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Original Research (Original Article) 


The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats

Ola A. Gharib, Usama A. Abd-Ellatif, Nadia M. Abdellah, Marwa A. Mohammad.

Cited by (1)

Abstract
Silymarin, a chemical extracted from the herb milk thistle, is a widely known antioxidant, hepatoprotective and anti-carcinogenic. It suppresses the oxidative injury induced by trichloroethylene (TCE) which is considered as an environmental pollutant by increasing the endogenous antioxidant in animal tissues. Twenty four male albino rats were divided into (1) control, (2) silymarin-treated, (3) TCE-exposure, (4) and silymarin plus TCE combination groups. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGTP) and alkaline phosphatase (ALP) enzyme activities, and concentrations of total cholesterol (TC), triglycerides (TGs), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), urea and creatinine were analyzed. Additionally, lipid peroxidation (malondialdehyde, MDA), nitric oxide (NO), reduced glutathione (GSH) levels in liver as well as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were measured. Liver Zn, Cu, Fe and Mn concentrations were also analyzed. TCE exposure increased serum ALT, AST, GGTP and ALP activities, TC, TGs, LDL-c, urea and creatinine concentrations, as well as MDA, NO, Zn, Cu, Fe and Mn concentration in liver, whereas it decreased SOD, GSH-Px activities, reduced GSH level in liver, and HDL-c in serum. Silymarin treatment significantly improved lipid peroxidation and oxidative injury induced by TCE. The study indicated that silymarin treatment ameliorate the harmful effect induced by TCE, taking in consideration the effect of silymarin as a free radical scavenger.

Key words: Liver; Rats; Silymarin; Trichloroethylene


 
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REFERENCES
1.Jemal A, Siegel R, Ward E. Murray T, Xu J, Thun MJ. Cancer statistics. CA Cancer J Clin 2007; 57:43-66.

http://dx.doi.org/10.3322/canjclin.57.1.43

[Pubmed]   


2.Jane C, Caldwell, Keshava N. Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis. Environ Health Perspect 2006; 114:1457-63.

http://dx.doi.org/10.1289/ehp.8692

[PMC Free Fulltext]   


3.Lash LH, Parker JC. Hepatic and renal toxicities associated with trichloroethylene. Pharmacol Rev 2001; 53:177-208.

[Pubmed]   


4.Chiu WA, Okino MS, Lipscomb JC, Evans MV. Issues in the pharmacokinetics of trichloroethylene and its metabolites. Environ Perspect 2006; 114:1450-56.

http://dx.doi.org/10.1289/ehp.8691

[PMC Free Fulltext]   


5.Chen YC, Shen SC, Lee WR, Hou WC, Yang LL. Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alterative expression of P21 protein in hepatocellular carcinoma cells SK-HEP-1. Arch Toxicol 2002; 76:351-9.

http://dx.doi.org/10.1007/s00204-002-0346-6

[Pubmed]   


6.Hendrikss JJ, de Vries HE, Van der Pol SM, Van den Berg TK, Van Toi EA, Dijkstra CD. Flavonoids inhibit myelin phagocytosis by macrophages. A structure- activity relationship study. Biochem Pharmacol 2003; 65:877-85.

http://dx.doi.org/10.1016/S0006-2952(02)01609-X

[Pubmed]   


7.Bors W, Michel C, Stettmaier K. Structure-activity relationships governing antioxidant capacities of plants polyphenols. Methods Enzymol 2001; 335:166-80.

http://dx.doi.org/10.1016/S0076-6879(01)35241-2

[Pubmed]   


8.Rui YC. Advances in pharmacological studies of silymarin. Mem Inst Oswaldo Cruz 1991; 86:79-86.

http://dx.doi.org/10.1590/S0074-02761991000600020

[Pubmed]   


9.Tong S, Chu C, Wei Y, Wang L, Gao X, Xu X, Yu J. Preparation and effects of 2,3-dehydrosilymarin, a promising and potent antioxidant and free radical scavenger. J Pharm Pharmacol 2011; 63:238-44.

http://dx.doi.org/10.1111/j.2042-7158.2010.01210.x

[Pubmed]   


10.Shaker E, Mahmoud H, Mnaa S. Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage. Food Chem Toxicol 2010; 48:803-6.

http://dx.doi.org/10.1016/j.fct.2009.12.011

[Pubmed]   


11.Feher J, Lengvel G. Silymarin in the prevention and treatment of liver diseases and primary liver cancer. Curr Pharm Biotechnol 2012; 13:210-7.

http://dx.doi.org/10.2174/138920112798868818

[Pubmed]   


12.Dunnick JK, Singh B, Nyska A, Peckham J, Kissling GE, Sanders JM. Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle. Toxicol Pathol 2011; 39:398-409.

http://dx.doi.org/10.1177/0192623310394211

[Pubmed]   


13.Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res 2000; 124:491-504.

[Pubmed]   


14.Mereish KA, Bunner DL, Regland DR, Creasia DA. Protection against microcystin-LR-induced hepatotoxicity by silymarin: biochemistry, histopathology and lethality. Pharm Res 1991; 8:273-7.

http://dx.doi.org/10.1023/A:1015868809990

[Pubmed]   


15.Toraason M, Clark J, Dankovic D, Mathias P, Skaggs S, Walker C, Werren D. Oxidative stress and DNA damage in Fischer rats following acute exposure to trichloroethylene or perchloroethylene. Toxicology 1999; 1138:43-53.

http://dx.doi.org/10.1016/S0300-483X(99)00083-9

[Pubmed]   


16.Belfield A, Goldberg DM. Revised assay for serum phenyl phosphatase activity using 4-amino-antipyrine. Enzyme 1971; 12:561-73.

[Pubmed]   


17.Szasz G. New substances for measuring gamma-glutamyl transpeptidase activity. Z Klin Chem Klin Biochem. 1974; 12:228.

[Pubmed]   


18.Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic pyruvic transaminases. Am J Clin Pathol 1957; 28:56-63.

[Pubmed]   


19.Castelli WP. The triglyceride issue: a view from Framingham. Am Heart J 1986; 112:432-7.

http://dx.doi.org/10.1016/0002-8703(86)90296-6

[Pubmed]   


20.Lopes-Virella MF, Stone P, Ellis S, Colwell JA. Cholesterol determination in high density lipoproteins separated by three different methods. Clin Chem 1977; 23:882-4.

[Pubmed]   


21.Meiattini F, Prencipe L, Bardelli F, Giannini G, Tarli P. The 4-hydroxybenzoate/4-amino phenazone chromogentic system used in the enzymatic determination of serum cholesterol. Clin Chem 1978; 24:2161-5.

[Pubmed]   


22.Bucolo G, David H. Quantitative determination of serum triglyceride by the use of enzyme. Clin Chem 1973; 19:476-82.

[Pubmed]   


23.Patton CJ, Crouch SR. Spectrophotometric and kinetics investigation of the Berthelot reaction for the determination of ammonia. Anal Chem 1977; 49:464-9.

http://dx.doi.org/10.1021/ac50011a034


24.Folin OZ. Laboratory Manual of Biological Chemistry. Appleton, New York, NY, USA, 1943.


25.Yoshioka T, Kawada K, Shimada T, Movi M. Lipid peroxidation in maternal and cord blood and protective mechanism against activated oxygen toxicity in the blood. Am J Obstet Gynecol 1979; 135:372-6.

[Pubmed]   


26.Moshage H, Kok B, Huizenga JR, Jansen PLM. Nitrite and nitrate determination in plasma: a critical evaluation. Clin Chem 1995; 41:892-6.

[Pubmed]   


27.Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959; 82:70-7.

http://dx.doi.org/10.1016/0003-9861(59)90090-6

[Pubmed]   


28.Marklund S, Marklund G. Involvement of the superoxide anion radical in the antioxidation of pyrogallol and convenient assay for superoxide dismutase. Eur J Biochem 1974; 47:469-74.

http://dx.doi.org/10.1111/j.1432-1033.1974.tb03714.x

[Pubmed]   


29.Gross RT, Bracci R, Rudolph N, Schroeder E, Kochen JA. Hydrogen peroxide toxicity and detoxification in the erythrocytes of newborn infants. Blood 1967; 29:481-93.

[Pubmed]   


30.International Atomic Energy Agency (IAEA). Elemental Analysis of Biological Materials: Current Problems and Techniques With Special Reference to Trace Elements. IAEA Technical Reports Series, Vienna, Austria, 1980.


31.Kingston HM, Jassie LB. Introduction to Microwave Sample Preparation: Theory and Practice. American Chemical Society Professional Reference Book, Washington DC, USA, p 263, 1988.


32.Gregus Z, Klaassen CD. Disposition of metals in rats: A comparative study of fecal urinary and billary excretion and tissue distribution of eighteen metals. Toxicol Appl Pharmacol 1986; 85:24-38.

http://dx.doi.org/10.1016/0041-008X(86)90384-4

[Pubmed]   


33.Gharib OA, Gharib MA. Kombucha tea ameliorates trichloroethylene induced hepatic damage in rats via inhibition of oxidative stress and free radical induction. Egypt J Sci Applic 2008; 21:481-98.


34.Gharib OA. Effects of Kombucha on oxidative stress induced nephrotoxicity in rats. Chin Med 2009; 4:23.

http://dx.doi.org/10.1186/1749-8546-4-23

[Pubmed]    [PMC Free Fulltext]   


35.Bronley-DeLancey A, McMillan DC, McMillan JM, Jollow DJ, Mohr LC, Hoel DG. Application of cryopreserved human hepatocyte in trichloroethylene risk assessment: relative disposition of choral hydrate to trichloroacetate and tricholoroethanol. Environ Health Perspect 2006; 114:1237-42.

http://dx.doi.org/10.1289/ehp.9047

[Pubmed]    [PMC Free Fulltext]   


36.Daniel S, Pratt MD, Marshall M, Kaplan MD. Evaluation of abnormal liver enzyme results in asymptomatic patients. N Engl J Med 2000; 342:1266-71.

http://dx.doi.org/10.1056/NEJM200004273421707

[Pubmed]   


37.Brown MS, Kovanen PT, Goldstein JI. Regulation of plasma cholesterol by lipoprotein receptor. Science 1981; 212:628-35.

http://dx.doi.org/10.1126/science.6261329

[Pubmed]   


38.Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004; 114(2): 147-152.

[Pubmed]    [PMC Free Fulltext]   


39.Khan S, Priyamvada S, Khan SA, Khan W, Farooq N, Khan F, Yusufi AN. Effect of trichloroethylene (TCE) toxicity on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in kidney and other rat tissues. Food Chem Toxicol 2009; 47:1562-8.

http://dx.doi.org/10.1016/j.fct.2009.04.002

[Pubmed]   


40.Chen SJ, Wang JL, Chen JH, Huang RN. Possible involvement of glutathione and p53 in trichloroethylene and percholoroethylene. Induced lipid peroxidation and apoptosis in human lung cancer cells. Free Radic Biol Med 2002; 33:464-72.

http://dx.doi.org/10.1016/S0891-5849(02)00817-1


41.Shen T, Zhu Q, Yang S, Ding R, Ma T, Ye LP, Wang LJ, Liang ZZ, Zhang XJ. Trichloroethylene induces nitric oxide production and nitric oxide synthase mRNA expression in cultured normal human epidermal keratinocytes. Toxicology 2007; 239:186-94.

http://dx.doi.org/10.1016/j.tox.2007.07.006

[Pubmed]   


42.Dashti HM, al-Sayer H, Behbehani A, Madda J, Christenson JT. Liver cirrhosis induced by carbon tetrachloride and the effect of superoxide dismutase and xanthine oxidase inhibitor treatment. JR Coll Surg Edinb 1992; 37:23-8.

[Pubmed]   


43.Keen CL, Ensunsa JL, Watson MH, Baly DL, Donovan SM, Monaco MH, Clegg MS. Nutritional aspects of manganese for experimental studies. Neurotoxicology 1999; 20:213-23.

[Pubmed]   


44.Wickens A. PDR(R) for herbal medicines. Libr J 1999; 124:74.


45.Jain A, Dwivedi N, Bhargava R, Flora SJ. Silymarin and naringenin protects nicotine induced oxidative stress in young rats. Oxid Antioxid Med Sci 2012; 1:41-9.

http://dx.doi.org/10.5455/oams.130412.or.004


46.Bosisio E, Benelli C, Pirola O. Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. Pharmacol Res 1992; 25:147-54.

http://dx.doi.org/10.1016/1043-6618(92)91383-R

[Pubmed]   


47.Sonnenbichler J, Zetl I. Biochemical effects of flavonolignan silybinin on RNA, protein and DNA synthesis in rat livers. Prog Clin Biol Res 1986; 213:319-31.

[Pubmed]   


48.Halim AB, Elahmady C, Hassab Allah S, Abdelgalil F, Hafez Y,Darwish A. Biochemical effect of antioxidant on lipid and liver function in experimentally induced liver damage. Ann Clin Biochem 1997; 34:656-63.

[Pubmed]   


49.Campos R, Garrido A, Guerra R, Valenzuela A. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Med 1989; 55:417-9.

http://dx.doi.org/10.1055/s-2006-962055

[Pubmed]   


50.Mansour HH, Hafez HF, Fahmy NM. Silymarin Modulates Cisplatin-induced oxidative stress and hepatotoxicity in rats. J Biochem Mol Biol 2006; 39:656-61.

http://dx.doi.org/10.5483/BMBRep.2006.39.6.656

[Pubmed]   


51.Ramadan L, Roushdy HM, Abu Senna GM, Amin NE, El-Deshw OA. Radioprotectve effect of silymarin against radiation induced hepatotoxicity. Pharmacol Res 2002; 45:447-52.

http://dx.doi.org/10.1006/phrs.2002.0990

[Pubmed]   


This Article Cited By the following articles

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1
 

How to Cite this Article
Pubmed Style

Gharib OA, Abd-Ellatif UA, Abdellah NM, Mohammad MA. The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats. Oxid Antioxid Med Sci. 2012; 1(3): 193-200. doi:10.5455/oams.301012.or.023

Web Style

Gharib OA, Abd-Ellatif UA, Abdellah NM, Mohammad MA. The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats. http://www.ejmoams.com/?mno=26019 [Access: August 20, 2018]. doi:10.5455/oams.301012.or.023

AMA (American Medical Association) Style

Gharib OA, Abd-Ellatif UA, Abdellah NM, Mohammad MA. The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats. Oxid Antioxid Med Sci. 2012; 1(3): 193-200. doi:10.5455/oams.301012.or.023


Vancouver/ICMJE Style

Gharib OA, Abd-Ellatif UA, Abdellah NM, Mohammad MA. The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats. Oxid Antioxid Med Sci. (2012), [cited August 20, 2018]; 1(3): 193-200. doi:10.5455/oams.301012.or.023


Harvard Style

Gharib, O. A., Abd-Ellatif, U. A., Abdellah, N. M. & Mohammad, M. A. (2012) The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats. Oxid Antioxid Med Sci, 1 (3), 193-200. doi:10.5455/oams.301012.or.023


Turabian Style

Gharib, Ola A., Usama A. Abd-Ellatif, Nadia M. Abdellah, and Marwa A. Mohammad. 2012. The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats. Oxidants and Antioxidants in Medical Science, 1 (3), 193-200. doi:10.5455/oams.301012.or.023


Chicago Style

Gharib, Ola A., Usama A. Abd-Ellatif, Nadia M. Abdellah, and Marwa A. Mohammad. "The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats." Oxidants and Antioxidants in Medical Science 1 (2012), 193-200. doi:10.5455/oams.301012.or.023


MLA (The Modern Language Association) Style

Gharib, Ola A., Usama A. Abd-Ellatif, Nadia M. Abdellah, and Marwa A. Mohammad. "The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats." Oxidants and Antioxidants in Medical Science 1.3 (2012), 193-200. Print. doi:10.5455/oams.301012.or.023


APA (American Psychological Association) Style

Gharib, O. A., Abd-Ellatif, U. A., Abdellah, N. M. & Mohammad, M. A. (2012) The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats. Oxidants and Antioxidants in Medical Science, 1 (3), 193-200. doi:10.5455/oams.301012.or.023




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