ISSN 2146-8389
 

Original Research (Original Article) 


Carbamazepine provoked hepatotoxicity: attenuation by vitamin C

Thaakur Santhrani, Eswaran Maheswari, Ganesan Rajalakshmi Saraswathy.

Cited by (2)

Abstract
Antiepileptic drugs are reported to be potentially hepatotoxic. The present study evaluates the hepatoprotective activity of vitamin C against carbamazepine induced hepatotoxicity. Rats were treated with carbamazepine (50 mg/kg p.o.) and carbamazepine supplemented with 50, 100 and 200 mg/kg vitamin C for 45 days, after which blood samples were collected and subjected to liver function tests. Animals were sacrificed, liver was isolated, weighed and the levels of antioxidants were estimated along with histopathological investigations. Serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, alkaline phosphatase, bilirubin, lipid peroxidation, absolute and relative liver weights were significantly elevated, whereas serum levels of albumin, total protein and body weight was decreased in the carbamazepine treated animals. Carbamazepine also caused vacuolar degeneration, centrilobular congestion and hepatic necrosis as evidenced from histopathological report. Vitamin C significantly reduced the levels of serum transaminases, alkaline phosphatase, bilirubin and liver weight along with an increase in total protein, albumin and body weight. It was also observed that vitamin C increased the glutathione content, reduced lipid peroxidation in liver samples and also reversed the carbamazepine induced histopathological abnormalities. Carbamazepine’s toxic metabolite epoxide induces oxidative stress; vitamin C by virtue of its antioxidant capacity reduced the oxidative stress and reversed the carbamazepine induced hepatic damage.

Key words: Carbamazepine; Hepatotoxicity; Oxidative stress; Vitamin C


 
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PMid:19833166

This Article Cited By the following articles

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How to Cite this Article
Pubmed Style

Santhrani T, Maheswari E, Saraswathy GR. Carbamazepine provoked hepatotoxicity: attenuation by vitamin C. Oxid Antioxid Med Sci. 2013; 2(1): 37-43. doi:10.5455/oams.270113.or.026


Web Style

Santhrani T, Maheswari E, Saraswathy GR. Carbamazepine provoked hepatotoxicity: attenuation by vitamin C. http://www.ejmoams.com/?mno=26003 [Access: May 22, 2018]. doi:10.5455/oams.270113.or.026


AMA (American Medical Association) Style

Santhrani T, Maheswari E, Saraswathy GR. Carbamazepine provoked hepatotoxicity: attenuation by vitamin C. Oxid Antioxid Med Sci. 2013; 2(1): 37-43. doi:10.5455/oams.270113.or.026



Vancouver/ICMJE Style

Santhrani T, Maheswari E, Saraswathy GR. Carbamazepine provoked hepatotoxicity: attenuation by vitamin C. Oxid Antioxid Med Sci. (2013), [cited May 22, 2018]; 2(1): 37-43. doi:10.5455/oams.270113.or.026



Harvard Style

Santhrani, T., Maheswari, E. & Saraswathy, G. R. (2013) Carbamazepine provoked hepatotoxicity: attenuation by vitamin C. Oxid Antioxid Med Sci, 2 (1), 37-43. doi:10.5455/oams.270113.or.026



Turabian Style

Santhrani, Thaakur, Eswaran Maheswari, and Ganesan Rajalakshmi Saraswathy. 2013. Carbamazepine provoked hepatotoxicity: attenuation by vitamin C. Oxidants and Antioxidants in Medical Science, 2 (1), 37-43. doi:10.5455/oams.270113.or.026



Chicago Style

Santhrani, Thaakur, Eswaran Maheswari, and Ganesan Rajalakshmi Saraswathy. "Carbamazepine provoked hepatotoxicity: attenuation by vitamin C." Oxidants and Antioxidants in Medical Science 2 (2013), 37-43. doi:10.5455/oams.270113.or.026



MLA (The Modern Language Association) Style

Santhrani, Thaakur, Eswaran Maheswari, and Ganesan Rajalakshmi Saraswathy. "Carbamazepine provoked hepatotoxicity: attenuation by vitamin C." Oxidants and Antioxidants in Medical Science 2.1 (2013), 37-43. Print. doi:10.5455/oams.270113.or.026



APA (American Psychological Association) Style

Santhrani, T., Maheswari, E. & Saraswathy, G. R. (2013) Carbamazepine provoked hepatotoxicity: attenuation by vitamin C. Oxidants and Antioxidants in Medical Science, 2 (1), 37-43. doi:10.5455/oams.270113.or.026





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