ISSN 2146-8389
 

Original Research (Original Article) 


Redox indexes and progression markers in HIV-infected patients treated with three different HAART combinations

Rosario G. Hernandez, Ivon G. Blanco, Daniel P. Correa, Dayme H. Requejo, Yusimit B. Alfonso, Lizette G. del Valle, Olga S. L. Fernandez, Jorge P. Avila.

Abstract
Objective: Highly active antiretroviral therapy (HAART) is the choice to treat cases with an established HIV-infection and to prevent establishment of infection after exposure. Oxidative stress has been associated to HIV infection and, depending of therapy combination, effectiveness and adherence, to HAART. This study assessed the effect of three different HAART combinations, i.e. zidovudine/lamivudine/nevirapine (I), zidovudine/lamivudine/indinavir (II) and stavudine/lamivudine/nevirapine (III), on redox indexes and progression markers of disease on blood.
Methods: We recruited 200 individuals of which 160 were HIV+ (40 never treated and 120 were taking different HAART combinations for at least six months), and the other 40 were supposedly healthy voluntaries (SHV). Peroxidation potential, glutathione, malondialdehyde, hydroperoxides, superoxide dismutase (SOD), catalase, advanced oxidation protein products (AOPP), viral load and CD4 lymphocytes T subsets were measured at baseline for all individuals and after 6 months.
Results: The comparison between SHV and HIV treated or non-treated patients groups showed significant differences in almost all redox indexes with different molecular significance. Statistically modified values were found in almost all redox indexes at 6 months compared to the baseline except in SOD activity and peroxidation potential for combination I and III combinations and AOPP and SOD activity for combination II. Insignificant differences were found between HIV+ patients groups with respect to CD4 T lymphocyte subsets. The 78% of patients receiving treatment showed a viral load reduction. The multivariate statistical model clearly separated treated groups according progression indexes and redox profile.
Conclusion: Therapeutic effectiveness confirmation and its benefits in HIV-infected patients combined with additional oxidative stress impact promoted integral view approach to follow up infection.

Key words: Antiretroviral therapy; HIV; Oxidative stress; Redox indexes


 
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How to Cite this Article
Pubmed Style

Hernandez RG, Blanco IG, Correa DP, Requejo DH, Alfonso YB, Valle LGd, Fernandez OSL, Avila JP. Redox indexes and progression markers in HIV-infected patients treated with three different HAART combinations. Oxid Antioxid Med Sci. 2014; 3(3): 201-209. doi:10.5455/oams.170914.or.074


Web Style

Hernandez RG, Blanco IG, Correa DP, Requejo DH, Alfonso YB, Valle LGd, Fernandez OSL, Avila JP. Redox indexes and progression markers in HIV-infected patients treated with three different HAART combinations. http://www.ejmoams.com/?mno=163587 [Access: August 20, 2018]. doi:10.5455/oams.170914.or.074


AMA (American Medical Association) Style

Hernandez RG, Blanco IG, Correa DP, Requejo DH, Alfonso YB, Valle LGd, Fernandez OSL, Avila JP. Redox indexes and progression markers in HIV-infected patients treated with three different HAART combinations. Oxid Antioxid Med Sci. 2014; 3(3): 201-209. doi:10.5455/oams.170914.or.074



Vancouver/ICMJE Style

Hernandez RG, Blanco IG, Correa DP, Requejo DH, Alfonso YB, Valle LGd, Fernandez OSL, Avila JP. Redox indexes and progression markers in HIV-infected patients treated with three different HAART combinations. Oxid Antioxid Med Sci. (2014), [cited August 20, 2018]; 3(3): 201-209. doi:10.5455/oams.170914.or.074



Harvard Style

Hernandez, R. G., Blanco, I. G., Correa, D. P., Requejo, D. H., Alfonso, Y. B., Valle, L. G. d., Fernandez, O. S. L. & Avila, J. P. (2014) Redox indexes and progression markers in HIV-infected patients treated with three different HAART combinations. Oxid Antioxid Med Sci, 3 (3), 201-209. doi:10.5455/oams.170914.or.074



Turabian Style

Hernandez, Rosario G., Ivon G. Blanco, Daniel P. Correa, Dayme H. Requejo, Yusimit B. Alfonso, Lizette G. del Valle, Olga S. L. Fernandez, and Jorge P. Avila. 2014. Redox indexes and progression markers in HIV-infected patients treated with three different HAART combinations. Oxidants and Antioxidants in Medical Science, 3 (3), 201-209. doi:10.5455/oams.170914.or.074



Chicago Style

Hernandez, Rosario G., Ivon G. Blanco, Daniel P. Correa, Dayme H. Requejo, Yusimit B. Alfonso, Lizette G. del Valle, Olga S. L. Fernandez, and Jorge P. Avila. "Redox indexes and progression markers in HIV-infected patients treated with three different HAART combinations." Oxidants and Antioxidants in Medical Science 3 (2014), 201-209. doi:10.5455/oams.170914.or.074



MLA (The Modern Language Association) Style

Hernandez, Rosario G., Ivon G. Blanco, Daniel P. Correa, Dayme H. Requejo, Yusimit B. Alfonso, Lizette G. del Valle, Olga S. L. Fernandez, and Jorge P. Avila. "Redox indexes and progression markers in HIV-infected patients treated with three different HAART combinations." Oxidants and Antioxidants in Medical Science 3.3 (2014), 201-209. Print. doi:10.5455/oams.170914.or.074



APA (American Psychological Association) Style

Hernandez, R. G., Blanco, I. G., Correa, D. P., Requejo, D. H., Alfonso, Y. B., Valle, L. G. d., Fernandez, O. S. L. & Avila, J. P. (2014) Redox indexes and progression markers in HIV-infected patients treated with three different HAART combinations. Oxidants and Antioxidants in Medical Science, 3 (3), 201-209. doi:10.5455/oams.170914.or.074





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    Ochuko L. Erukainure, Oluwatoyin V. Oke, Folashade O. Owolabi, Funmi O. Kayode, Emmanuel E. Umanhonlen, Muhammad Aliyu
    Oxid Antioxid Med Sci. 2012; 1(2): 127-132
    » Abstract & References » doi: 10.5455/oams.080712.or.009
    Cited : 13 times [Click to see citing articles]

  • Anticancer and free radical scavenging potency of Catharanthus roseus, Dendrophthoe petandra, Piper betle and Curcuma mangga extracts in breast cancer cell lines
    Wahyu Widowati, Tjandrawati Mozef, Chandra Risdian, Yellianty Yellianty
    Oxid Antioxid Med Sci. 2013; 2(2): 137-142
    » Abstract & References » doi: 10.5455/oams.100413.or.038
    Cited : 11 times [Click to see citing articles]

  • Role of free radicals and antioxidants in gynecological cancers: current status and future prospects
    Lokanatha Valluru, Subramanyam Dasari, Rajendra Wudayagiri
    Oxid Antioxid Med Sci. 2014; 3(1): 15-26
    » Abstract & References » doi: 10.5455/oams.201113.rv.011
    Cited : 10 times [Click to see citing articles]

  • Silymarin and naringenin protects nicotine induced oxidative stress in young rats
    Anshu Jain, Nidhi Dwivedi, Rakesh Bhargava, Swaran J.S. Flora
    Oxid Antioxid Med Sci. 2012; 1(1): 41-49
    » Abstract & References » doi: 10.5455/oams.130412.or.004
    Cited : 9 times [Click to see citing articles]

  • Phytochemical and in vitro antioxidant properties of the methanolic extract of fruits of Blighia sapida, Vitellaria paradoxa and Vitex doniana
    Rabiat U. Hamzah, Evans C. Egwim, Adamu Y. Kabiru, Mary B. Muazu
    Oxid Antioxid Med Sci. 2013; 2(3): 217-223
    » Abstract & References » doi: 10.5455/oams.090513.or.043
    Cited : 9 times [Click to see citing articles]

  • Palm vitamin E reduces oxidative stress, and physical and morphological alterations of erythrocyte membranes in streptozotocin-induced diabetic rats
    Fatmah Ali Matough, Siti Balkis Budin, Zariyantey Abdul Hamid, Santhana Raj Louis, Nasar Alwahaibi, Jamaludin Mohamed
    Oxid Antioxid Med Sci. 2012; 1(1): 59-68
    » Abstract & References » doi: 10.5455/oams.300412.or.006
    Cited : 8 times [Click to see citing articles]

  • Peroxidative index as novel marker of hydrogen peroxide involvement in lipid peroxidation from coal dust exposure
    Nia Kania, Bambang Setiawan, Edi Widjajanto, Nurdiana Nurdiana, M. Aris Widodo, H.M.S. Chandra Kusuma
    Oxid Antioxid Med Sci. 2012; 1(3): 209-215
    » Abstract & References » doi: 10.5455/oams.031012.or.020
    Cited : 8 times [Click to see citing articles]

  • Cytotoxic and proapoptotic activities of gallic acid to human oral cancer HSC-2 cells
    Alyssa G. Schuck, Jeffrey H. Weisburg, Hannah Esan, Esther F. Robin, Ayelet R. Bersson, Jordana R. Weitschner, Tova Lahasky, Harriet L. Zuckerbraun, Harvey Babich
    Oxid Antioxid Med Sci. 2013; 2(4): 265-274
    » Abstract & References » doi: 10.5455/oams.220713.or.051
    Cited : 7 times [Click to see citing articles]

  • Heparin or EDTA; anticoagulant of choice in free radical estimation?
    Kuldeep Mohanty, Swetasmita Mishra, Jhumur Pani, Tarannum Hasan, Abhishek Purohit, Subhadra Sharma, Rima Dada
    Oxid Antioxid Med Sci. 2012; 1(1): 21-24
    » Abstract & References » doi: 10.5455/oams.130512.br.001
    Cited : 6 times [Click to see citing articles]

  • Antimicrobial and antioxidant properties of marine actinomycetes Streptomyces sp VITSTK7
    Mohankumar Thenmozhi, Krishnan Kannabiran
    Oxid Antioxid Med Sci. 2012; 1(1): 51-57
    » Abstract & References » doi: 10.5455/oams.270412.or.005
    Cited : 6 times [Click to see citing articles]