ISSN 2146-8389
 

Original Research (Original Article) Open Access


Early atherosclerosis development in female apolipoprotein E-deficient mice is associated with an increased vascular oxidative stress

Livan Delgado-Roche, Yanet Hernandez, Ivonilce Venturi, Irina Wilkins, Dalia Alvarez.

Cited by (1)

Abstract
Objective: The mechanisms of atherosclerosis development in the apolipoprotein E-deficient (apoE−/−) mice have been clearly described. In this genetically modified strain, oxidative stress contributes with atherosclerotic lesion progression. However, there are controversial criteria on the vulnerability of female apoE−/− mouse to oxidative stress and atherosclerosis during the fertile period. Thus, the aim of the present work was to examine the implication of vascular oxidative stress during early atherosclerosis development in young apoE−/− female mice.
Methods: AQ1 Please provide a brief methodology
Results: Hematoxylin/eosin staining demonstrated the presence of early atherosclerotic lesions in the apoE−/− mice, which progressed with age. Dihydroethidium staining of aortic sections revealed a significant increase of superoxide anion generation in apoE−/− compared with the wild type mice. The increment of this reactive oxygen species was associated, at least, with the overexpression of Nox2 mRNA levels. In addition, the 8-week-old apoE−/− mice had a significant increment of lipid and protein damage, as well as a disruption of superoxide dismutase and catalase activity, together with a deprivation of reduced glutathione and an impairment of nitric oxide availability.
Conclusion: The present study shows that early atherosclerotic lesion formation in young apoE−/− female mice is associated with an increment of Nox2-mediated reactive oxygen species generation with the subsequent redox disruption, suggesting a key role of oxidative stress during atherogenesis in fertile apoE−/− female mice.

Key words: Atherosclerosis, female apoE-deficient mice, Nox2


 
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How to Cite this Article
Pubmed Style

Delgado-Roche L, Hernandez Y, Venturi I, Wilkins I, Alvarez D. Early atherosclerosis development in female apolipoprotein E-deficient mice is associated with an increased vascular oxidative stress. Oxid Antioxid Med Sci. 2016; 5(1): 15-20. doi:10.5455/oams.030316.or.093


Web Style

Delgado-Roche L, Hernandez Y, Venturi I, Wilkins I, Alvarez D. Early atherosclerosis development in female apolipoprotein E-deficient mice is associated with an increased vascular oxidative stress. http://www.ejmoams.com/?mno=215671 [Access: February 20, 2018]. doi:10.5455/oams.030316.or.093


AMA (American Medical Association) Style

Delgado-Roche L, Hernandez Y, Venturi I, Wilkins I, Alvarez D. Early atherosclerosis development in female apolipoprotein E-deficient mice is associated with an increased vascular oxidative stress. Oxid Antioxid Med Sci. 2016; 5(1): 15-20. doi:10.5455/oams.030316.or.093



Vancouver/ICMJE Style

Delgado-Roche L, Hernandez Y, Venturi I, Wilkins I, Alvarez D. Early atherosclerosis development in female apolipoprotein E-deficient mice is associated with an increased vascular oxidative stress. Oxid Antioxid Med Sci. (2016), [cited February 20, 2018]; 5(1): 15-20. doi:10.5455/oams.030316.or.093



Harvard Style

Delgado-Roche, L., Hernandez, Y., Venturi, I., Wilkins, I. & Alvarez, D. (2016) Early atherosclerosis development in female apolipoprotein E-deficient mice is associated with an increased vascular oxidative stress. Oxid Antioxid Med Sci, 5 (1), 15-20. doi:10.5455/oams.030316.or.093



Turabian Style

Delgado-Roche, Livan, Yanet Hernandez, Ivonilce Venturi, Irina Wilkins, and Dalia Alvarez. 2016. Early atherosclerosis development in female apolipoprotein E-deficient mice is associated with an increased vascular oxidative stress. Oxidants and Antioxidants in Medical Science, 5 (1), 15-20. doi:10.5455/oams.030316.or.093



Chicago Style

Delgado-Roche, Livan, Yanet Hernandez, Ivonilce Venturi, Irina Wilkins, and Dalia Alvarez. "Early atherosclerosis development in female apolipoprotein E-deficient mice is associated with an increased vascular oxidative stress." Oxidants and Antioxidants in Medical Science 5 (2016), 15-20. doi:10.5455/oams.030316.or.093



MLA (The Modern Language Association) Style

Delgado-Roche, Livan, Yanet Hernandez, Ivonilce Venturi, Irina Wilkins, and Dalia Alvarez. "Early atherosclerosis development in female apolipoprotein E-deficient mice is associated with an increased vascular oxidative stress." Oxidants and Antioxidants in Medical Science 5.1 (2016), 15-20. Print. doi:10.5455/oams.030316.or.093



APA (American Psychological Association) Style

Delgado-Roche, L., Hernandez, Y., Venturi, I., Wilkins, I. & Alvarez, D. (2016) Early atherosclerosis development in female apolipoprotein E-deficient mice is associated with an increased vascular oxidative stress. Oxidants and Antioxidants in Medical Science, 5 (1), 15-20. doi:10.5455/oams.030316.or.093





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