ISSN 2146-8389
 

Original Research (Original Article) 


Ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in male albino rats

Saber A. Sakr, Hoda A. Mahran, Marwa M. El-Deeb.

Cited by (4)

Abstract
Fluoxetine is a selective serotonin reuptake inhibitor used to treat depression and mood disorders. Curcumin, the major active ingredient of turmeric (Curcuma longa), showed many pharmacological effects and is known for its potent antioxidant capacity. The present work aims to evaluate the possible ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in albino rats. Histological examination of testis of fluoxetine-treated rats revealed degeneration of spermatogenic cells, congestion of blood vessels and destruction of Leydig cells. In addition, speramatogenesis was inhibited as indicated by the decrease of the number of different spermatogenic cells. The diameters of the seminiferous tubules and heights of their germinal epithelium were significantly reduced. Moreover, significant higher numbers of Bax-positive Leydig cells were recorded. Testosterone, luteinizing hormone (LH) and glutathione (GSH) were decreased while malondialdehyde were increased in sera of fluoxetine-treated animals. Treating animals with fluoxetine followed by curcumin revealed an improvement in the histological changes observed in animals treated with fluoxetine. Moreover, curcumin treatment leads to decrease in the number of Bax-positive cells, increase in testosterone, LH, GSH, and decrease of lipid peroxidation. According to the present results, it can be concluded that combined treatment with fluoxetine and curcumin can improve the testicular abnormalities induced by fluoxetine. This effect of curcumin may be attributed to its antioxidant properties.

Key words: Bax; Curcumin; Fluoxetine; Lipid peroxidation; Testis


 
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PMid:15203111

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How to Cite this Article
Pubmed Style

Sakr SA, Mahran HA, El-Deeb MM. Ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in male albino rats. Oxid Antioxid Med Sci. 2013; 2(1): 29-35. doi:10.5455/oams.140213.or.027


Web Style

Sakr SA, Mahran HA, El-Deeb MM. Ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in male albino rats. http://www.ejmoams.com/?mno=32206 [Access: May 22, 2018]. doi:10.5455/oams.140213.or.027


AMA (American Medical Association) Style

Sakr SA, Mahran HA, El-Deeb MM. Ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in male albino rats. Oxid Antioxid Med Sci. 2013; 2(1): 29-35. doi:10.5455/oams.140213.or.027



Vancouver/ICMJE Style

Sakr SA, Mahran HA, El-Deeb MM. Ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in male albino rats. Oxid Antioxid Med Sci. (2013), [cited May 22, 2018]; 2(1): 29-35. doi:10.5455/oams.140213.or.027



Harvard Style

Sakr, S. A., Mahran, H. A. & El-Deeb, M. M. (2013) Ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in male albino rats. Oxid Antioxid Med Sci, 2 (1), 29-35. doi:10.5455/oams.140213.or.027



Turabian Style

Sakr, Saber A., Hoda A. Mahran, and Marwa M. El-Deeb. 2013. Ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in male albino rats. Oxidants and Antioxidants in Medical Science, 2 (1), 29-35. doi:10.5455/oams.140213.or.027



Chicago Style

Sakr, Saber A., Hoda A. Mahran, and Marwa M. El-Deeb. "Ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in male albino rats." Oxidants and Antioxidants in Medical Science 2 (2013), 29-35. doi:10.5455/oams.140213.or.027



MLA (The Modern Language Association) Style

Sakr, Saber A., Hoda A. Mahran, and Marwa M. El-Deeb. "Ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in male albino rats." Oxidants and Antioxidants in Medical Science 2.1 (2013), 29-35. Print. doi:10.5455/oams.140213.or.027



APA (American Psychological Association) Style

Sakr, S. A., Mahran, H. A. & El-Deeb, M. M. (2013) Ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in male albino rats. Oxidants and Antioxidants in Medical Science, 2 (1), 29-35. doi:10.5455/oams.140213.or.027





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