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Alteration in serum levels of selenium and glutathione peroxidase in acute myocardial infarction

Meral Gunaldi, Aysen Helvaci, Mehmet Zorlu, Muharrem Kiskac, Nergis Ekmen, Gulay Yilmaz.

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Abstract
Atherosclerosis is a vascular disease that occurs primarily in the aorta, coronary arteries and cerebral arteries with thickening of arteries and loss of elasticity. Despite decreased antioxidant activity documented among patients with atherosclerosis, the relationship between atherosclerosis and levels of antioxidants is still unknown. The present study was designed to evaluate serum levels of selenium and glutathione peroxidase (GPx) in patients with acute myocardial infarction with respect to healthy controls. A total of 20 patients (mean age 53.9 11.1 years; 65% were males) in the myocardial infarction with ST-segment elevation group were compared with 29 subjects (mean age 46.9 13.6 years; 55.2% were females) in the control group in terms of serum selenium and GPx levels. Patients with chronic diseases such as diabetes mellitus, hypertension, chronic renal disease, chronic liver disease, malignancy, prior cardiac events were not included. As result, there was a significant reduction in serum selenium levels of patient with myocardial infarction when compared to control subjects. However patient and control groups were similar in terms of serum GPx levels. In conclusion, since serum levels of Se are directly proportional to GPx activity but inversely proportional to the age, addition of Se to the diet in elderly patients seems to have a benefit in increasing antioxidant protection.

Key words: Acute myocardial infarction; Antioxidant; Glutathione peroxidase; Selenium


 
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REFERENCES
1.Hennekens CH. Increasing burden of cardiovascular disease. Current knowledge and future directions for research on rise factors. Circulation 1998; 97:1095-102.

http://dx.doi.org/10.1161/01.CIR.97.11.1095

[Pubmed]   


2.Sies H. Oxidative stress: introdoctory remarks. In: Sies H (ed) Oxidative Stress, Academic Press, San Diego, New York, London, pp 1-8, 1985.


3.Sies H. Strategies of antioxidant defense. Eur J Biochem 1993; 215:213-9.

http://dx.doi.org/10.1111/j.1432-1033.1993.tb18025.x

[
Pubmed]   


4.Schwenke DC. Antioxidants and atherogenesis. J Nutr Biochem 1998; 9:424-45.

http://dx.doi.org/10.1016/S0955-2863(98)00046-1


5.Paglia DE, Valetine WN. Studies on the quantitative and qualitative characterization of erytrocyte glutathione peroxidase. J Lab Clin Med 1967; 70:158-69.

[
Pubmed]   


6.Westhuyzen J. The oxidation hypothesis of atherosclerosis: an update. Ann Clin Lab Sci 1997; 27:1-10.

[
Pubmed]   


7.Uysal M. Atherosclerosis, cardiovascular diseases and free radicals. Aktuel Tip Dergisi 2000; 5:15-21.


8.Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, Giampaoli S, Jansen A, Menotti A, Nedeljkovic S, Pekkarinen M, Simic BS, Toshima H, Feskens EJM, Hollman PCH, Katan MB. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med 1995; 155:381-6.

http://dx.doi.org/10.1001/archinte.1995.00430040053006

[
Pubmed]   


9.Roux S, Loffler BM, Gray GA, Sprecher U, Clozel M, Clozel JP. The role of endothelin in experimental cerebral vasospasm. Neurosurgery 1995; 37:78-85.

http://dx.doi.org/10.1227/00006123-199507000-00012

[
Pubmed]   


10.Gebre-Medhin M, Ewald U, Platin L. Elevated serum selenium in diabetic children. Acta Pediatr Scand 1984; 73:109-14.

http://dx.doi.org/10.1111/j.1651-2227.1984.tb09907.x

[
Pubmed]   


11.Toufektsian MC, Boucher F, Pucheu S, Tanguy S, Ribuot C, Sanou D, Tresallet N, de Leiris J. Effect of selenium deficiency on the response of cardiac tissue to ischemia and reperfusion. Toxicology 2000; 148:125-32.

http://dx.doi.org/10.1016/S0300-483X(00)00203-1

[
Pubmed]   


12.Allan C, Lacourciere G, Stadtman T. Responsiveness of selenoproteins to dietary selenium. Ann Rev Nutr 1999; 19:1-16.

http://dx.doi.org/10.1146/annurev.nutr.19.1.1

[
Pubmed]   


13.Liu D, Liu S, Huang Y, Liu Y, Zhang Z, Han L. Effect of selenium on human myocardial glutathione peroxidase gene expression. Chin Med J 2000; 113:771-5.

[
Pubmed]   


14.Oster O, Dexler M, Schenk J, Menertz T, Kasper W, Schuster CJ, Prellwitz W. The serum slelenium concentration of patients with acute myocatdial infarction. Ann Clin Res 1986; 18:36-42

[
Pubmed]   


15.Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, Smieja M, Cambien F, Meyer J, Lackner KJ; AtheroGene Investigators. Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med 2003; 349:1605-13.

http://dx.doi.org/10.1056/NEJMoa030535

[
Pubmed]   


16.Espinola-Klein C, Rupprecht HJ, Bickel C, Schnabel R, Genth-Zotz S, Torzewski M, Lackner K, Munzel T, Blankenberg S; AtheroGene Investigators. Glutathione peroxidase-1 activity, atherosclerotic burden, and cardiovascular prognosis. Am J Cardiol 2007; 99:808-12.

http://dx.doi.org/10.1016/j.amjcard.2006.10.041

[
Pubmed]   


17.Koca HB. In coronary artery patients, lipid and protein oxidation with selenium containing antioxidant levels. Master Thesis; Afyon Kocatepe University, Afyonkarahisar, Turkey, 2007.


18.Savarino L, Granchi D, Ciapetti G, Cenni E, Ravaglia G, Forti P, Maioli F, Mattioli R. Serum concentrations of zinc and selenium in elderly people: results in healthy nonagenarians/centenarians. Exp Gerontol 2001; 36:327-39.

http://dx.doi.org/10.1016/S0531-5565(00)00218-7

[
Pubmed]   


19.Cheng ML, Chen CM, Ho HY, Li JM, Chiu DT. Effect of acute myocardial infarction on erythrocytic glutathione peroxidase 1 activity and plasma vitamin levels. Am J Cardiol. 2009; 103:471-5.

http://dx.doi.org/10.1016/j.amjcard.2008.09.104

[
Pubmed]   


20.Bor MV, Cevik C, Uslu I, Guneral F, Duzgun E. Selenium levels and glutathione peroxidase activities in patients with acute myocardial infarction. Acta Cardiol. 1999; 54:271-6.

[
Pubmed]   


This Article Cited By the following articles

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1
 
How to Cite this Article
Pubmed Style

Meral Gunaldi, Aysen Helvaci, Mehmet Zorlu, Muharrem Kiskac, Nergis Ekmen, Gulay Yilmaz. Alteration in serum levels of selenium and glutathione peroxidase in acute myocardial infarction. Oxid Antioxid Med Sci. 2012; 1(3): 175-178. doi:10.5455/oams.170912.br.003


Web Style

Meral Gunaldi, Aysen Helvaci, Mehmet Zorlu, Muharrem Kiskac, Nergis Ekmen, Gulay Yilmaz. Alteration in serum levels of selenium and glutathione peroxidase in acute myocardial infarction. http://www.ejmoams.com/?mno=24880 [Access: November 16, 2018]. doi:10.5455/oams.170912.br.003


AMA (American Medical Association) Style

Meral Gunaldi, Aysen Helvaci, Mehmet Zorlu, Muharrem Kiskac, Nergis Ekmen, Gulay Yilmaz. Alteration in serum levels of selenium and glutathione peroxidase in acute myocardial infarction. Oxid Antioxid Med Sci. 2012; 1(3): 175-178. doi:10.5455/oams.170912.br.003



Vancouver/ICMJE Style

Meral Gunaldi, Aysen Helvaci, Mehmet Zorlu, Muharrem Kiskac, Nergis Ekmen, Gulay Yilmaz. Alteration in serum levels of selenium and glutathione peroxidase in acute myocardial infarction. Oxid Antioxid Med Sci. (2012), [cited November 16, 2018]; 1(3): 175-178. doi:10.5455/oams.170912.br.003



Harvard Style

Meral Gunaldi, Aysen Helvaci, Mehmet Zorlu, Muharrem Kiskac, Nergis Ekmen, Gulay Yilmaz (2012) Alteration in serum levels of selenium and glutathione peroxidase in acute myocardial infarction. Oxid Antioxid Med Sci, 1 (3), 175-178. doi:10.5455/oams.170912.br.003



Turabian Style

Meral Gunaldi, Aysen Helvaci, Mehmet Zorlu, Muharrem Kiskac, Nergis Ekmen, Gulay Yilmaz. 2012. Alteration in serum levels of selenium and glutathione peroxidase in acute myocardial infarction. Oxidants and Antioxidants in Medical Science, 1 (3), 175-178. doi:10.5455/oams.170912.br.003



Chicago Style

Meral Gunaldi, Aysen Helvaci, Mehmet Zorlu, Muharrem Kiskac, Nergis Ekmen, Gulay Yilmaz. "Alteration in serum levels of selenium and glutathione peroxidase in acute myocardial infarction." Oxidants and Antioxidants in Medical Science 1 (2012), 175-178. doi:10.5455/oams.170912.br.003



MLA (The Modern Language Association) Style

Meral Gunaldi, Aysen Helvaci, Mehmet Zorlu, Muharrem Kiskac, Nergis Ekmen, Gulay Yilmaz. "Alteration in serum levels of selenium and glutathione peroxidase in acute myocardial infarction." Oxidants and Antioxidants in Medical Science 1.3 (2012), 175-178. Print. doi:10.5455/oams.170912.br.003



APA (American Psychological Association) Style

Meral Gunaldi, Aysen Helvaci, Mehmet Zorlu, Muharrem Kiskac, Nergis Ekmen, Gulay Yilmaz (2012) Alteration in serum levels of selenium and glutathione peroxidase in acute myocardial infarction. Oxidants and Antioxidants in Medical Science, 1 (3), 175-178. doi:10.5455/oams.170912.br.003





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