Xu X, Yasuda M, Mizuno M, Ashida H. β-Glucan from Saccharomyces cerevisiae reduces lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages. Biochim Biophys Acta 2012; 1820:1656-63.

http://dx.doi.org/10.1016/j.bbagen.2012.06.015

[
Pubmed]   


33.Castagliuolo I, Riegler MF, Valenick L, LaMont JM, Pothoulakis C. Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa. Infect Immun 1999; 67:302-7.

[
Pubmed]    [PMC Free Fulltext]   


34.Malpure PP, Shah AS, Juvekar A. Antioxidant and anti-inflammatory activity of extract obtained from Aspergillus candidus MTCC 2202 broth filtrate. Indian J Exp Biol 2006; 44:468-73.

[
Pubmed]   


35.Goh SH, Yusoff FM, Loh S. A comparison of the antioxidant properties and total phenolic content in a diatom, Chaetoceros sp. and a green microalga, Nannochloropsis sp. J Agr Sci 2010; 2:123-30.


36.Molyneux P. The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin J Sci Technol 2004; 26:211-9.


37.Beauchamp C, Fridovich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 1971; 44:276-87.

http://dx.doi.org/10.1016/0003-2697(71)90370-8

[
Pubmed]   


38.Moon BS, Ryoo IJ, Yun BS, Bae KS, Lee KD, Yoo ID, Kim J. Glyscavins A, B and C, new phenolic glycoside antioxidants produced by a fungus Mycelia sterilia F020054. J Antibiot 2006; 59:735-9.

http://dx.doi.org/10.1038/ja.2006.99

[
Pubmed]   


39.Singleton VL, Orthopher N, Lamuela-Raventos RO. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 1999; 299:152-78.

http://dx.doi.org/10.1016/S0076-6879(99)99017-1


40.Huang D, Prior RL, Ou B. The chemistry behind antioxidant capacity assays. J Agr Food Chem 2005; 53:1841-56.

http://dx.doi.org/10.1021/jf030723c

[
Pubmed]   


41.Chang CC, Yang MH, Wen HM, Chern J. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal 2002; 10:178-82.


42.Sava C, Sirbu R. Analytical study of the determination of flavonoids in Black Sea algae. OUAC 2010; 21:29-34.


43.Duan XJ, Zhang WW, Li XM, Wang B. Evaluation of antioxidant property of extract and fractions obtained from a red alga, Polysiphonia urceolata. Food Chem 2006; 95:37-43.

http://dx.doi.org/10.1016/j.foodchem.2004.12.015


44.Wang H, Joseph J. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 1999; 27:612-6.

http://dx.doi.org/10.1016/S0891-5849(99)00107-0

[
Pubmed]   


45.Halliwell B, Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? British J Pharmacol 2009; 142:231-55.

http://dx.doi.org/10.1038/sj.bjp.0705776

[
Pubmed]    [PMC Free Fulltext]   


46.Slamenova D, Labaj J, Krizkova L, Kogan G, Sandula J, Bresgen N, Eckl P. Protective effects of fungal (1→3)-β-D-glucan derivatives against oxidative DNA lesions in V79 hamster lung cells. Cancer Lett 2003; 198:153-60.

http://dx.doi.org/10.1016/S0304-3835(03)00336-7

[
Pubmed]   


47.Yen GC, Chiang HC, Wu CH, Yeh C. The protective effects of Aspergillus candidus metabolites against hydrogen peroxide-induced oxidative damage to Int 407 cells. Food Chem Toxicol 2003; 41:1561-7.

http://dx.doi.org/10.1016/S0278-6915(03)00174-1

[
Pubmed]   


48.Burri J, Graf M, Lambelet P, Loliger J. Vanillin: more than a flavouring agent - a potent antioxidant. J Sci Food Agr 1989; 48:49-56.

http://dx.doi.org/10.1002/jsfa.2740480107


49.Kamat JP, Ghosh A, Devasagayam TP. Vanillin as an antioxidant in rat liver mitochondria: Inhibition of protein oxidation and lipid peroxidation induced by photosensitization. Mol Cell Biochem 2000; 209:47-53.

http://dx.doi.org/10.1023/A:1007048313556

[
Pubmed]   


50.Shyamala BN, Naidu MM, Sulochanamma G, Srinivas P Studies on the antioxidant activities of natural vanilla extract and its constituent compounds through in vitro models. J Agr Food Chem 2007; 55:7738-43.

http://dx.doi.org/10.1021/jf071349+

[
Pubmed]   


This Article Cited By the following articles

Determination of antioxidant potential
J. Sci. Food Agric 2017; (): .

1
 
The Influence of ProbioticLactobacillus caseiin Combination with Prebiotic Inulin on the Antioxidant Capacity of Human Plasma
Oxidative Medicine and Cellular Longevity 2016; 2016(): 1.

2
 

How to Cite this Article
Pubmed Style

Suryavanshi A, Agarwal A, Kaler A, Bihade U, Kaur J, Tikoo KB, Banerjee UC. Comparative studies on the antioxidant potential of vanillin-producing Saccharomyces boulardii extracts. Oxid Antioxid Med Sci. 2013; 2(3): 201-209. doi:10.5455/oams.190413.or.040


Web Style

Suryavanshi A, Agarwal A, Kaler A, Bihade U, Kaur J, Tikoo KB, Banerjee UC. Comparative studies on the antioxidant potential of vanillin-producing Saccharomyces boulardii extracts. http://www.ejmoams.com/?mno=32795 [Access: August 20, 2018]. doi:10.5455/oams.190413.or.040


AMA (American Medical Association) Style

Suryavanshi A, Agarwal A, Kaler A, Bihade U, Kaur J, Tikoo KB, Banerjee UC. Comparative studies on the antioxidant potential of vanillin-producing Saccharomyces boulardii extracts. Oxid Antioxid Med Sci. 2013; 2(3): 201-209. doi:10.5455/oams.190413.or.040



Vancouver/ICMJE Style

Suryavanshi A, Agarwal A, Kaler A, Bihade U, Kaur J, Tikoo KB, Banerjee UC. Comparative studies on the antioxidant potential of vanillin-producing Saccharomyces boulardii extracts. Oxid Antioxid Med Sci. (2013), [cited August 20, 2018]; 2(3): 201-209. doi:10.5455/oams.190413.or.040



Harvard Style

Suryavanshi, A., Agarwal, A., Kaler, A., Bihade, U., Kaur, J., Tikoo, K. B. & Banerjee, U. C. (2013) Comparative studies on the antioxidant potential of vanillin-producing Saccharomyces boulardii extracts. Oxid Antioxid Med Sci, 2 (3), 201-209. doi:10.5455/oams.190413.or.040



Turabian Style

Suryavanshi, Ajay, Amit Agarwal, Abhishek Kaler, Umesh Bihade, Jasmine Kaur, Kulbhushan B. Tikoo, and Uttam Chand Banerjee. 2013. Comparative studies on the antioxidant potential of vanillin-producing Saccharomyces boulardii extracts. Oxidants and Antioxidants in Medical Science, 2 (3), 201-209. doi:10.5455/oams.190413.or.040



Chicago Style

Suryavanshi, Ajay, Amit Agarwal, Abhishek Kaler, Umesh Bihade, Jasmine Kaur, Kulbhushan B. Tikoo, and Uttam Chand Banerjee. "Comparative studies on the antioxidant potential of vanillin-producing Saccharomyces boulardii extracts." Oxidants and Antioxidants in Medical Science 2 (2013), 201-209. doi:10.5455/oams.190413.or.040



MLA (The Modern Language Association) Style

Suryavanshi, Ajay, Amit Agarwal, Abhishek Kaler, Umesh Bihade, Jasmine Kaur, Kulbhushan B. Tikoo, and Uttam Chand Banerjee. "Comparative studies on the antioxidant potential of vanillin-producing Saccharomyces boulardii extracts." Oxidants and Antioxidants in Medical Science 2.3 (2013), 201-209. Print. doi:10.5455/oams.190413.or.040



APA (American Psychological Association) Style

Suryavanshi, A., Agarwal, A., Kaler, A., Bihade, U., Kaur, J., Tikoo, K. B. & Banerjee, U. C. (2013) Comparative studies on the antioxidant potential of vanillin-producing Saccharomyces boulardii extracts. Oxidants and Antioxidants in Medical Science, 2 (3), 201-209. doi:10.5455/oams.190413.or.040





Most Viewed Articles
  • Low intensity radiofrequency radiation: a new oxidant for living cells
    Igor Yakymenko, Evgeniy Sidorik, Diane Henshel, Sergiy Kyrylenko
    Oxid Antioxid Med Sci. 2014; 3(1): 1-3
    » Abstract & References » doi: 10.5455/oams.240314.ed.002

  • Oxidants and antioxidants: friends or foes?
    Sukru Oter, Si Jin, Luca Cucullo, H.J. Damien Dorman
    Oxid Antioxid Med Sci. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/oams.080612.ed.001

  • Effects of free radicals and antioxidants on exercise performance
    Sikiru Lamina, Charles I. Ezema, Anele I. Theresa, Ezugwu U. Anthonia
    Oxid Antioxid Med Sci. 2013; 2(2): 83-91
    » Abstract & References » doi: 10.5455/oams.010413.rv.005

  • Effects of silymarin, N-acetylcysteine and selenium in the treatment of papulopustular acne
    Haidar Hamid Al-Anbari, Ahmed Salih Sahib, Ahmed R. Abu Raghif
    Oxid Antioxid Med Sci. 2012; 1(3): 201-207
    » Abstract & References » doi: 10.5455/oams.290912.or.019

  • Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines
    Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty
    Oxid Antioxid Med Sci. 2013; 2(2): 137-142
    » Abstract & References » doi: 10.5455/oams.100413.or.038

  • Antimicrobial and antioxidant properties of marine actinomycetes Streptomyces sp VITSTK7
    Mohankumar Thenmozhi, Krishnan Kannabiran
    Oxid Antioxid Med Sci. 2012; 1(1): 51-57
    » Abstract & References » doi: 10.5455/oams.270412.or.005

  • Is it oxidative or free radical stress and why does it matter?
    Boguslaw Lipinski
    Oxid Antioxid Med Sci. 2012; 1(1): 5-9
    » Abstract & References » doi: 10.5455/oams.130312.rv.001

  • Chemical properties of Monodora myristica and its protective potentials against free radicals in vitro
    Ochuko L. Erukainure, Oluwatoyin V. Oke, Folashade O. Owolabi, Funmi O. Kayode, Emmanuel E. Umanhonlen, Muhammad Aliyu
    Oxid Antioxid Med Sci. 2012; 1(2): 127-132
    » Abstract & References » doi: 10.5455/oams.080712.or.009

  • Cytotoxic and proapoptotic activities of gallic acid to human oral cancer HSC-2 cells
    Alyssa G. Schuck, Jeffrey H. Weisburg, Hannah Esan, Esther F. Robin, Ayelet R. Bersson, Jordana R. Weitschner, Tova Lahasky, Harriet L. Zuckerbraun, Harvey Babich
    Oxid Antioxid Med Sci. 2013; 2(4): 265-274
    » Abstract & References » doi: 10.5455/oams.220713.or.051

  • Phytochemical and in vitro antioxidant properties of the methanolic extract of fruits of Blighia sapida, Vitellaria paradoxa and Vitex doniana
    Rabiat U. Hamzah, Evans C. Egwim, Adamu Y. Kabiru, Mary B. Muazu
    Oxid Antioxid Med Sci. 2013; 2(3): 217-223
    » Abstract & References » doi: 10.5455/oams.090513.or.043

  • Most Downloaded
  • Low intensity radiofrequency radiation: a new oxidant for living cells
    Igor Yakymenko, Evgeniy Sidorik, Diane Henshel, Sergiy Kyrylenko
    Oxid Antioxid Med Sci. 2014; 3(1): 1-3
    » Abstract & References » doi: 10.5455/oams.240314.ed.002

  • Oxidants and antioxidants: friends or foes?
    Sukru Oter, Si Jin, Luca Cucullo, H.J. Damien Dorman
    Oxid Antioxid Med Sci. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/oams.080612.ed.001

  • The antioxidant capacity and immunomodulatory activity of stingless bee honeys proceeding from Costa Rica
    Gabriel Zamora, Kees Beukelman, Bert van den Berg, Maria Laura Arias, Eduardo Umana, Ingrid Aguilar, Linda Quarles van Ufford, Edwin van den Worm, Natalia Fallas, Rebeca Solorzano
    Oxid Antioxid Med Sci. 2015; 4(1): 49-55
    » Abstract & References » doi: 10.5455/oams.180415.or.084

  • Is it oxidative or free radical stress and why does it matter?
    Boguslaw Lipinski
    Oxid Antioxid Med Sci. 2012; 1(1): 5-9
    » Abstract & References » doi: 10.5455/oams.130312.rv.001

  • Antimicrobial and antioxidant properties of marine actinomycetes Streptomyces sp VITSTK7
    Mohankumar Thenmozhi, Krishnan Kannabiran
    Oxid Antioxid Med Sci. 2012; 1(1): 51-57
    » Abstract & References » doi: 10.5455/oams.270412.or.005

  • Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines
    Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty
    Oxid Antioxid Med Sci. 2013; 2(2): 137-142
    » Abstract & References » doi: 10.5455/oams.100413.or.038

  • Effects of free radicals and antioxidants on exercise performance
    Sikiru Lamina, Charles I. Ezema, Anele I. Theresa, Ezugwu U. Anthonia
    Oxid Antioxid Med Sci. 2013; 2(2): 83-91
    » Abstract & References » doi: 10.5455/oams.010413.rv.005

  • Protective properties of complex of quercetin, selenium, catechins and curcumin against DNA damage
    Jana Kadrabova, Marica Krajcovicova-Kudlackova, Alexander Madaric, Martina Valachovicova, Csilla Mislanova, Maria Korenovska
    Oxid Antioxid Med Sci. 2012; 1(3): 179-184
    » Abstract & References » doi: 10.5455/oams.180912.or.018

  • Airway antioxidant capacity and pH in chronic obstructive pulmonary disease
    Wei Lee, Hsien Loo, Paul S. Thomas
    Oxid Antioxid Med Sci. 2012; 1(3): 153-160
    » Abstract & References » doi: 10.5455/oams.300812.or.016

  • Heparin or EDTA; anticoagulant of choice in free radical estimation?
    Kuldeep Mohanty, Swetasmita Mishra, Jhumur Pani, Tarannum Hasan, Abhishek Purohit, Subhadra Sharma, Rima Dada
    Oxid Antioxid Med Sci. 2012; 1(1): 21-24
    » Abstract & References » doi: 10.5455/oams.130512.br.001

  • Most Cited Articles
  • Chemical properties of Monodora myristica and its protective potentials against free radicals in vitro
    Ochuko L. Erukainure, Oluwatoyin V. Oke, Folashade O. Owolabi, Funmi O. Kayode, Emmanuel E. Umanhonlen, Muhammad Aliyu
    Oxid Antioxid Med Sci. 2012; 1(2): 127-132
    » Abstract & References » doi: 10.5455/oams.080712.or.009
    Cited : 13 times [Click to see citing articles]

  • Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines
    Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty
    Oxid Antioxid Med Sci. 2013; 2(2): 137-142
    » Abstract & References » doi: 10.5455/oams.100413.or.038
    Cited : 11 times [Click to see citing articles]

  • Role of free radicals and antioxidants in gynecological cancers: current status and future prospects
    Lokanatha Valluru, Subramanyam Dasari, Rajendra Wudayagiri
    Oxid Antioxid Med Sci. 2014; 3(1): 15-26
    » Abstract & References » doi: 10.5455/oams.201113.rv.011
    Cited : 10 times [Click to see citing articles]

  • Silymarin and naringenin protects nicotine induced oxidative stress in young rats
    Anshu Jain, Nidhi Dwivedi, Rakesh Bhargava, Swaran J.S. Flora
    Oxid Antioxid Med Sci. 2012; 1(1): 41-49
    » Abstract & References » doi: 10.5455/oams.130412.or.004
    Cited : 9 times [Click to see citing articles]

  • Phytochemical and in vitro antioxidant properties of the methanolic extract of fruits of Blighia sapida, Vitellaria paradoxa and Vitex doniana
    Rabiat U. Hamzah, Evans C. Egwim, Adamu Y. Kabiru, Mary B. Muazu
    Oxid Antioxid Med Sci. 2013; 2(3): 217-223
    » Abstract & References » doi: 10.5455/oams.090513.or.043
    Cited : 9 times [Click to see citing articles]

  • Palm vitamin E reduces oxidative stress, and physical and morphological alterations of erythrocyte membranes in streptozotocin-induced diabetic rats
    Fatmah Ali Matough, Siti Balkis Budin, Zariyantey Abdul Hamid, Santhana Raj Louis, Nasar Alwahaibi, Jamaludin Mohamed
    Oxid Antioxid Med Sci. 2012; 1(1): 59-68
    » Abstract & References » doi: 10.5455/oams.300412.or.006
    Cited : 8 times [Click to see citing articles]

  • Peroxidative index as novel marker of hydrogen peroxide involvement in lipid peroxidation from coal dust exposure
    Nia Kania, Bambang Setiawan, Edi Widjajanto, Nurdiana Nurdiana, M. Aris Widodo, H.M.S. Chandra Kusuma
    Oxid Antioxid Med Sci. 2012; 1(3): 209-215
    » Abstract & References » doi: 10.5455/oams.031012.or.020
    Cited : 8 times [Click to see citing articles]

  • Cytotoxic and proapoptotic activities of gallic acid to human oral cancer HSC-2 cells
    Alyssa G. Schuck, Jeffrey H. Weisburg, Hannah Esan, Esther F. Robin, Ayelet R. Bersson, Jordana R. Weitschner, Tova Lahasky, Harriet L. Zuckerbraun, Harvey Babich
    Oxid Antioxid Med Sci. 2013; 2(4): 265-274
    » Abstract & References » doi: 10.5455/oams.220713.or.051
    Cited : 7 times [Click to see citing articles]

  • Heparin or EDTA; anticoagulant of choice in free radical estimation?
    Kuldeep Mohanty, Swetasmita Mishra, Jhumur Pani, Tarannum Hasan, Abhishek Purohit, Subhadra Sharma, Rima Dada
    Oxid Antioxid Med Sci. 2012; 1(1): 21-24
    » Abstract & References » doi: 10.5455/oams.130512.br.001
    Cited : 6 times [Click to see citing articles]

  • Antimicrobial and antioxidant properties of marine actinomycetes Streptomyces sp VITSTK7
    Mohankumar Thenmozhi, Krishnan Kannabiran
    Oxid Antioxid Med Sci. 2012; 1(1): 51-57
    » Abstract & References » doi: 10.5455/oams.270412.or.005
    Cited : 6 times [Click to see citing articles]