ISSN 2146-8389
 

Original Research (Original Article) Open Access


Cytotoxic and antioxidant activities of catechins in inhibiting the malignancy of breast cancer

Endang Evacuasiany, Hana Ratnawati, Laella K. Liana, Wahyu Widowati, Maesaroh Maesaroh, Tjandrawati Mozef, Chandra Risdian.

Cited by (1)

Abstract
Objective: Breast cancer is a malignant disease of women most often found after cervical cancer in Indonesia. Increased levels of free radicals can cause DNA damage, which could lead to malignancy; this can play role in breast cancer etiopathogenesis. The present research was conducted to determine the activity of catechins as antioxidants and their potential efficacy in inhibiting breast cancer malignancy.
Methods: The research was done by examining the antioxidant and free radical scavenging activity including 1,1-diphenyl-2-picryl-hydrazyl (DPPH), the value of superoxide dismutase (SOD), and assays in breast cancer cell lines (T47D, MCF7). The cytotoxic potency was determined by the MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay.
Results: The highest DPPH scavenging activity is presented by (-)-epigallocatechin (EGC) and the lowest by gallo catechins (GC). The highest SOD value were reached with EGC at 500 g/ml, followed by (-)-epicatechin gallate (ECG) at 125 g/ml, and GC at 31.25 g/ml concentrations. The highest cytotoxic activity in T47D cell line for 24 and 48 h incubation was exhibited by (-)-gallocatechin gallate (GCG). The greatest cytotoxic activity in MCF7 cell line for 24 h was presented by (-)-epigallocatechin gallate (EGCG), and for 48 h incubation by (+)-catechin (C).
Conclusion: Catechins have high antioxidant activities proven by both DPPH scavenging and SOD activities. They possess higher anticancer action on T47D than on MCF7 cell line.

Key words: Breast cancer; Catechins; Cytotoxicity; Free radicals


 
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This Article Cited By the following articles

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Nat Prod Sci 2016; 22(2): 87.

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How to Cite this Article
Pubmed Style

Evacuasiany E, Ratnawati H, Liana LK, Widowati W, Maesaroh M, Mozef T, Risdian C. Cytotoxic and antioxidant activities of catechins in inhibiting the malignancy of breast cancer. Oxid Antioxid Med Sci. 2014; 3(2): 141-146. doi:10.5455/oams.240614.or.066


Web Style

Evacuasiany E, Ratnawati H, Liana LK, Widowati W, Maesaroh M, Mozef T, Risdian C. Cytotoxic and antioxidant activities of catechins in inhibiting the malignancy of breast cancer. http://www.ejmoams.com/?mno=152753 [Access: February 20, 2018]. doi:10.5455/oams.240614.or.066


AMA (American Medical Association) Style

Evacuasiany E, Ratnawati H, Liana LK, Widowati W, Maesaroh M, Mozef T, Risdian C. Cytotoxic and antioxidant activities of catechins in inhibiting the malignancy of breast cancer. Oxid Antioxid Med Sci. 2014; 3(2): 141-146. doi:10.5455/oams.240614.or.066



Vancouver/ICMJE Style

Evacuasiany E, Ratnawati H, Liana LK, Widowati W, Maesaroh M, Mozef T, Risdian C. Cytotoxic and antioxidant activities of catechins in inhibiting the malignancy of breast cancer. Oxid Antioxid Med Sci. (2014), [cited February 20, 2018]; 3(2): 141-146. doi:10.5455/oams.240614.or.066



Harvard Style

Evacuasiany, E., Ratnawati, H., Liana, L. K., Widowati, W., Maesaroh, M., Mozef, T. & Risdian, C. (2014) Cytotoxic and antioxidant activities of catechins in inhibiting the malignancy of breast cancer. Oxid Antioxid Med Sci, 3 (2), 141-146. doi:10.5455/oams.240614.or.066



Turabian Style

Evacuasiany, Endang, Hana Ratnawati, Laella K. Liana, Wahyu Widowati, Maesaroh Maesaroh, Tjandrawati Mozef, and Chandra Risdian. 2014. Cytotoxic and antioxidant activities of catechins in inhibiting the malignancy of breast cancer. Oxidants and Antioxidants in Medical Science, 3 (2), 141-146. doi:10.5455/oams.240614.or.066



Chicago Style

Evacuasiany, Endang, Hana Ratnawati, Laella K. Liana, Wahyu Widowati, Maesaroh Maesaroh, Tjandrawati Mozef, and Chandra Risdian. "Cytotoxic and antioxidant activities of catechins in inhibiting the malignancy of breast cancer." Oxidants and Antioxidants in Medical Science 3 (2014), 141-146. doi:10.5455/oams.240614.or.066



MLA (The Modern Language Association) Style

Evacuasiany, Endang, Hana Ratnawati, Laella K. Liana, Wahyu Widowati, Maesaroh Maesaroh, Tjandrawati Mozef, and Chandra Risdian. "Cytotoxic and antioxidant activities of catechins in inhibiting the malignancy of breast cancer." Oxidants and Antioxidants in Medical Science 3.2 (2014), 141-146. Print. doi:10.5455/oams.240614.or.066



APA (American Psychological Association) Style

Evacuasiany, E., Ratnawati, H., Liana, L. K., Widowati, W., Maesaroh, M., Mozef, T. & Risdian, C. (2014) Cytotoxic and antioxidant activities of catechins in inhibiting the malignancy of breast cancer. Oxidants and Antioxidants in Medical Science, 3 (2), 141-146. doi:10.5455/oams.240614.or.066





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